Publications by authors named "Weili Zhao"

Background: The shape and size of the meniscus are closely related to the stability of the knee joint and the anterior cruciate ligament (ACL) injury. Studies have confirmed the correlation between meniscal morphology and isolated ACL injury.

Purpose: To investigate meniscal parameters, including morphological changes, in participants with isolated ACL injury.

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The complement system's distinguishing feature is its cell-specific surface ligands. However, the limited scalability and complexity of incorporating surface-customizable ligands into membrane-bound cell-like microassemblages have hindered their widespread adoption in synthetic biology and bioengineering. Here, we present a method for the batch construction of polysaccharide-based microcapsules (polysaccharidosomes, P-somes) with intrinsic functional host membranes capable of docking guest ligands via facile host-guest interactions.

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Background: Risk stratification of spinal tumors is a major unmet clinical need for personalized therapy.

Purpose: To explore the feasibility of pretreatment whole-lesion apparent diffusion coefficient (ADC) histogram in predicting local recurrence of aggressive spinal tumors.

Methods: 119 aggressive spinal tumor patients (median age, 40; range, 13-74  years) confirmed by pathological findings with a mean follow-up of 36 months were enrolled and divided into the recurrence and non-recurrence group.

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Purpose: To explore the clinical features, diagnosis, treatment, and prognosis of anthrax meningoencephalitis.

Methods: The clinical data of two cases of anthrax meningoencephalitis were summarized and the relevant literature was reviewed.

Results: Both patients, who were farmers, had cutaneous lesions prior to the onset of meningoencephalitis.

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Background: HMPL-306 has equally high inhibitory activity against mutated isocitrate dehydrogenases 1 and 2 (mIDH1/2).

Methods: This first-in-human, phase 1 dose-escalation/dose-expansion study (this study was registered at ClinicalTrials.gov: NCT04272957) enrolled patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) harboring mIDH1 and/or mIDH2.

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Immunomodulatory agent lenalidomide is effective in treating follicular lymphoma (FL). We conducted the first trial of immunotherapy rituximab plus lenalidomide in newly diagnosed FL in China (NCT03715309). One-hundred and fifteen patients were enrolled and treated with rituximab 375 mg/m intravenously on day 0 and lenalidomide 25 mg orally on day 1-10 for 6 cycles of induction treatment, as well as lenalidomide for 6 cycles and rituximab for 8 cycles of maintenance treatment.

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Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-κB signaling and oxidative stress play vital roles in both muscle atrophy and fat loss in CAC.

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Background: Disease progression within 24 months (POD24) significantly impacts overall survival (OS) in patients with follicular lymphoma (FL). This study aimed to develop a robust predictive model, FLIPI-C, using a machine learning approach to identify FL patients at high risk of POD24.

Methods: A cohort of 1,938 FL patients (FL1-3a) from seventeen centers nationwide in China was randomly divided into training and internal validation sets (2:1 ratio).

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Newly diagnosed follicular lymphoma (FL) patients usually received first-line rituximab-based immunochemotherapy (R-chemo). Recently, rituximab plus lenalidomide (R2) emerged as an alternative chemo-free immunotherapy. We performed a comparative analysis of positron emission tomography/computed tomography (PET/CT) in FL undergoing R-chemo or R2.

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Article Synopsis
  • Alcoholic liver disease (ALD) is increasingly prevalent due to a rise in global drinkers, posing serious health risks, including inflammation linked to high levels of reactive oxygen species like HClO.
  • Researchers developed a sensitive NIR fluorescent probe (BDP-ENE-Fur-HClO) that can detect HClO in real-time, allowing for the imaging of ALD in living cells without interference from other compounds.
  • The probe has demonstrated effectiveness in monitoring liver injury in animal models of ALD and assessing the impact of hepatoprotective treatments, highlighting its potential as a diagnostic tool for ALD.
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Background: A deep learning (DL) model that can automatically detect and classify cervical canal and neural foraminal stenosis using cervical spine magnetic resonance imaging (MRI) can improve diagnostic accuracy and efficiency.

Methods: A method comprising region-of-interest (ROI) detection and cascade prediction was formulated for diagnosing cervical spinal stenosis based on a DL model. First, three part-specific convolutional neural networks were employed to detect the ROIs in different parts of the cervical MR images.

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A series of integrin αβ targeting BODIPY-RGD conjugate were designed and synthesized. Their in vitro and in vivo fluorescence imaging behaviors were investigated. The small molecule compound was designed as an optical imaging near-infrared fluorescent dye which was combined RGD peptide with the meso-amide BODIPYs using succinic moiety as a spacer.

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  • This study evaluated how well radiation therapy combined with chemotherapy works for patients with early-stage extranodal natural killer/T-cell lymphoma, focusing on treatment outcomes, side effects, and prognostic factors.
  • A total of 118 patients were analyzed, showing high overall (93.2%) and complete response rates (82.2%), with median 5-year overall survival at 73.9% and progression-free survival at 68.4%.
  • Factors influencing survival included treatment type and location of the disease, where non-anthracycline-based regimens improved survival rates compared to anthracycline-based ones, and primary lesions in Waldeyer's ring correlated with poorer outcomes.
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  • Vitamin E is an essential micronutrient that may reduce cardiovascular risk in diabetes patients with the Hp 2-2 genotype, though the exact mechanism is not well understood.
  • A systematic review was conducted, examining 163 publications and ultimately including five studies with 463 participants, focusing on the effects of vitamin E on high-density lipoprotein (HDL) levels and function.
  • Results showed that while vitamin E did not significantly change HDL levels across all Hp genotypes, it appeared to enhance HDL function, specifically improving cholesterol efflux in Hp 2-2 diabetes patients, indicating a potential pharmacogenetic interaction.
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  • A phase 3 trial compared the effectiveness and safety of zuberitamab combined with CHOP chemotherapy (Hi-CHOP) against rituximab combined with CHOP (R-CHOP) in patients with untreated CD20-positive diffuse large B-cell lymphoma (DLBCL).
  • The trial involved 487 patients, with a primary focus on the objective response rate (ORR) after six treatment cycles, finding that Hi-CHOP achieved a similar ORR to R-CHOP while demonstrating a significantly higher complete response (CR) rate in some analyses.
  • Long-term follow-up indicated that Hi-CHOP patients experienced improved duration of response (DOR), progression-free survival (PFS), and overall survival
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  • The BAD-study was a comprehensive analysis of branch atheromatous disease (BAD)-related strokes in 476 patients across 20 hospitals in China, focusing on demographic, clinical, and therapeutic aspects.
  • The study found that the majority of participants were middle-aged and male, with a higher occurrence of strokes linked to the lenticulostriate artery; 86.5% of patients had good outcomes by 90 days, despite 14.7% experiencing early neurological deterioration.
  • Key predictors of poor outcomes included higher stroke severity at admission and early deterioration, while extracranial artery stenosis was associated with better outcomes.
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Establishing predictive models for the pathological response and lymph node metastasis in locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT) based on MRI radiomic features derived from the tumor and mesorectal compartment (MC). This study included 209 patients with LARC who underwent rectal MRI both before and after nCRT. The patients were divided into a training set (n = 146) and a test set (n = 63).

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  • CAR-T cell therapy helps patients with a type of cancer called large B-cell lymphoma (LBCL) who haven't gotten better with other treatments.
  • A study looked at 90 patients and found that smaller tumors (less than 6 cm) responded better to this therapy, with more of them getting better after three months.
  • New tests and models were created to predict how well patients might respond to treatment, which could help doctors decide the best way to help each patient.
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Background: Peripheral T-cell lymphoma (PTCL) is a heterogeneous disease with dismal outcomes. We conducted an open-label, phase 2 nonrandomised, externally controlled study to evaluate the efficacy and safety of targeted agents plus CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) (CHOPX) for PTCL in the front-line setting.

Methods: Eligible patients were ≥18 years of age and newly diagnosed PTCL.

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In this work, various novel pyridinyl- and pyridinium-modified Aza-BODIPY PSs were designed and constructed based on monoiodo Aza-BODIPY PSs ( and ) in an attempt to construct "structure-inherent organelles-targeted" PSs to endow potential organelle-targeting ability. Pyridinyl PSs displayed potent photodynamic efficacy, and monorigidified PSs were very effective. The monorigidified PS with -pyridinyl moiety displayed the most potent photoactivity and negligible dark toxicity with a favorable dark/phototoxicity ratio (>4800).

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  • The IELSG37 trial investigated whether patients with primary mediastinal B-cell lymphoma (PMBCL) who have a complete metabolic response (CMR) after treatment can safely skip consolidation radiotherapy.
  • It was a randomized noninferiority study involving 545 patients, focusing on progression-free survival (PFS) over 30 months, with results showing high PFS rates of 96.2% for observation and 98.5% for radiotherapy.
  • The study concluded that avoiding irradiation does not negatively impact survival, highlighting positive outcomes for patients with CMR.
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Accurate fluorescence imaging of nanocarriers in vivo remains a challenge owing to interference derived mainly from biological tissues and free probes. To address both issues, the current study explored fluorophores in the near-infrared (NIR)-II window with aggregation-caused quenching (ACQ) properties to improve imaging accuracy. Candidate fluorophores with NIR-II emission, ACQ984 (λ = 984 nm) and IR-1060 (λ = 1060 nm), from the aza-BODIPY and cyanine families, respectively, were compared with the commercial fluorophore ICG with NIR-II tail emission and the NIR-I fluorophore P2 from the aza-BODIPY family.

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  • Scientists found that a gene called histone methyltransferase is often changed in a type of cancer called diffuse large B-cell lymphoma (DLBCL).
  • Out of 761 DLBCL patients studied, about 19% had these gene changes, which were linked to more severe cancer stages and lower chances of survival.
  • In experiments with mouse models, researchers discovered that these gene changes led to faster tumor growth by affecting how certain immune cells traveled to the tumor.
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