Prior heatwave exposure improves hypoxia tolerance in a typical freshwater fish species.

The prevalence of heatwave and hypoxia events and their devastating impacts on aquatic ecosystems and fishery resources reinforces the priority of research to address the resilience and adaption mechanisms to these two stressors in important fish species. However, our understanding of the development of cross-tolerance of these two stressors in fish still limited. Here, we investigated the impacts of prior heatwave exposure on hypoxia tolerance and the underlying mechanisms in silver carp (Hypophthalmichthys molitrix), a species of considerable ecological and commercial importance.

Clinical and imaging markers for the prognosis of acute ischemic stroke.

Background And Purpose: Significant differences in the outcomes observed in patients with acute ischemic stroke (AIS) have led to research investigations for identifying the predictors. In this retrospective study, we aimed to investigate the relationship of different clinical and imaging factors with the prognosis of AIS.

Materials And Methods: All clinical and imaging metrics were compared between the good and poor prognosis groups according to the modified Rankin Scale (mRS) score at 90 days after discharge.

Prediabetes and the incidence of Parkinson's disease: A meta-analysis.

Diabetes has been associated with an elevated risk of Parkinson's disease (PD), yet the relationship between prediabetes (PreD) and the incidence of PD in the adult population remains unclear. Therefore, a systematic review and meta-analysis was conducted to evaluate if PreD is also associated with a higher risk of PD. We conducted comprehensive searches of the PubMed, Embase, and Web of Science databases to identify relevant observational studies with longitudinal follow-up.

Ulinastatin Inhibits the Proliferation, Invasion and Phenotypic Switching of PDGF-BB-Induced VSMCs via Akt/eNOS/NO/cGMP Signaling Pathway.

Background: Atherosclerosis is a chronic inflammatory disease responsible for thrombosis, blood supply disorders, myocardial infarction and strokes, eventually leading to increased deaths and reduced quality of life. As inflammation plays a vital role in the development of this disease, the present study aims to investigate whether urinary trypsin inhibitor (UTI) with anti-inflammatory property can inhibit the proliferation, invasion and phenotypic switching of PDGF-BB-induced vascular smooth muscle cells (VSMCs) and probe its potential mechanism.

Methods: Western blot was used to detect the expressions of the proteins related to the Akt/eNOS/NO/cGMP signaling pathway, phenotypic switching and proliferation.

Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction.

The present study established a mouse model of cerebral infarction by middle cerebral artery occlusion, and monitored the effect of 25 μg/kg leukemia inhibitory factor and (or) basic fibroblast growth factor administration 2 hours after model establishment. Results showed that following administration, the number of endogenous neural stem cells in the infarct area significantly increased, malondialdehyde content in brain tissue homogenates significantly decreased, nitric oxide content, glutathione peroxidase and superoxide dismutase activity significantly elevated, and mouse motor function significantly improved as confirmed by the rotarod and bar grab tests. In particular, the effect of leukemia inhibitory factor in combination with basic fibroblast growth factor was the most significant.

Basic fibroblast growth factor increases the number of endogenous neural stem cells and inhibits the expression of amino methyl isoxazole propionic acid receptors in amyotrophic lateral sclerosis mice.

This study aimed to investigate the number of amino methyl isoxazole propionic acid (AMPA) receptors and production of endogenous neural stem cells in the SOD1(G93AG1H) transgenic mouse model of amyotrophic lateral sclerosis, at postnatal day 60 following administration of basic fibroblast growth factor (FGF-2). A radioligand binding assay and immunohistochemistry were used to estimate the number of AMPA receptors and endogenous neural stem cells respectively. Results showed that the number of AMPA receptors and endogenous neural stem cells in the brain stem and sensorimotor cortex were significantly increased, while motor function was significantly decreased at postnatal days 90 and 120.

[Psychological and physical presentations of severe acute respiratory syndrome].

Objective: To study the relation between psychological symptoms and physical parameters in patients with severe acute respiratory syndrome (SARS) at different stages of the disease.

Methods: Physical parameters such as SCL-90, chest CT, T lymphocytes and subset and SaO2 were studied in 29 SARS patients at three different stages (initial stage, serious stage, rehabilitating stage).

Results: Patients with SARS showing severe psychological symptoms constituted about 41% (group I) and patients with SARS showing mild psychological symptoms (group II) constituted about 59%.

[Studies on the chemical constituents of Angelica sinensis].

Aim: To investigate the chemical components of Agelica sinensis.

Methods: Chromatographic technologies were used for separation and purification, while spectral analysis was measured for structure elucidation.

Results: Five compounds were isolated and their structures were identified as Homosenkyunolide H (1), Homosenkyunolide I(2), Neoligustilide (3), 6-methoxycoumarin (4), Hypoxanthine-9-beta-D-ribofuranoside (5).

Establishment of a predictive model of serum glucose changes under different exercise intensities and durations among patients with type 2 diabetes mellitus.

Regular exercise is regarded as one of necessary elements in treating diabetes mellitus (DM). The purpose of this study was to investigate the influence of different exercise intensities and durations on serum glucose changes after exercise in type 2 DM patients and to establish a predictive model of changes in serum glucose under different exercise intensities and durations. Thirty-seven type 2 DM patients were recruited from four teaching hospitals.