Publications by authors named "Weijie Hao"

Article Synopsis
  • Timely translation of maternal mRNA is crucial for oocyte maturation and embryonic development; PGC7 is identified as a key maternal factor in this process.
  • PGC7 maintains AKT1 activity and promotes the phosphorylation of the translation inhibitor YBX1, crucial for maternal mRNA translation.
  • The study reveals PGC7’s essential role in regulating the PGC7-AKT1-YBX1 axis, leading to enhanced translation of important maternal proteins like Cyclin B1 and YAP1 in mammalian oocytes.
View Article and Find Full Text PDF
Article Synopsis
  • - Genomic imprinting, crucial for mammalian development, relies on PGC7, a maternal factor that maintains DNA methylation by binding to dimethylated histone H3K9 (H3K9me2) in zygotes and stem cells.
  • - The study identifies that PGC7 interacts with HP1BP3, a novel histone H1 family member, specifically through its C-terminal tail, facilitating recruitment to the Meg3 differentially methylated region (DMR) within the Dlk1-Dio3 imprinted domain.
  • - The combined action of PGC7 and HP1BP3 prevents the binding of DNA methyltransferase DNMT3A, therefore preserving the methylation status of the
View Article and Find Full Text PDF

Background: Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those from obese individuals (O-ADSCs) have not been thoroughly investigated, particularly regarding their mitochondrial and lysosomal functions. Therefore, this study aims to evaluate the differences between L-ADSCs and O-ADSCs in terms of cell biological activity, mitochondria, and lysosomes.

View Article and Find Full Text PDF

Background: N6-methyladenosine (m6A) is the most prevalent RNA modification. Although hnRNPA2B1, as a reader of m6A modification, has been reported to promote tumorigenesis in a few types of tumors, its role in hepatocellular carcinoma (HCC) and the underlying molecular mechanism remains unclear.

Methods: Multiple public databases were used to analyze the expression of hnRNPA2B1 in HCC and its correlation with survival prognosis.

View Article and Find Full Text PDF

Finding new agents to enhance the strength of alkali-activated (ground granulated blast furnace slag) GGBS is beneficial for environmental protection. Here, we reveal the effect of pregelatinized starch-modifying calcium silicate hydrate (C-S-H) particles on the nanostructure tailoring of NaOH-activated GGBS hydrates. The results show that, for the synthetic modified C-S-H, the pregelatinized starch absorbs on the surface of C-S-H, which modifies the silicate chains and crystal structure.

View Article and Find Full Text PDF
Article Synopsis
  • PGC7 (also known as Stella) is a key protein in oocytes that regulates DNA methylation through its interaction with other proteins, particularly in early embryonic development.
  • PGC7 reduces the interaction between YY1 and the PRC2 complex, which is important for modifying histones and controlling gene expression.
  • In the absence of PGC7, zygotes show an increase in H3K27me3 levels, affecting the activation of key genes during the early stages of embryo development.
View Article and Find Full Text PDF
Article Synopsis
  • DNA methylation is an important process that influences gene expression and cellular functions, with PGC7 being a key factor in maintaining this modification during early embryonic development.
  • The study focused on F9 embryonic cancer cells, showing that inhibiting ERK activity or knocking down certain proteins led to higher levels of DNA methylation and changes in the localization of DNMT1, an enzyme involved in methylation.
  • The findings suggest that PGC7 regulates DNA methylation through ERK's phosphorylation of DNMT1, potentially offering new avenues for understanding and treating diseases related to DNA methylation.
View Article and Find Full Text PDF

Introduction: There was limited evidence on the quality of reporting and methodological quality of prediction models using machine learning methods in preterm birth. This systematic review aimed to assess the reporting quality and risk of bias of a machine learning-based prediction model in preterm birth.

Material And Methods: We conducted a systematic review, searching the PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine disk, VIP Database, and WanFang Data from inception to September 27, 2021.

View Article and Find Full Text PDF

Gliomas are the most common primary brain tumors and are highly malignant with a poor prognosis. Pyroptosis, an inflammatory form of programmed cell death, promotes the inflammatory cell death of cancer. Studies have demonstrated that pyroptosis can promote the inflammatory cell death (ICD) of cancer, thus affecting the prognosis of cancer patients.

View Article and Find Full Text PDF

Background: Mesenchymal stem cells (MSCs) have been extensively used for the treatment of various diseases in preclinical and clinical trials. In vitro propagation is needed to attain enough cells for clinical use. However, cell aging and viability reduction caused by long-time culture have not been thoroughly investigated, especially for the function of mitochondria and lysosomes.

View Article and Find Full Text PDF

Background: Psoriasis is a chronic inflammatory skin disease. Tissue stem cells have exhibited a therapeutic effect on psoriatic mice. However, the therapeutic effect of topical administration of the secretome derived from tissue stem cells on psoriasis has not been reported.

View Article and Find Full Text PDF

Background: The shortening of 3' untranslated regions (3'UTRs) of messenger RNAs(mRNAs) by alternative polyadenylation (APA) is an important mechanism for oncogene activation. Cleavage stimulation factor 2 (CSTF2), an important regulator of APA, has been reported to have a tumorigenic function in urothelial carcinoma of the bladder and lung cancers. However, the tumor-promoting role of CSTF2 in hepatocellular carcinoma (HCC) and its underlying molecular mechanism remains unclear.

View Article and Find Full Text PDF

As a cold tumor, malignant glioma has strong immunosuppression and immune escape characteristics. The tumor microenvironment (TME) provides the "soil" for the survival of malignant tumors, and cancer-associated fibroblasts (CAFs) are the architects of matrix remodeling in TME. Therefore, CAFs have potent regulatory effects on the recruitment and functional differentiation of immune cells, whereby they synthesize and secrete numerous collagens, cytokines, chemokines, and other soluble factors whose interaction with tumor cells creates an immunosuppressive TME.

View Article and Find Full Text PDF

HNRNPA2B1, an RNA-binding protein, plays a key role in primary microRNA processing, alternative splicing, mRNA metabolism and transport. Interestingly, hnRNPA2B1 also works as an N6-methyladenosine (m6A) reader and is critical during tumorigenesis of various tissue types. However, its role in colon cancer is still unclear.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionfka7k6h3hmch6dfja7avr3eoqn8otb6e): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once