Study on the Influence of Injection Velocity on the Evolution of Hole Defects in Die-Cast Aluminum Alloy.

Aluminum alloy die casting has achieved rapid development in recent years and has been widely used in all walks of life. However, due to its high pressure and high-speed technological characteristics, avoiding hole defects has become a problem of great significance in aluminum alloy die casting production. In this paper, the filling visualization dynamic characterization experiment was innovatively developed, which can directly study and analyze the influence of different injection rates on the formation and evolution of alloy flow patterns and gas-induced defects.

Association of metabolites on ischemic stroke subtypes: a 2-sample Mendelian randomization study.

Background: Metabolomics is increasingly being utilized in IS research to elucidate the intricate metabolic alterations that occur during ischemic stroke (IS). However, establishing causality in these associations remains unclear between metabolites and IS subtypes. In this study, we employ Mendelian randomization (MR) to identify specific metabolites and investigate potential causal relationships between metabolites and IS subtypes.

Mn Substitution to Improve NaV(PO)F-Based Electrodes for Sodium-Ion Battery Cathode.

NaV(PO)F (NVPF) is an extremely promising sodium storage cathode material for sodium-ion batteries because of its stable structure, wide electrochemical window, and excellent electrochemical properties. Nevertheless, the low ionic and electronic conductivity resulting from the insulated PO structure limits its further development. In this work, the different valence states of Mn ions (x = 2, 3, 4) doped NVPF were synthesized by the hydrothermal method.

Using 5 consecutive years of NICE guidance to describe the characteristics and influencing factors on the economic evaluation of orphan oncology drugs.

Objective: Orphan oncology drugs used in this article were defined by the type of disease treated by drugs, as drugs used to treat rare diseases with a prevalence of ≤ 500 per million people per year. In this article, our concern was to explore focus on the economic evaluation of the National Institute for Health and Care Excellence (NICE), when orphan oncology drugs were appraised for reimbursement, and provide advice and suggestions to decision-makers.

Methods: A retrospective study was used in this study.

Superb microvascular imaging for detecting carpal tunnel syndrome compared with power Doppler ultrasonography: A protocol for systematic review and meta-analysis.

Background: Sonography enhances diagnostic accuracy by the detection of the epineural or intraneuronal blood flow.[1-4] Power Doppler ultrasonography (PDUS) in carpal tunnel syndrome (CTS) has been previously studied and shown to be valid and reliable for grading the intraneural flow.[3,4] However, superb microvascular imaging (SMI) represents a new era in diagnostic sonography, and this new technology enables accurate visualization of vascular structures with intensive clutter suppression to provide flow signals for large to small vessels, and it presents these data at high frame rates.

Banxia Xiexin Decoction in the treatment of Hp-associated peptic ulcer: A protocol for systematic review and meta-analysis.

Background: Studies suggested Banxia Xiexin Decoction is effective in the treatment of helicobacter pylori (HP) positive peptic ulcer. The present meta-analysis aimed at evaluating the efficacy and safety of Banxia Xiexin decoction in the treatment HP positive peptic ulcer.

Methods: We will search PubMed, Web of Science, Cochrane Library, and Chinese biomedical databases from their inceptions to the November 30th, 2020.

Hotspot Analysis of Traditional Drugs in Diabetes Treatment Literature.

Objective: To summarize current hotspots and predict the potential trends in traditional drugs of diabetes treatment for further research.

Methods: Publications on the application of traditional drugs in diabetes treatment were searched from PubMed without language limits. Highly frequent MeSH terms were identified through Bibliographic Item Co-Occurrence Matrix Builder (BICOMB).

[Effect of electroacupuncture on expression of stromal cell derived factor-1α in focal ischemic cerebral tissue of rats with cerebral ischemia/ reperfusion injury].

Objective: To observe the effect of electroacupuncture (EA) of "Baihui" (GV20) and "Zusanli" (ST36) on the expression of stromal cell derived factor-1α (SDF-1α) and CD34 in ischemic cortex tissue of cerebral ische-mia /reperfusion injury (CI/RI) rats, so as to study its mechanisms underlying improving CI/RI.

Methods: Thirty male SD rats were equally and randomly divided into sham operation, model and EA groups (10 rats in each group). The CI/RI model was established by occlusion of the middle cerebral artery for 120 min, followed by reperfusion.