Publications by authors named "Weika Ge"
Commun Biol
November 2022
Article Synopsis
- Cas12a can process multiple sgRNAs from a single transcript, making it valuable for multiplexed base editing of multiple genes or variants.
- Current usage of Cas12a in base editing is limited due to efficiency issues and a narrow PAM range, but improvements have been made using Lachnospiraceae bacterium Cas12a (LbCas12a) variants.
- The newly developed cytosine and adenine base editor systems allow efficient conversions and enable multiplexed editing in somatic cells and embryos, positioning them as important tools for genetic advancement, disease research, and gene therapy.
