Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery.

Circular bivalent aptamers (cb-apt) comprise an emerging class of chemically engineered aptamers with substantially improved stability and molecular recognition ability. Its therapeutic application, however, is challenged by the lack of functional modules to control the interactions of cb-apt with therapeutics. We present the design of a β-cyclodextrin-modified cb-apt (cb-apt-βCD) and its supramolecular interaction with molecular therapeutics via host-guest chemistry for targeted intracellular delivery.

Aptamer-mediated selective delivery of a cytotoxic cationic NHC-Au(i) complex to cancer cells.

A novel cationic NHC-Au(i) complex was synthesized and studied for its antitumor activity. For all the cell lines tested, cationic NHC-Au(i) complex 2 shows much higher cytotoxicity than its neutral analogue 1. To achieve selective cancer cell targeting, complex 2 was covalently conjugated to aptamer AS1411, a DNA aptamer with strong binding affinity for nucleolin.

N-Heterocyclic Carbene-Gold(I) Complexes Conjugated to a Leukemia-Specific DNA Aptamer for Targeted Drug Delivery.

This report describes the synthesis and characterization of novel N-heterocyclic carbene (NHC)-gold(I) complexes and their bioconjugation to the CCRF-CEM-leukemia-specific aptamer sgc8c. Successful bioconjugation was confirmed by the use of fluorescent tags on both the NHC-Au(I) complex and the aptamer. Cell-viability assays indicated that the NHC-Au(I) -aptamer conjugate was more cytotoxic than the NHC-gold complex alone.

N-heterocyclic carbene gold(I) and silver(I) complexes bearing functional groups for bio-conjugation.

This work describes several synthetic approaches to append organic functional groups to gold and silver N-heterocyclic carbene (NHC) complexes suitable for applications in biomolecule conjugation. Carboxylate appended NHC ligands (3) lead to unstable Au(I) complexes that convert into bis-NHC species (4). A benzyl protected carboxylate NHC-Au(I) complex 2 was synthesized but deprotection to produce the carboxylic acid functionality could not be achieved.

Assembly of one novel polyoxometalate-based inorganic-organic compound from copper-Schiff base building block: synthesis, crystal structure and spectral properties.

A novel copper(II) inorganic-organic hybrid compound [CuL(DMF)(CH(3)OH)](2)(PMo(V)Mo(VI)(11)O(40))·2DMF (L=phenyl 2-pyridyl ketone azine) 1 has been synthesized and characterized by IR, UV, elemental analysis and X-ray crystallography. Cu(II) atom has a distorted square pyramidal environment interconnecting with N(3)O(2) donor set. In solid-state there are three types of C-H···π interactions between adjacent [CuL(DMF)(CH(3)OH)](2+), which generate a two-dimensional (2D) layer.

Two one-dimensional d¹⁰-metal coordination polymers based on polydentate Schiff-base ligand: synthesis, crystal structure and luminescent properties.

Two one-dimensional d(10)-metal coordination polymers {[AgL(H(2)O)](2)[AgL(NO(3))](2)(NO(3))(2)L(H(2)O)(2)}(n) (1) and [ZnLCl(2)](n) (2) (L=N,N'-bis-(1-pyridin-4-yl-ethylidene)-hydrazine) have been synthesized and characterized by IR, elemental analysis, TG technique, XRPD and X-ray crystallography. Polymer 1 contains two types of 1D Ag-double-chain units. Ag(1)-double-chain unit is formed by linking two adjacent Ag(1)-L-chains through face-to-face π⋯π interactions, while Ag(2)-double-chain unit is formed through the combination of coordinating NO(3)(-) anions bridging interactions and π⋯π interactions between two adjacent Ag(2)-L-chains.