Publications by authors named "Weijie Cao"

Background: No effective treatment is available to delay or reverse the onset and progression of Alzheimer's dementia (AD). Mild cognitive impairment, a clinical state between normal aging and AD, may offer the proper window for AD intervention and treatment. This systematic review aimed to summarize evidence from Mendelian randomization (MR) studies exploring factors attributable to AD and related cognitive status and to assess its credibility.

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Background: The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders.

Methods: Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked to IBS.

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Background: Acute graft-versus-host disease (aGVHD) is a complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The role of macrophages as proficient antigen-presenting cells in aGVHD is a prominent area of investigation in contemporary research. The association between long noncoding RNA nuclear enriched abundant transcript 1 (lncRNA NEAT1) and the macrophage function is of significant interest.

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  • This study assessed the occurrence of invasive fungal disease (IFD) in patients who received allogeneic stem cell transplants in China during 2021.
  • A total of 2015 patients were involved, with 76% receiving mold-active antifungal prophylaxis, yet the cumulative incidence of IFD was found to be 6.3% within a year post-transplant.
  • Key risk factors for IFD included advanced disease stages, delayed engraftment of neutrophils and platelets, and severe graft-versus-host disease, contributing to an IFD-related mortality rate of 48.28%.
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  • In the last two years, 39,918 hematopoietic stem cell transplantation (HSCT) cases were reported, with 18,194 in 2022 and 21,714 in 2023, showing an increase in procedures.
  • Autologous HSCT made up 31% (6562 cases) in 2022, while allogeneic HSCT accounted for 69% (12,632 cases), with allogeneic continuing to dominate in 2023.
  • Acute leukemia was the most common reason for HSCT, with acute myeloid leukemia (AML) as the top condition; the primary source of stem cells was peripheral blood, and a BuCy-based conditioning regimen was most widely
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Systems biology and multiomics research expand the prospects of planetary health innovations. In this context, this mini-review unpacks the twin scholarships of glycomedicine and precision medicine in the current era of single-cell multiomics. A significant growth in glycan research has been observed over the past decade, unveiling and establishing co- and post-translational modifications as dynamic indicators of both pathological and physiological conditions.

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Background: mutations can be detected in premalignant hematopoietic stem cells and are primarily associated with clonal hematopoiesis of indeterminate potential; however, current evidence does not support assigning them to a distinct European Leukemia Net (ELN) prognostic risk stratification. CD7 is a lymphoid antigen expressed on blasts in approximately 30% of acute myeloid leukemia (AML), and its role in AML remains unclear and depends on subgroup evaluation. This study investigated the prognostic value of mutation combined with CD7 expression in AML.

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Background: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have been inconsistent and may face the bias of confounding and reverse causality. The potential causal relationships between IBD and the risk of cancers remain largely unclear.

Methods: We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR), and colocalization analyses using summary genome-wide association study (GWAS) data across East Asian and European populations to evaluate the causal relationships between IBD and cancers.

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Introduction Bispecific antibodies (BsAbs) represent a novel and potentially effective approach in cancer immunotherapy. These antibodies feature two unique binding domains, enabling them to simultaneously attach to two antigens or two epitopes of a single antigen. Recently, a variety of BsAbs targeting distinct B-cell antigens and myeloid lineage-specific surface markers-such as CD19xCD3, CD38xCD3, and CD123xCD3-have demonstrated promising results in heavily pretreated relapsed/refractory acute lymphoblastic leukemia (R/R ALL) and relapsed/refractory acute myeloid leukemia (R/R AML) patients.

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  • CAR-T cells are a special type of treatment for certain blood cancers, but some people can’t use them due to problems like high costs or manufacturing issues.
  • A study tested a new kind of CAR-T cell (called nU-CAR-T19) that seems to work well in patients with hard-to-treat cancers, helping some go into complete remission.
  • This new CAR-T treatment is safe and showed no signs of severe side effects in the patients, which is a positive development for cancer therapy.
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  • The study aimed to investigate the link between rectal swab culture results and 30-day survival rates in hematologic patients with carbapenem-resistant organism (CRO) bloodstream infections.
  • A total of 434 hematological patients with Gram-negative bacilli bloodstream infections were analyzed, identifying 96 cases of carbapenem-resistant infections, with a noteworthy 75% correlation between positive rectal swabs and matching blood cultures.
  • The findings revealed a significant reduction in 30-day mortality rates when patients had positive rectal culture results before the bloodstream infection, highlighting the importance of early screening and treatment.
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Low Pt-based alloy catalysts are regarded as an efficient strategy in achieving high activity for the oxygen reduction reaction (ORR) in proton-exchange membrane fuel cells (PEMFCs). However, the desired durability for the low Pt-based catalysts, such as the PtCo catalyst, has still been considered a great challenge for PEMFCs. In this study, we investigate sub-2.

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We retrospectively analyzed the outcomes of 136 consecutive patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at our center. Among them, 76 cases used hypomethylating agents (decitabine,  = 40; azacitidine,  = 36) as post-transplant maintenance therapy, whereas 60 contemporaneous patients did not adopt maintenance therapy. The 3-year incidences of relapse in two groups were 16.

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Externalizing traits have been related with the outcomes of coronavirus disease 2019 (COVID-19) and Alzheimer's dementia (AD); however, whether these associations are causal remains unknown. We used the two-sample Mendelian randomization (MR) approach with more than 200 single-nucleotide polymorphisms (SNPs) for externalizing traits to explore the causal associations of externalizing traits with the risk of COVID-19 (infected COVID-19, hospitalized COVID-19, and severe COVID-19) or AD based on the summary data. The inverse variance-weighted method (IVW) was used to estimate the main effect, followed by several sensitivity analyses.

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  • The study aimed to explore risk factors for oral ulcers and bloodstream infections in hematopoietic stem cell transplant patients.
  • The research included 401 patients, revealing a high incidence of oral ulcers (61.3%) and a notable rate of bloodstream infections (9.0%), with various strains of bacteria identified.
  • Key findings indicated that factors like age (≥14 years), leukemia diagnosis, and allogeneic transplants increased the risk of oral ulcers, while maintaining good oral hygiene was linked to a lower risk of bloodstream infections.
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The classic BCR-ABL1-negative myeloproliferative neoplasm (MPN) is a highly heterogeneous hematologic tumor that includes three subtypes, namely polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF). Despite having the same JAK2 mutation, the clinical manifestations of these three subtypes of MPN differ significantly, which suggests that the bone marrow (BM) immune microenvironment may also play an important role. In recent years, several studies have shown that peripheral blood monocytes play an important role in promoting MPN.

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Background: BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of patients. However, the short remission time and high relapse rate of MM patients treated with BCMA CAR-T remain bottlenecks that limit long-term survival. The immune microenvironment of the bone marrow (BM) in R/R-MM may be responsible for this.

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Background: Observational studies demonstrated a bidirectional association between type 2 diabetes (T2D) and hypertension, whereas Mendelian randomization (MR) analyses supported the causality from T2D to hypertension but not causal from hypertension to T2D. We previously found that IgG N-glycosylation is associated with both T2D and hypertension, and thus IgG N-glycosylation might link the causality between them.

Methods: We carried out a genome-wide association study (GWAS) to identify IgG N-glycosylation-quantitative-trait loci (QTLs) integrating GWAS for T2D and hypertension and then performed bidirectional univariable and multivariable MR analyses to infer the causal association among them.

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In adults with acute lymphoblastic leukemia (ALL), post-transplant relapse is a major risk factor for mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our study investigated the efficacy and safety of decitabine (dec) with ALL patients post-transplantation. We performed a retrospective cohort study to assess the efficacy of decitabine (dec) with post-transplant ALL at the First Affiliated Hospital of Zhengzhou University from February 2016 to September 2021.

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Context: There is little evidence regarding the joint effect of serum adipocyte fatty acid binding protein (A-FABP) levels and obesity phenotype on the risk of cardiovascular events.

Objective: To explore the association between serum A-FABP levels and obesity phenotype defined by fat percentage (fat%) and visceral fat area (VFA), and their joint impact on incident cardiovascular events.

Methods: A total of 1345 residents (579 men and 766 women) without previous cardiovascular diseases at baseline, with body composition and serum A-FABP data available, were included.

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Background: The risk of cardiovascular diseases has rapidly increased among middle-aged and elderly. However, little is known about the relationship of body composition changes with the risk of cardiovascular events among this population in China. We explored the associations of 2-year changes in fat percentage (fat%) and fat-free mass percentage (FFM%) with subsequent cardiovascular events in a middle-aged and elderly community-based cohort.

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