Silk Fibroin Hydrogel for Pulse Waveform Precise and Continuous Perception.

Precise and continuous monitoring of blood pressure and cardiac function is of great importance for early diagnosis and timely treatment of cardiovascular diseases. The common tests rely on on-site diagnosis and bulky equipments, hindering early diagnosis. The emerging hydrogels have gained considerable attention in skin bioelectronics by virtue of the similarities to biological tissues and versatility in mechanical, electrical, and biofunctional engineering.

Extract toolkit for essential oils: State of the art, trends, and challenges.

Plant essential oils have a wide range of applications including cosmetics, food, leather, and textiles. Traditional methods employed for essential oils extraction suffer from several drawbacks, which have escalated into a major bottleneck for industrial applications. To circumvent the limitations, various innovative and eco-friendly technologies have emerged for the extraction of essential oils, such as ultrasound-assisted extraction, pulsed electrical-assisted extraction, ohmic-assisted technology, supercritical fluid extraction, and solvent-free microwave extraction.

An 18.3 MJ charging and discharging pulsed power supply system for the space plasma environment research facility (SPERF): the subsystem for the magnetic mirror coil.

The magnetic reconnection process relevant to that at the magnetotail is one of the research contents of the Space Plasma Environment Research Facility, which is under construction at the Harbin Institute of Technology in China. Two magnetic mirror sub-coils placed symmetrically in the vertical direction and connected in series cooperate with a dipole coil to generate a magnetic field environment similar to the Earth's magnetotail. A capacitor-based pulsed power supply (PPS) system with a modular design is developed to excite two magnetic mirror sub-coils to generate a magnetic field with a magnetic flux density of not less than 200 G at the center of the two sub-coils.

Biodegradable starch-based packaging films incorporated with polyurethane-encapsulated essential-oil microcapsules for sustained food preservation.

Novel starch-based packaging films with sustained antibacterial activity were successfully made by incorporating polyurethane-encapsulated essential-oil microcapsules (EOs@PU) as an alternative synthetic preservative for food preservation. Herein, three essential oils (EOs) were blended to make composite essential oils with a more harmonious aroma and higher antibacterial ability and encapsulated into polyurethane (PU) to form EOs@PU microcapsules based on interfacial polymerization. The morphology of the constructed EOs@PU microcapsules was regular and uniform with an average size of approximately 3 μm, thus enabling high loading capacity (59.

Muscle Contraction-Inspired Tough Hydrogels.

In many animals, tough skeletal muscle contraction occurs, producing a strong force through myofilaments attaching to and sliding on fibrous actin filaments. In contrast, the strength of typical synthetic hydrogels is facilitated mainly by polymeric chains. We propose a strategy for developing strong and tough hydrogels in which the side groups on polymeric chains strongly interact with dispersing medium.

microRNA-497-mediated Smurf2/YY1/HIF2α axis in tumor growth and metastasis of esophageal squamous cell carcinoma.

Aberrant expression of microRNA-497 (miR-497) is associated with tumor progression, but the molecular mechanisms in tumorigenesis remain largely unknown. Here, we report that miR-497 expression is downregulated in esophageal squamous cell carcinoma (ESCC) clinical samples. Consistently, upregulation of miR-497 inhibits ESCC cell malignant properties and tumor growth in vivo.

pH-responsive citral microcapsules with tannic acid-Fe coordination complexes.

Citral is one of the most important aromatic ingredients in foods and beverages for its distinct lemon-like odor. However, the fast evaporation and oxidation limit these applications. Herein, citral microcapsules were constructed by tannic acid-Fe coordination complexes (citral@TA-Fe).

Dual stabilization of Pickering emulsion with epigallocatechin gallate loaded mesoporous silica nanoparticles.

Oxidation in food emulsions remains challenging to keep food quality and shelf-life. In this paper, a dual stabilization to both oil phase and antioxidant in Pickering emulsion is presented. Mesoporous silica nanospheres (MSN) were prepared to incorporate epigallocatechin gallate (EGCG), a typical plant-based antioxidant.

Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data.

Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer associated with an unstable prognosis. Thus, there is an urgent demand for the identification of novel diagnostic and prognostic biomarkers as well as targeted drugs for LUAD. The present study aimed to identify potential new biomarkers associated with the pathogenesis and prognosis of LUAD.

Supersmall Dendritic Mesoporous Silica Nanospheres as Antioxidant Nanocarriers for Pickering Emulsifiers.

Encapsulation of flavor and aromatic compounds in emulsions holds great potential for development of novel formulations in food applications. In this paper, supersmall dendritic mesoporous silica nanospheres (DMSNs) were fabricated by the one-pot strategy. The morphologies of DMSNs were directly tuned in terms of diameter from 35 ± 2 to 85 ± 4 nm.

An 18.3 MJ charging and discharging pulsed power supply system for the Space Plasma Environment Research Facility (SPERF): The subsystem for the magnetic perturbation coils.

The mechanism of acceleration, loss, and wave-particle interaction of energetic particles in the magnetosphere is a research content of the Space Plasma Environment Research Facility, which is being built as a user facility at the Harbin Institute of Technology in China. Two magnetic perturbation coils are used to simulate the magnetic storm distortion and excite Alfvén wave perturbation. A capacitor-based pulsed power supply (PPS) system with a modular design is developed to excite the magnetic perturbation coils to generate the required amplitude and duration of the magnetic field.

An 18.3-MJ charging and discharging pulsed power supply system for the Space Plasma Environment Research Facility (SPERF): The subsystem for the magnetosheath coils.

3D asymmetric magnetic reconnection is an important investigation of the Space Plasma Environment Research Facility, which is being built as a user facility at the Harbin Institute of Technology in China. Four magnetosheath coils, which consist of Poloidal Field (labeled PF) coils and Toroidal Field (labeled TF) coils, are used to generate the magnetic field and plasma environment for the reconnecting experiment. A capacitor-based pulsed power supply (PPS) system with a modular design is developed to excite the magnetosheath coils to generate the required amplitude and duration of the magnetic field.

Chitosan-coated organosilica nanoparticles as a dual responsive delivery system of natural fragrance for axillary odor problem.

Citronellol (CI)-loaded, chitosan (CS)-enclosed dendritic mesoporous organosilica nanoparticles (CI@D-MONs@CS) are successfully fabricated. The synthesized CI@D-MONs@CS present spherical shape with the particle size of 424±24 nm in diameter and dendritic mesopores. CI loading ratio of CI@D-MONs@CS is about 12.

An 18.3 MJ charging and discharging pulsed power supply system for the Space Plasma Environment Research Facility (SPERF): The subsystem for the magnetopause shape control coils.

The Space Plasma Environment Research Facility currently under construction at the Harbin Institute of Technology in China uses four magnetosheath coils (flux cores) and a dipole coil to generate the magnetic field required for the study on the magnetopause magnetic reconnection. Two groups of magnetopause shape control coils (labeled CK coils) are used to slightly adjust the magnetic field distribution on the magnetopause. A capacitive pulsed power supply (PPS) system with a modular design is developed to excite CK coils.

An 18.3 MJ charging and discharging pulsed power supply system for the Space Plasma Environment Research Facility (SPERF): The subsystem for the dipole coil.

The Space Plasma Environment Research Facility (SPERF) currently under construction at the Harbin Institute of Technology in China is a user facility dedicated to studying space plasma physics on the ground. A coil system of the SPERF consists of seven types of coils, which are used to generate the magnetic fields and plasma required by the physical experiments. A dipole coil of the coil system works with four magnetosheath coils (flux cores) to build the magnetic fields resembling that of the Earth and solar wind.

An 18.3 MJ charging and discharging pulsed power supply system for the Space Plasma Environment Research Facility (SPERF): Modular design method and component selection.

The capacitor-based pulsed power supply (PPS) system is an important subsystem of the Space Plasma Environment Research Facility being built as a user facility at Harbin Institute of Technology in China. It has been developed with a modular design to drive magnetic coils to generate magnetic fields and plasma for the physical experiments. In this paper, the modular design and component selection are proposed based on a calculation of parameter ranges of components and the number of modules followed by a simulation and an engineering test.

Complicated appendicitis are common during the epidemic period of 2019 novel coronavirus (2019-nCoV).

Objectives: To assess the prevalence of complicated appendicitis (including gangrene, abscess and perforation) after the outbreak of the 2019-nCoV epidemic and to identify the risk factors associated with complicated appendicitis.

Methods: Two groups were established in the study consisting of: one group for cases of acute appendicitis before the 2019-nCoV epidemic (before January 1, 2020; pre-epidemic group) and another group for those after the epidemic outbreak (after January 1, 2020; epidemic group). These two groups were compared in terms of demographic and clinical characteristics, prevalence of complicated appendicitis, and treatment intention.

Dual responsive linalool capsules with high loading ratio for excellent antioxidant and antibacterial efficiency.

Linalool is a main component in different naturally derived essential oils, and widely used in household, personal care, food and therapeutic formulations. However, the application is limited due to its high volatility and low stability. In this study, an effective encapsulation with high loading ratio was built up together with thermal-redox dual responsiveness and controlled release properties.

Antibacterial and anticancer activities of asymmetric lollipop-like mesoporous silica nanoparticles loaded with curcumin and gentamicin sulfate.

Asymmetric mesoporous silica nanoparticles with anisotropic geometry and dual-compartments are highly desired for loading and release of dual-drugs in separated storage spaces. In this study, an asymmetric lollipop-like mesoporous silica nanoparticle FeO@SiO&EPMO (EPMO = ethane bridged periodic mesoporous organosilica) was successfully developed via an anisotropic epitaxial growth strategy. The asymmetric nanoparticles show a uniform lollipop shape with a head of spherical FeO@SiO core-shell that is 200 nm in diameter and a tail of EPMO nanorods with a length of ∼90 nm, and a specific surface area of ∼650.

miR-92b-3p Functions As A Key Gene In Esophageal Squamous Cell Cancer As Determined By Co-Expression Analysis.

Background: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy. The aims of the present study were to screen the critical miRNA and corresponding target genes that related to development of ESCC by weighted gene correlation network analysis (WGCNA) and investigate the functions by experimental validation.

Methods: Datasets of mRNA and miRNA expression data were downloaded from GEO.

Impact of Bariatric Surgery on Female Sexual Function in Obese Patients: a Meta-Analysis.

We aimed to make a meta-analysis regarding the effect of bariatric surgery on female sexual function. PubMed, EMBASE, and CENTRAL were searched from database inception through August 2019. Articles were eligible for inclusion if they examined the effect of bariatric surgery on obese women's sexual function assessed by the Female Sexual Functioning Index (FSFI) or/and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12).

Role of leptin in allergic rhinitis during sublingual immunotherapy.

Objective: Increasing evidence suggests that leptin is upregulated during allergic reactions in the airway and related to the severity of disease in allergic rhinitis (AR). In this study, we aimed to investigate the expression of leptin during sublingual immunotherapy (SLIT) in AR patients.

Methods: Forty AR patients without obesity were recruited in this study.

Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB.

Hepatocellular carcinoma (HCC) is highly resistant to traditional chemotherapeutic approaches, which causes difficulty in the development of effective drugs for the treatment of HCC. Berberine, a major ingredient of Rhizoma coptidis, is a natural alkaloid used in traditional Chinese medicine. Berberine exhibits potent antitumor activity against HCC due to its high efficiency and low toxicity.

[Experimental study on biomechanical properties of porcine trachea].

This is a study to evaluate the biomechanical properties of porcine trachea; the intention is to provide experimental methods as well as evidence for further studies on human trachea and artificial trachea. In the current study, the biomechanical indices such as bending stiffness, radial pedestal and stress-straining, bursting strength, and residual stress were adopted. The findings were as follows: there is residual stress in the trachea; when the 50mm trachea is compressed 50%, the force of radial pedestal is about 10N; the force of break from cricoid to eminence is from 180mmHg to 110mmHg.

Biomechanical properties of adult-excised porcine trachea for tracheal xenotransplantation.

Background: To investigate and evaluate the biomechanical properties of adult-excised porcine trachea, thereby providing experimental methods and evidence for biomedical engineering of artificial trachea.

Methods: The TY8000 servo-handle tension test machine was used to measure biomechanical indices, such as bending stiffness, radial pedestal, and stress-straining. The residual stress and bursting strength of adult-excised porcine trachea was evaluated.