Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture.

Purpose: Lipids increase osteoporosis and fracture risk, yet research on Atherogenic Index of Plasma (AIP), bone mineral density declines (BMD), and trabecular bone score (TBS) is limited. This study examined the relationships between AIP, TBS, and BMD in American adults using the National Health and Nutrition Examination Survey (NHANES) data, including the effect of obesity.

Methods: Based on data from 3,162 Americans, multivariable logistic regression and a generalized additive model (GAM) were used to analyze AIP, BMD, and TBS.

Non-linear association of sleep duration with osteoarthritis among U.S. middle-aged and older adults.

Background: The duration of sleep is linked to a range of disorders. Osteoarthritis (OA) stands as one of the most prevalent forms of arthritis and serves as a leading cause of disability. The correlation between the duration of sleep and OA remains ambiguous.

The magnitude and frequency of detected precipitation determine the accuracy performance of precipitation data sets in the high mountains of Asia.

The grid-based precipitation dataset is an important source for studying precipitation change in the high mountains of Asia due to where precipitation stations are sparse. It is essential to evaluate the accuracy of grid-based precipitation datasets in the high mountains of Asia before selecting an appropriate grid-based dataset. Therefore, this study comprehensively evaluated the precipitation errors of four commonly utilized precipitation datasets (multi-source weighted-ensemble precipitation (MSWEP), global precipitation climatology centre (GPCC), global precipitation measurement (GPM), and soil moisture to rain-advanced scatterometer (SM2RAIN-ASCAT)) in the high mountains of Asia from temporal and spatial perspectives.

Global energy use and carbon emissions from irrigated agriculture.

Irrigation is a land management practice with major environmental impacts. However, global energy consumption and carbon emissions resulting from irrigation remain unknown. We assess the worldwide energy consumption and carbon emissions associated with irrigation, while also measuring the potential energy and carbon reductions achievable through the adoption of efficient and low-carbon irrigation practices.

Decreasing trends of mean and extreme snowfall in High Mountain Asia.

Intense warming profoundly alters precipitation phase patterns and intensity in High Mountain Asia (HMA). While snowfall climatology and precipitation extremes have been studied, there is a lack of understanding of snowfall extremes within HMA. Here, we investigate the spatial and temporal variability of non-extreme and extreme snowfall in hydrological years 1979-2020 using multi-source meteorological data, compare weather systems during extreme and non-extreme snowfall events, and identify key circulation factors that influence fluctuations in mean annual snowfall and extreme snowfall.

Spatiotemporal characteristics of meteorological drought events in 34 major global river basins during 1901-2021.

Meteorological drought is a crucial driver of various types of droughts; thus, identifying the spatiotemporal characteristics of meteorological drought at the basin scale has implications for ecological and water resource security. However, differences in drought characteristics between river basins have not been clearly elucidated. In this study, we identify and compare meteorological drought events in 34 major river basins worldwide using a three-dimensional drought-clustering algorithm based on the standardised precipitation evapotranspiration index on a 12-month scale from 1901 to 2021.

Meteorological drought migration characteristics based on an improved spatiotemporal structure approach in the Loess Plateau of China.

The development of drought has spatial and temporal synchronization. Previous studies usually explore the spatial and temporal evolution of drought separately. Moreover, existing approaches are based on a fixed overlapping area and do not consider the variable drought cluster area during development.

Historical and comparative overview of sponge campus construction and future challenges.

Frequent urban flooding has caused great economic losses and casualties worldwide. Sponge cities have attracted attention as an important means of flood control and disaster reduction. This paper systematically and comprehensively analyzes the development of sponge campuses in China and other countries and compares classic examples of sponge campus construction.

Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis.

Background: Circular RNAs (circRNAs) have been shown to play diverse biological functions in the progression of multiple diseases. However, the impacts of circRNAs on breast cancer (BC) progression remains unclear. Therefore, the objective of this paper is to investigate the role and mechanisms of a functional circRNA in BC metastasis and immune escape.

Shifting in the global flood timing.

Climate change will have an impact on not only flood magnitude but also on flood timing. This paper studies the shifting in flood timing at 6167 gauging stations from 1970 to 2010, globally. The shift in flood timing and its relationship with three influential factors (maximum 7-day precipitation, soil moisture excess, and snowmelt) are investigated.

Spatiotemporal variation in irrigation water requirements in the China-Pakistan Economic Corridor.

Agricultural irrigation consumes most of the fresh water in the China-Pakistan Economic Corridor (CPEC), directly affecting water resource management and allocation. Irrigation water demand is a key component of regional water resources management. We analyzed spatiotemporal variation in irrigation water requirement, irrigation demand index (IDI), and the proposed regional optimization of irrigation water use based on the Bayesian probability network.

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface-Enhanced Raman Scattering Substrate.

Exosomes have emerged as potential biomarkers for pancreatic cancer (PaC). However, it is still challenging to get quantitative detection of exosomes with the specific surface receptors. In this study, a highly sensitive detection system is first constructed for the direct quantitation of specific exosomes in real samples using hierarchical surface-enhanced Raman scattering substrate (H-SERS substrate) and rapid enrichment strategy magnetic beads @ exosomes @ SERS detection probes (MEDP).

Exposure Risk of Global Surface O During the Boreal Spring Season.

Unlabelled: Surface ozone (O) is an oxidizing gaseous pollutant; long-term exposure to high O concentrations adversely affects human health. Based on daily surface O concentration data, the spatiotemporal characteristics of O concentration, exposure risks, and driving meteorological factors in 347 cities and 10 major countries (China, Japan, India, South Korea, the United States, Poland, Spain, Germany, France, and the United Kingdom) worldwide were analyzed using the MAKESENS model, Moran' analysis, and Generalized additive model (GAM). The results indicated that: in the boreal spring season from 2015 to 2020, the global O concentration exhibited an increasing trend at a rate of 0.

Exploring sustainable solutions for the water environment in Chinese and Southeast Asian cities.

Water is essential for human activities and economic development, and the water environment significantly influences ecological balance and global climate. China and Southeast Asia are the most populous areas in the world, and their water resources are deteriorating day by day. We focus on five representative cities such as, Beijing, Jakarta, Hanoi, Kathmandu and Manila to investigate water-environmental problems with the ultimate goal of providing recommendations for sustainable urban water management.

The Association of Stage 1 Hypertension, Defined by the 2017 ACC/AHA Guidelines, With Cardiovascular Events Among Rural Women in Liaoning Province, China.

The recent American College of Cardiology/American Heart Association (ACC/AHA) guidelines redefined blood pressure levels 130-139/80-89 mmHg as stage 1 hypertension. However, the association of stage 1 hypertension with cardiovascular disease (CVD) and its age-specific differences among the rural women in Liaoning province remains unclear. It needs to be quantified in considering guideline adoption in China.

Attribution of changes in the trend and temporal non-uniformity of extreme precipitation events in Central Asia.

Extreme precipitation events exhibit an increasing trend for both the frequency and magnitude on global and regional scales and it has already proven the impact of man-made global warming on the extreme precipitation amplification. Based on the observed datasets and global climate model (GCM) output, this study has evaluated the impact from anthropogenic forcing on the trend and temporal non-uniformity (i.e.

A novel long non-coding RNA AC073352.1 promotes metastasis and angiogenesis via interacting with YBX1 in breast cancer.

Breast cancer is the major cause of cancer death worldwide in women. Patients with metastasis have poor prognosis and the mechanisms of breast cancer metastasis are not completely understood. Long non-coding RNAs (lncRNAs) have been shown to have crucial roles in breast cancer development and progression.

Rapidly declining surface and terrestrial water resources in Central Asia driven by socio-economic and climatic changes.

A systematic understanding of the dynamics of surface water resources and terrestrial water storage (TWS) is extremely important for human survival in Central Asia (CA) and maintaining the balance of regional ecosystems. Although several remote sensing products have been used to map surface water, the spatial resolution of some of them (hundreds of meters) is not sufficient to identify small surface water bodies, with monitoring data only being available for a few years or less. Thus, long-term continuous monitoring of surface water dynamics has not yet been achieved.

Genetic rearrangement during site specific integration event facilitates cell line development of a bispecific molecule.

Site specific integration (SSI) expression systems offer robust means of generating highly productive and stable cell lines for traditional monoclonal antibodies. As complex modalities such as antibody-like molecules comprised of greater than two peptides become more prevalent, greater emphasis needs to be placed on the ability to produce appreciable quantities of the correct product of interest (POI). The ability to screen several transcript stoichiometries could play a large role in ensuring high amounts of the correct POI.

Erratum to "Expression Profiles and Ontology Analysis of Circular RNAs in a Mouse Model of Myocardial Ischemia/Reperfusion Injury".

[This corrects the article DOI: 10.1155/2020/2346369.].

Individualized Prediction of Survival by a 10-Long Non-coding RNA-Based Prognostic Model for Patients With Breast Cancer.

Deregulations of long non-coding RNAs (lncRNAs) have been implicated in the progression of breast cancer (BC). However, the prognostic values of those lncRNAs in BC remain elusive. This study aimed at constructing a lncRNA-based prognostic model to improve the clinical management of BC.