Publications by authors named "Weijia Yu"

Article Synopsis
  • The study aimed to investigate the relationship between acute-phase reactions (APRs) from the first-time use of zoledronate (ZOL) and its effectiveness in improving bone mineral density (BMD) in postmenopausal women with osteoporosis.* -
  • It involved 108 women, focusing on demographic data, APRs, blood markers, and BMD, and found no direct link between APRs and BMD, but noted that body temperature changes after ZOL treatment correlated positively with BMD improvements at 12 months.* -
  • The research concluded that an increase in body temperature after ZOL administration could indicate better BMD outcomes, with specific temperature thresholds being useful for predicting clinically significant changes in bone density.*
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The clinical application of the recombinant human granulocyte colony-stimulating factor (rhG-CSF) is restricted by its short serum half-life. Herein, site-selective modification of the N-terminus of rhG-CSF with PAL-PEG-Ph-CHO was used to develop a long-acting rhG-CSF. The optimized conditions for rhG-CSF modification with PAL-PEG-Ph-CHO were: reaction solvent system of 3% (w/v) Tween 20 and 30 mM NaCNBH in acetate buffer (20 mmol/L, pH 5.

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Persistent pressure overload commonly leads to pathological cardiac hypertrophy and remodeling, ultimately leading to heart failure (HF). Cardiac remodeling is associated with the involvement of immune cells and the inflammatory response in pathogenesis. The macrophage-1 antigen (Mac-1) is specifically expressed on leukocytes and regulates their migration and polarization.

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We investigated the effect of eldecalcitol on disuse muscle atrophy. C57BL/6J male mice aged 6 weeks were randomly assigned to control, tail suspension (TS), and TS-eldecalcitol-treated groups and were injected intraperitoneally twice a week with either vehicle (control and TS) or eldecalcitol at 3.5 or 5 ng for 3 weeks.

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Article Synopsis
  • Patients with multiple myeloma (MM) receive mRNA vaccines to decrease COVID-19 mortality, but their immune responses to vaccination can vary significantly.
  • A study analyzed immune cells from 58 MM patients during and after vaccination and breakthrough infections, revealing that successful vaccine responders had distinct immune cell profiles with strong cytokine responses.
  • The findings suggest that both vaccinated patients and those who experienced breakthrough infections showed similar immune patterns, highlighting potential avenues for improving vaccination strategies for immunocompromised individuals.
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In the past decade, biochar has been widely regarded as a new type of soil conditioner that can effectively control soil acidification and alleviate Al toxicity. Hydrochar is identified as a more economical carbon material than pyrochar, but its effect on Al toxicity and the associated mechanism have not been studied. Thus, a two-stage indoor incubation experiment was conducted to investigate the effect of rice-straw hydrochar (HC, application rate: 1/2/3 %) on maize seedling root growth, soil solution Al activity, soil exchangeable Al and pH buffering ability in acidic red soils from two sites.

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  • Leukocyte infiltration is a key early step in cardiac remodeling, which can lead to heart failure, and the specific role of the integrin CD11b in this process is explored.
  • The study used various mouse models to examine the effects of CD11b knockout and pharmacological treatments on cardiac remodeling induced by hypertension.
  • Results indicated that blocking CD11b significantly reduced cardiac damage and inflammation, suggesting that targeting this integrin could be a potential therapeutic strategy for heart failure.
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Cardiac remodeling is an important mechanism of heart failure, which frequently results from leukocyte infiltration. Vascular cellular adhesion molecule-1 (VCAM-1) plays a critical role in leukocyte adhesion and transmigration. However, the importance of VCAM-1 in the development of angiotensin II (Ang II)-induced cardiac remodeling remains unclear.

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  • The study investigated the links between oxytocin (OT), bone health, and osteoporosis risk in Chinese adult women, focusing on differences between premenopausal and postmenopausal groups.
  • Results showed that premenopausal women had significantly higher serum OT, estradiol levels, and bone mineral density (BMD) compared to postmenopausal women, indicating a potential protective effect.
  • The findings suggest that higher OT levels are associated with better BMD, particularly in the hip region of premenopausal women, highlighting OT's potential role in osteoporosis prevention and treatment.
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Elderly male patients are susceptible to develop osteoporosis and sarcopenia, especially those with fragility fractures, hypogonadism, and prostate cancer with androgen deprivation therapy. However, at present, very few treatments are available for men with sarcopenia. Previous preclinical studies in ovariectomized rats have shown the promising effects of eldecalcitol in ameliorating the bone strength and muscle atrophy.

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Flow cytometry is a powerful technology that allows not only multiparameter quantitative data analysis at single cell resolution but also simultaneous cell separation of different populations of interest at high speed. It has been rapidly employed in biological research and clinical diagnostics. This technology has enabled the thorough understanding of murine hematopoiesis, especially the physiology of surface marker-defined hematopoietic stem and progenitor cell populations.

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Introduction: Hip fracture is one of the leading causes of death and disability in the elderly. We analyzed the risk factors of mortality and second fracture within 2 years after hip fracture surgery in elderly Chinese patients.

Materials And Methods: A total of 613 elderly patients after hip fracture surgery were selected, including 181 males and 432 females, and the patients were followed for at least 24 months.

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The clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) is limited by its short serum half-life. In this study, a long-acting strategy for site-specific modification of rhG-CSF with 1-pentadecyl-1H-pyrrole-2,5-dione (C15 fatty chain-maleimide, C15-MAL) was studied in mixed DMSO-aqueous solutions. The factors influencing the conjugation reaction were investigated and optimized, and a high yield of the desired product (C15-rhG-CSF) was achieved.

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Cardiac lymphatic vessel growth (lymphangiogenesis) and integrity play an essential role in maintaining tissue fluid balance. Inhibition of lymphatic lymphangiogenesis is involved in cardiac edema and cardiac remodeling after ischemic injury or pressure overload. However, whether lymphatic vessel integrity is disrupted during angiotensin II- (Ang II-) induced cardiac remodeling remains to be investigated.

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Adhesion of monocytes to the vascular endothelium frequently leads to an inflammatory response, which contributes to hypertension and vascular remodeling. Vascular cellular adhesion molecule-1 (VCAM-1) plays an important role in leukocyte adhesion and migration during inflammatory diseases. However, its role in angiotensin (Ang) II -induced hypertension and vascular dysfunction remains largely unknown.

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Despite a high clinical need for the treatment of colorectal carcinoma (CRC) as the second leading cause of cancer-related deaths, targeted therapies are still limited. The multifunctional enzyme Transglutaminase 2 (TGM2), which harbors transamidation and GTPase activity, has been implicated in the development and progression of different types of human cancers. However, the mechanism and role of TGM2 in colorectal cancer are poorly understood.

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Purpose: Neuropathic pain causes great distress among patients; however, its response to traditional analgesia techniques remains sub-optimal. There has been progress in stem cell research for neuropathic pain treatment; however, effective homing remains problematic. This study aimed to establish FeO@polydopamine(PDA)-labeled mesenchymal stem cells (MSCs); moreover, we aimed to guide MSCs using a magnetic field to the spinal cord segments showing pain-related responses to allow MSC homing and gathering, in advance, in order to fully employ their repair function.

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G protein-coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive. We found GPR182 to be expressed in microvascular and lymphatic endothelial cells of most organs and to bind with nanomolar affinity the chemokines CXCL10, CXCL12, and CXCL13. In contrast to conventional chemokine receptors, binding of chemokines to GPR182 did not induce typical downstream signaling processes, including G- and G-mediated signaling or β-arrestin recruitment.

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As epigenetic regulators are frequently dysregulated in acute myeloid leukemia (AML) we determined expression levels of the JmjC-protein NO66 in AML cell lines and sub fractions of healthy human hematopoietic cells. NO66 is absent in the AML cell lines KG1/KG1a which consist of cells with the immature CD34/CD38 phenotype and is regarded as a "stem cell-like" model system. Similarly, NO66 is not detectable in CD34/CD38 cells purified from healthy donors but is clearly expressed in the more committed CD34/CD38 cell population.

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Introduction: Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) could affect differentiation of osteoblasts and bone mass through potentiating Wnt/β-catenin signaling. LGR4 is also relevant to glycolipid metabolism. The present study aims to explore the relationship between genetic variations in LGR4 gene and peak bone mineral density (peak BMD) and body composition phenotypes in Chinese nuclear families.

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Inactivating mutations in phosphate-regulating gene with homologies to endopeptidase on the X chromosome (PHEX) have been identified as a cause of X-linked hypophosphatemic rickets (XLH; OMIM 307800). In the present study, we enrolled 43 patients from 18 unrelated families clinically diagnosed with hypophosphatemic rickets and 250 healthy controls. For each available individual, all 22 exons with their exon-intron boundaries of the PHEX gene were directly sequenced.

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Over the recent decades, China experienced several emerging virus outbreaks including those caused by the severe acute respiratory syndrome- (SARS-) coronavirus (Cov), H5N1 virus, and H7N9 virus. The SARS tragedy revealed faults in China's infectious disease prevention system, propelling the Chinese government to enact reforms that enabled better combating of the subsequent H1N1 and H7N9 avian flu epidemics. The system is buttressed by three fundamental, mutually reinforcing components: (1) enduring government administration reforms, including legislation establishing a unified public health emergency management system; (2) prioritized funding for biotechnology and biomedicine industrialization, especially in the areas of pathogen identification, drug production, and the development of vaccines and diagnostics; and (3) increasing investment for public health and establishment of a rapid-response infectious diseases prevention and control system.

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Pseudoachondroplasia (PSACH; MIM no. 177170) is an autosomal dominant osteochondrodysplasia characterized by short‑limb short stature, brachydactyly and early‑onset osteoarthropathy. Typically, at approximately two years of age, the rate of growth falls below the standard growth curve, causing a moderately severe form of disproportionate short‑limb short stature.

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Tumor-induced osteomalacia (TIO) is a rare acquired form of hypophosphatemic osteomalacia, which is usually attributed to the overproduction of fibroblast growth factor 23 (FGF-23) by benign mesenchymal neoplasms. Localization and thereafter surgical resection of tumors lead to a cure. The present study aimed to investigate the clinical data, diagnostic methods, and follow-up after tumor resection at one medical center in Shanghai to characterize the profile of this rare disorder and to share our successful experience in diagnosis and treatment.

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Background: The value of gamma probes in the surgical treatment of secondary hyperparathyroidism (sHPT) was determined.

Method: We retrospectively analyzed the clinical data of 48 sHPT patients between May 2007 and September 2011. Preoperative (99)Tc(m)- methoxyisobutyl isonitrile (MIBI) scintigraphy and high-frequency ultrasonography were used for parathyroid localization.

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