Publications by authors named "Weijiao Mou"
The VDR/FFAR2 axis mitigates sepsis-induced lung injury by suppressing macrophage lipid peroxidation.
Int Immunopharmacol
December 2024
Article Synopsis
- Sepsis-induced lung injury results from excessive macrophage activation and leads to inflammation and oxidative damage, with no effective treatments currently available.
- The study investigates the role of the FFAR2 receptor as an anti-inflammatory biomarker and finds that the transcription factor VDR enhances FFAR2 expression, which helps reduce lipid peroxidation in macrophages.
- Experiments show that activating the VDR/FFAR2 pathway can decrease inflammation and lung injury in models of sepsis, suggesting FFAR2 could be a promising target for treatment.