Appl Radiat Isot
December 2024
When employing the TDCR method for standardization of low-activity liquid scintillation samples, fluctuations in system background can significantly impact both measurement uncertainties and minimum detectable activity (MDA). To mitigate this impact, a TDCR counting system with anti-coincidence detectors was developed. By analyzing the time difference distribution spectrum between the anti-coincidence channel and β channel, optimal parameters for the anti-coincidence module are determined.
View Article and Find Full Text PDFObjective: To develop and validate a nomogram for quantitively predicting lymphovascular invasion (LVI) of breast cancer (BC) based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomics and morphological features.
Methods: We retrospectively divided 238 patients with BC into training and validation cohorts. Radiomic features from DCE-MRI were subdivided into A1 and A2, representing the first and second post-contrast images respectively.
Proc Natl Acad Sci U S A
July 2023
Accurately obtaining the pollution sources and their contribution rates is the basis for refining watershed management. Although many source analysis methods have been proposed, a systematic framework for watershed management is still lacking, including the complete process of pollution source identification to control. We proposed a framework for identification and abatement of pollutants and applied in the Huangshui River Basin.
View Article and Find Full Text PDFThe majority of mammalian genes encode multiple transcript isoforms that result from differential promoter use, changes in exonic splicing, and alternative 3' end choice. Detecting and quantifying transcript isoforms across tissues, cell types, and species has been extremely challenging because transcripts are much longer than the short reads normally used for RNA-seq. By contrast, long-read RNA-seq (LR-RNA-seq) gives the complete structure of most transcripts.
View Article and Find Full Text PDFSoil heavy metal(loid)s contamination caused by rapid urbanization and industrialization seriously affects human health and hinders the global sustainable development goals (SDGs). Currently, there is a lack of comprehensive human health risk assessment (HHRA) studies for multiple land use types at the regional scale. We propose a practical risk assessment framework that integrates empirical Bayesian kriging (EBK), pollution level analyses, and modified HHRA modeling.
View Article and Find Full Text PDFBackground: Lymphovascular invasion (LVI) is an invasive biologic behavior that affects the treatment and prognosis of patients with early-stage lung cancer. This study aimed to identify LVI diagnostic and prognostic biomarkers using deep learning-powered 3D segmentation with artificial intelligence (AI) technology.
Methods: Between January 2016 and October 2021, we enrolled patients with clinical T1 stage non-small cell lung cancer (NSCLC).
Objective: The standard treatment for stage II-III gastroesophageal junction adenocarcinoma (GEJA) remains controversial, and the role of radiotherapy (RT) in stage II-III GEJA is unclear. Herein, we aimed to evaluate the prognosis of different RT sequences and identify potential candidates to undergo neoadjuvant RT (NART) or adjuvant RT (ART).
Materials And Methods: In total, we enrolled 3,492 patients with resectable stage II-III GEJA from the Surveillance, Epidemiology, and End Results (SEER) database, subsequently assigned to three categories: TN, TN, and TN.
Background: Deep learning algorithms (DLAs) could enable automatic measurements of solid portions of mixed ground-glass nodules (mGGNs) in agreement with the invasive component sizes measured during pathologic examinations. However, the measurement of pure ground-glass nodules (pGGNs) based on DLAs has rarely been reported in the literature.
Purpose: To evaluate the use of a commercially available DLA for the automatic measurement of pGGNs on computed tomography (CT).
In order to meet the demand of on-site measurement for radionuclides, a portable liquid scintillation TDCR system was developed at National Institute of Metrology (NIM), China. The system consists small size TDCR counter for the measurement of liquid scintillation sources, and digital electronics for pulse signal processing. The optical chamber adopts Teflon material with high diffuse reflection efficiency.
View Article and Find Full Text PDFRecently, China advanced a policy of establishing a protected area system with national parks as the main body, and so the development of protected areas has entered a transitional period. However, to promote the coordinated development of economic construction and ecological protection of protected areas, their management needs to be more comprehensive and refined. Therefore, a more quantitative and refined spatial planning and management method for protected areas is urgently needed.
View Article and Find Full Text PDFPurpose: Cell-free DNA (cfDNA) offers a noninvasive approach to monitor cancer. Here we develop a method using whole-exome sequencing (WES) of cfDNA for simultaneously monitoring the full spectrum of cancer treatment outcomes, including minimal residual disease (MRD), recurrence, evolution, and second primary cancers.
Experimental Design: Three simulation datasets were generated from 26 patients with cancer to benchmark the detection performance of MRD/recurrence and second primary cancers.
Cell-free DNA (cfDNA) is attractive for many applications, including detecting cancer, identifying the tissue of origin, and monitoring. A fundamental task underlying these applications is SNV calling from cfDNA, which is hindered by the very low tumor content. Thus sensitive and accurate detection of low-frequency mutations (<5%) remains challenging for existing SNV callers.
View Article and Find Full Text PDFImplementing an integrated assessment system for the carrying capacity of water environments should include recognizing and eliminating warning signs based on future predictions. However, existing methodologies tend to ignore the warning methods already in place, and current studies fail to quantify water ecology issues adequately. To help solve these problems, the ecological footprint that involves water uses a procedural indicator system, which adopts an early warning methodology system approach.
View Article and Find Full Text PDFBurial of organic carbon (OC) in rift lakes on plateau is an important part of the global cycle. It is affected by natural and anthropogenic factors. In this study, we selected the sediment records of 7 rift lakes on the Yunnan-Guizhou Plateau to study spatial-temporal variation, sources and driving factors of organic carbon burial since 1850.
View Article and Find Full Text PDFThe contradiction between social economy and water environment has become increasingly prominent, and the analysis of urban water metabolism system (UWMS) represents a problem-solving approach from the perspective of the entire flow process. However, a comprehensive UWMS model that considers both physical and virtual water flows is currently lacking. This paper presents an innovative application of an ecological network model of the UWMS-integrated metabolic process of physical and virtual water in Xining during the 2002-2018 period.
View Article and Find Full Text PDFTo enhance ecosystem conservation in protected areas, natives' behavior, mainly the use of natural resources or direct human disturbance to ecosystems, must be well intervened and regulated. To explore the determinants and incentives of the conservation behavior of natives, this paper establishes a theoretical behavior model emphasizing livelihood assets and conservation policy impacts, and specifies it with structural equation modeling. The protected areas of Chishui county in southwest China and the Three-River-Source National Park in the Qinghai-Tibet Plateau were selected for empirical analyses based on household surveys.
View Article and Find Full Text PDFNitrogen deposition in lake sediment is an important factor reflecting the evolution of lake environments. Over the past 150-200 years, lakes in China have been affected by natural factors and anthropogenic factors, and nitrogen deposition has increased. As a result, it is critical to reconstruct the spatiotemporal variation trend of nitrogen deposition and analyse the nitrogen source and driving factors.
View Article and Find Full Text PDFFSHD is characterized by the misexpression of DUX4 in skeletal muscle. Although DUX4 upregulation is thought to be the pathogenic cause of FSHD, DUX4 is lowly expressed in patient samples, and analysis of the consequences of DUX4 expression has largely relied on artificial overexpression. To better understand the native expression profile of DUX4 and its targets, we performed bulk RNA-seq on a 6-day differentiation time-course in primary FSHD2 patient myoblasts.
View Article and Find Full Text PDFOverlap between wildlife living spaces and human activity spaces represents one of the main causes of human-wildlife conflict. It is therefore necessary to identify and adjust the spatial distribution of conflicts because climate change will modify the ranges and locations of species. The MaxEnt model was used to simulate the distribution of wildlife living spaces under current and future climatic conditions (RCP4.
View Article and Find Full Text PDFBackground: Increasing reports have confirmed that microRNAs play an important role in breast cancer progression, particularly in triple-negative breast cancer (TNBC). The aim of our study was to investigate the role of miR-33a in TNBC progression.
Methods: PCR assays were performed to detect miR-33a and EZH2 expression in TNBC tissues, adjacent nontumor tissues and cell lines.
Purpose: To investigate the predictive capability of clinical parameters for long-term chemotherapy benefits among stage IIIB-IV non-squamous non-small cell lung cancer (NSCLC) patients without sensitive mutations.
Patients And Methods: We investigated the clinical features of 206 stage IIIB-IV non-squamous NSCLC patients without sensitive mutations and assessed their predictive value for disease control rate (DCR) at 6 and 12 months post-treatment.
Results: Seventy-two patients received docetaxel and platinum-based chemotherapy while 134 received pemetrexed and platinum-based chemotherapy.