Total burden of cerebral small vessel disease predict subjective cognitive decline in patients with Parkinson's disease.

Introduction: This study investigates the correlation between the total burden of Cerebral Small Vessel Disease (CSVD) and Subjective Cognitive Decline (SCD) in patients with Parkinson's disease (PD).

Methods: A cross-sectional design was employed, involving 422 patients with PD. Demographic and clinical data were collected.

Differential Performance of Xanthophylls in Combination with Phenol Classes against HO-Induced Oxidative Stress: An In Vitro Analysis Using Retinal Pigment Epithelial Cells.

Scope: Xanthophylls, vital for ocular defense against blue light and reactive oxygen species, are prone to oxidative degradation; however, they may be regenerated antioxidant-rich plant phenols. Despite certain in vitro evidence, clinical studies show inconsistent findings and this may be due to varying phenolic reduction potentials. Therefore, the current study aims to investigate the ocular protective effect of various plant phenols combined with xanthophyll.

Effect of Antioxidant Supplementation on Macular Pigment Optical Density and Visual Functions: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Antioxidants are bioactive molecules that function to scavenge free radicals and balance oxidative stress. Although all antioxidants can act as reactive oxygen species scavengers, their efficacy on eye health may vary. Moreover, the comparative effectiveness and potential additive effect between groups of antioxidants, hitherto, have not been systematically studied.

Synthesis and evaluation of nitrogen-containing derivatives of 3,11-dioxo-olean-12-en-30-oic acid against HIV-1 protease.

Thirteen nitrogen-containing derivatives of 3,11-dioxo-olean-12-en-30-oic acid were synthesised by introducing various amino acids and nitrogen-containing heterocyclic groups at the 30-carboxyl group, starting from 18-glycyrrhetinic acid. Among the 13 derivatives, 10 exhibited inhibitory activity against HIV-1 PR, with IC values ranging from 0.19 to 0.

Integration of comparative transcriptomics and WGCNA characterizes the regulation of anthocyanin biosynthesis in mung bean ( L.).

Mung bean is a dual-use crop widely cultivated in Southeast Asia as a food and medicine resource. The development of new functional mung bean varieties demands identifying new genes regulating anthocyanidin synthesis and investigating their molecular mechanism. In this study, we used high-throughput sequencing technology to generate transcriptome sequence of leaves, petioles, and hypocotyls for investigating the anthocyanins accumulation in common mung bean variety as well as anthocyanidin rich mung bean variety, and to elucidate their molecular mechanisms.

Impacts of regular consumption of grapes on macular pigment accumulation in Singapore older adults: a randomized controlled trial.

: Oxidative stress is a key risk factor for visual impairment and consuming dietary antioxidant-rich foods may help in managing visual impairments. However, a limited number of studies have investigated the effect of dietary antioxidant-rich food including grapes on eye health in older adults. : To assess the effects on macular pigment accumulation of regular consumption of grapes in Singapore older adults.

Constructing an emergency preparedness evaluation index system for public use during major emerging infectious disease outbreaks: a Delphi study.

Background: The major emerging infectious diseases (MEIDs) have occurred frequently and become increasingly serious in the world. Sufficient personal emergency preparedness is critical for the general people in efficiently responding to and recovering from MEIDs. Nevertheless, few specific indicators are available for assessing the individual emergency preparedness of the general public during these periods.

Thermal Percolation in Well-Defined Nanocomposite Thin Films.

Thermal percolation in polymer nanocomposites─the rapid increase in thermal transport due to the formation of networks among fillers─is the subject of great interest in thermal management ranging from general utility in multifunctional nanocomposites to high-conductivity applications such as thermal interface materials. However, It remains a challenging subject encompassing both experimental and modeling hurdles. Successful reports of thermal percolation are exclusively found in high-aspect-ratio, conductive fillers such as graphene, albeit at filler loadings significantly higher than the electrical percolation threshold.

Promotes the Development of Glioma by Ubiquitination and Degradation of .

Objective: To investigate the effect of on glioma cells and further explore its underlying molecular mechanisms.

Methods: Mouse xenograft model was used in this study. The mRNA expression of was detected by qRT-PCR.

From biological enzyme to single atomic Fe-N-C electrocatalyst for efficient oxygen reduction.

Inspired by metabolic processes in biological systems, animal blood as a biowaste rich in biological enzymes with molecular Fe-N centers was successfully explored to produce an efficient electrocatalyst with single atomic Fe-N-C active sites for oxygen reduction reaction.

Granular cell basal cell carcinoma: A case report.

Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC. Our review of the literature revealed only 17 previously identified cases. We report the case of a 47-year-old man who presented with an ulceration on his right upper lip which was subsequently removed.

Well-Defined Metal-O in Metal-Catecholates as a Novel Active Site for Oxygen Electroreduction.

Metal-nitrogen coordination sites, M-N (M = Fe, Co, Ni, etc.), have shown great potential to replace platinum group materials as electrocatalysts for oxygen reduction reaction (ORR). However, the real active site in M-N is still vague to date due to their complicated structure and composition.

Functionalized bacterial cellulose derivatives and nanocomposites.

Bacterial cellulose (BC) is a fascinating and renewable natural nanomaterial characterized by favorable properties such as remarkable mechanical properties, porosity, water absorbency, moldability, biodegradability and excellent biological affinity. Intensive research and exploration in the past few decades on BC nanomaterials mainly focused on their biosynthetic process to achieve the low-cost preparation and application in medical, food, advanced acoustic diaphragms, and other fields. These investigations have led to the emergence of more diverse potential applications exploiting the functionality of BC nanomaterials.

Glycated hemoglobin (HbA1c) affinity biosensors with ring-shaped interdigital electrodes on impedance measurement.

Glycated hemoglobin (HbA1c) is one of the most important diagnostic assays for the long-term mark of glycaemic control in diabetes. This study presents an affinity biosensor for HbA1c detection which is label-free based on the impedance measurement, and it features low cost, low sample volume, and requires no additional reagent in experiments. The ring-shaped interdigital electrodes (RSIDEs) are designed to promote the distribution uniformity and immobilization efficiency of HbA1c, and are further employed to characterize the impedance change and identify various concentrations of HbA1c.

Polyol mediated synthesis of ZnO nanoparticles templated by bacterial cellulose.

Zinc oxide nanoparticles have been successfully synthesized through a facile polyol method using bacterial cellulose (BC) as a template. BC membrane was used as a host matrix to introduce quantitatively Zn(2+) ions and then as nanoreactors to fabricate ZnO nanoparticles by hydrolysis of zinc acetate in a polyol medium. The influence of the concentration of zinc acetate and hydrolytic time on the morphologies and size of ZnO nanoparticles were investigated.

Removal of the sesquiterpene β-caryophyllene from air via biofiltration: performance assessment and microbial community structure.

Experiments were conducted in a laboratory-scale biofilter to assess the ability of a fixed-film biological process to treat an air stream containing β-caryophyllene, a sesquiterpene emitted by a variety of conifer trees as well as industrial wood processing operations. Treatment performance was evaluated under a variety of pollutant loading conditions and nutrient supply rates over an operational period lasting more than 240 days. At empty bed contact times (EBCTs) as low as 10 s and daily average pollutant loading rate as high as 24.

Efficient white polymer light-emitting diodes employing a silver nanowire-polymer composite electrode.

White polymer phosphorescent light-emitting diodes have been fabricated employing silver nanowire (AgNW)-polymer composite substrates. Solution processing is used to form all the layers in the devices, except for the cathode, for potentially low fabrication cost. The current efficiency in the front viewing direction is 20.

Intrinsically stretchable transparent electrodes based on silver-nanowire-crosslinked-polyacrylate composites.

Stretchable transparent composites have been synthesized consisting of a silver nanowire (AgNW) network embedded in the surface layer of a crosslinked poly(acrylate) matrix. The interpenetrating networks of AgNWs and the crosslinked polymer matrix lead to high surface conductivity, high transparency, and rubbery elasticity. The presence of carboxylic acid groups on the polymer chains enhances the bonding between AgNWs and the polymer matrix, and further increases the stretchability of the composites.

Compliant silver nanowire-polymer composite electrodes for bistable large strain actuation.

A new compliant electrode-based on silver nanowire-polymer composite has been developed. The composite electrode has low sheet resistance (as low as 10 Ω/sq), remains conductive (10(2) -10(3) Ω/sq) at strains as high as 140%, and can support Joule heating. The combination of the composite and a bistable electroactive polymer produces electrically-induced, large-strain actuation and relaxation, reversibly without the need of mechanical programming.

Efficient flexible phosphorescent polymer light-emitting diodes based on silver nanowire-polymer composite electrode.

Blue, green, and red electrophosphorescent polymer light-emitting diodes have been fabricated on silver nanowire-polymer composite electrode. The devices are 20%-50% more efficient than control devices on ITO/glass and exhibit small efficiency roll-off at high luminances. The blue PLEDs were repeatedly bent to 1.

Flexible electrically conductive nanocomposite membrane based on bacterial cellulose and polyaniline.

The novel conductive polyaniline/bacterial cellulose (PANI/BC) nanocomposite membranes have been synthesized in situ by oxidative polymerization of aniline with ammonium persulfate as an oxidant and BC as a template. The resulting PANI-coated BC nanofibrils formed a uniform and flexible membrane. It was found that the PANI nanoparticles deposited on the surface of BC connected to form a continuous nanosheath by taking along the BC template, which greatly increases the thermal stability of BC.