Cholesterol lowering in diet-induced hypercholesterolemic mice using bile salt hydrolases with different substrate specificities.

The cholesterol-lowering effect of lactic acid bacteria with high activity of bile salt hydrolase (BSH) is unclear. We believe that distinguishing BSH substrate specificity is necessary to study the effect of various BSH enzymes. We engineered a BSH mutant enzyme recombinant strain named F67A, which exclusively hydrolyzes taurocholic acid (TCA) using site-directed mutagenesis, and a previously lab-constructed BSH recombinant strain, YB81 that exclusively hydrolyzes glycocholic acid (GCA).

Geomagnetic secular variation forecast using the NASA GEMS ensemble Kalman filter: A candidate SV model for IGRF-13.

Abstract: We have produced a 5-year mean secular variation (SV) of the geomagnetic field for the period 2020-2025. We use the NASA Geomagnetic Ensemble Modeling System (GEMS), which consists of the NASA Goddard geodynamo model and ensemble Kalman filter (EnKF) with 400 ensemble members. Geomagnetic field models are used as observations for the assimilation, including (1590-1960), CM4 (1961-2000) and CM6 (2001-2019).

Geodetic evidence that Mercury has a solid inner core.

Geodetic analysis of radio tracking measurements of the MESSENGER spacecraft while in orbit about Mercury has yielded new estimates for the planet's gravity field, tidal Love number, and pole coordinates. The derived right ascension ( = 281.0082° ± 0.

Assessment of the effect of three-dimensional mantle density heterogeneity on earth rotation in tidal frequencies.

In this paper we report the assessment of the effect of the three-dimensional (3D) density heterogeneity in the mantle on Earth Orientation Parameters (EOP) (i.e., the polar motion, or PM, and the length of day, or LOD) in the tidal frequencies.