Characterization of chitosan-coated PLGA nanoemulsion loaded with cepharanthine and inhibitory effect on Staphylococcus aureus pneumonia of mice.

Staphylococcus aureus (S. aureus), particularly methicillin-resistant strains (MRSA), poses a significant threat to global public health due to its resistance to conventional antibiotics. The urgent need for alternative treatments has highlighted cepharanthine (CEP), a bisbenzylisoquinoline alkaloid, known for its antiviral, antibacterial, and anti-inflammatory properties.

Comparing adsorptive blood purification modalities for sepsis patients: A systematic review and network meta-analysis.

Purpose: Hemoadsorption is a promising therapeutic modality for sepsis, however, the most effective approach is unknown. This meta-analysis aimed to compare the efficacy of different adsorptive blood purification (ABP) modalities in patients with sepsis.

Materials And Methods: Randomized controlled trials (RCTs) investigating the clinical efficacy of ABP modalities in patients with sepsis were retrieved from English databases from inception up to October 14, 2024.

Resistance to Striga parasitism through reduction of strigolactone exudation.

Parasitism with Striga poses a major threat to global food production. Striga germination and growth rely on strigolactones (SLs) exuded by crop roots under phosphate (Pi)-deficient conditions, although the mechanism of this host-parasite interaction remains elusive. In this study, transcriptomic and functional analyses of sorghum treated with Pi deficiency or the SL GR24 identify two ABC transporter G (ABCG) transporters of SL, Sorghum biocolor strigolactones transporter 1 (SbSLT1) and SbSLT2.

Ga-FAPI Small Animal PET/CT in Rats with Peritoneal Fibrosis and the Therapeutic Effect of Sodium Butyrate.

Peritoneal fibrosis (PF) is a common complication in peritoneal dialysis patients with end-stage renal disease. This study established a rat model of PF, used Ga-FAPI PET/CT imaging to visualize PF, and evaluated the therapeutic effects and mechanism of action of sodium butyrate. The rat model of PF ( = 20) was induced by hyperglycemic peritoneal dialysate combined with lipopolysaccharide, the control group ( = 20) was given the same amount of normal saline, and the intervention group ( = 20) was given sodium butyrate by intraperitoneal injection.

Alternating inverse modulation of xylem K/NO loading by HY5 and PIF facilitates diurnal regulation of root-to-shoot water and nutrient transport.

Diurnal light-dark cycles regulate nutrient uptake and transport; however, the underlying molecular mechanisms remain largely unknown. Transcription factor MYB59 and ion transporter NPF7.3 participate in root-to-shoot K/NO translocation in Arabidopsis.

Dynamic history of the Central Plain and Haidai region inferred from Late Neolithic to Iron Age ancient human genomes.

The peopling history of the Yellow River basin (YR) remains largely unexplored due to the limited number of ancient genomes. Our study sheds light on the dynamic demographic history of the YR by co-analyzing previously published genomes and 31 newly generated Late Neolithic to Iron Age genomes from Shandong in the lower YR and the Central Plain in the middle YR. Our analysis reveals the population structure in Shandong and the Central Plain in the Late Neolithic Longshan cultural period.

A Comparison of the Diagnostic Value of Multiorgan Point-of-care Ultrasound between High-risk and Medium-to-low-risk Pulmonary Embolism Cases.

Objective: This study aimed to explore the diagnostic value of multiorgan (heart, lungs, blood vessels) point-of-care ultrasound (PoCUS) in patients with high-risk and medium-to-low-risk pulmonary embolism (PE).

Methods: Clinical data of 92 patients with suspected PE, admitted to Hangzhou TCM Hospital affiliated with Zhejiang Chinese Medical University from July 2021 to June 2023, were retrospectively analyzed. According to hemodynamic status, patients were divided into the high-risk (n=28) and the medium-to-low-risk groups (n=64).

FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1.

Glioblastoma (GBM) is the most malignant type of glioma with a very poor prognosis. N6-methyladenosine (m6A) is well-documented to be involved in GBM progression, and FTO is a demethylase. GSTO1 is also associated with tumor progression.

Iron Oxide Nanoparticle-Based T Contrast Agents for Magnetic Resonance Imaging: A Review.

This review highlights recent progress in utilizing iron oxide nanoparticles (IONPs) as a safer alternative to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI). It consolidates findings from multiple studies, discussing current T contrast agents (CAs), the synthesis techniques for IONPs, the theoretical principles for designing IONP-based MRI CAs, and the key factors that impact their T contrast efficacy, such as nanoparticle size, morphology, surface modifications, valence states, and oxygen vacancies. Furthermore, we summarize current strategies to achieve IONP-based responsive CAs, including self-assembly/disassembly and distance adjustment.

CPK28-mediated phosphorylation enhances nitrate transport activity of NRT2.1 during nitrogen deprivation.

Nitrate (NO ) serves as the primary inorganic nitrogen source assimilated by most terrestrial plants. The acquisition of nitrate from the soil is facilitated by NITRATE TRANSPORTERS (NRTs), with NRT2.1 being the key high-affinity nitrate transporter.

Evaluation of Severe ultrasound and gene diagnosis in cardiac index and shock patient index of shock patients.

Background: The kidney is the most vulnerable organ in severe patients. In severe cases, the fatality rate of acute kidney damage is as high as 30% ∼ 60%. Severe ultrasound is a non-invasive method to evaluate renal blood flow.

The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis.

Background: Renal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with a poor prognosis and high mortality. Angiopoietin-like 4 (ANGPTL4) is known to be associated with fibrosis in various organs, but its impact on the RIF process remains unclear. This study aimed to elucidate the role and underlying mechanisms of ANGPTL4 in the progression of RIF.

Research on Improved Crystallization Properties and Underlying Mechanism of the SbTe Phase-Change Thin Film by Inserting SnSb Layers.

As a non-volatile semiconductor memory technology, phase-change memory has a wide range of application prospects as a result of the excellent comprehensive performance. In this paper, multilayer thin films based on SbTe material were designed and prepared by inserting the SnSb layer. The thermal and electrical properties of superlattice-like SbTe/SnSb phase-change films can be adjusted by controlling the thickness ratio of SbTe/SnSb.

Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke.

Neuronal ferroptosis plays a key role in neurologic deficits post intracerebral hemorrhage (ICH). However, the endogenous regulation of rescuing ferroptotic neurons is largely unexplored. Here, we analyzed the integrated alteration of metabolomic landscape after ICH using LC-MS and MALDI-TOF/TOF MS, and demonstrated that aconitate decarboxylase 1 (Irg1) and its product itaconate, a derivative of the tricarboxylic acid cycle, were protectively upregulated.

Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis.

Background: Macrophages are innate immune cells whose phagocytosis function is critical to the prognosis of stroke and peritonitis. cis-aconitic decarboxylase immune-responsive gene 1 (Irg1) and its metabolic product itaconate inhibit bacterial infection, intracellular viral replication, and inflammation in macrophages. Here we explore whether itaconate regulates phagocytosis.

Retraction Notice to: miRNA-129/FBW7/NF-κB, a Novel Regulatory Pathway in Inflammatory Bowel Disease.

[This retracts the article DOI: 10.1016/j.omtn.

Liver inflammation activity in patients with autoimmune hepatitis with normal alanine aminotransferase and immunoglobulin G levels.

Background And Aims: Normal serum transaminases and immunoglobulin G (IgG) levels are surrogate markers for hepatic histologic disease activity in autoimmune hepatitis (AIH). This study aimed to evaluate liver inflammation in patients with AIH with normal serum alanine aminotransferase (ALT) and IgG levels.

Methods: Two hundred and five AIH patients who underwent liver biopsy in four medical centers were included.

Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta-analysis.

Aims: Systemic lupus erythematosus (SLE) is an autoimmune disease with a high prevalence worldwide. This study aimed to examine the correlation between serum bilirubin levels and SLE.

Methods: The Cochrane library, Embase, PubMed, and China National Knowledge Infrastructure (CNKI) databases were examined and assessed until March 2023.

Algorithm Design and Convergence Analysis for Coexistence of Cognitive Radio Networks in Unlicensed Spectrum.

This paper focuses on achieving the low-cost coexistence of the networks in an unlicensed spectrum by making them operate on non-overlapping channels. For achieving this goal, we first give a universal convergence analysis framework for the unlicensed spectrum allocation algorithm. Then, a one-timescale iteration-adjustable unlicensed spectrum allocation algorithm is developed, where the step size and timescale parameter can be jointly adjusted based on the system performance requirement and signal overhead concern.

Ultrasound-propelled liposome circumvention and siRNA silencing reverse BRAF mutation-arised cancer resistance to trametinib.

BRAF-V600E mutation is regarded as the source of lung cancer resistance to trametinib (Tr), and no solution available for completely addressing this intractable resistance has emerged yet. Herein, the combination of ultrasonic (US) propelled folic acid (FA)-modified liposomes strategy and BRAF-driven gene silencing program is proposed to effectively reverse Tr's resistance to lung cancer. Meanwhile, the prepared cationic nanoliposomes can assist Tr drug and BRAF siRNA to escape lysosome disposal, thereby avoiding Tr drug pumping out or siRNA degradation.

IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke.

Accumulation of reactive oxygen species (ROS), especially on lipids, induces massive cell death in neurons and oligodendrocyte progenitor cells (OPCs) and causes severe neurologic deficits post stroke. While small compounds, such as deferoxamine, lipostatin-1, and ferrostatin-1, have been shown to be effective in reducing lipid ROS, the mechanisms by which endogenously protective molecules act against lipid ROS accumulation and subsequent cell death are still unclear, especially in OPCs, which are critical for maintaining white matter integrity and improving long-term outcomes after stroke. Here, using mouse primary OPC cultures, we demonstrate that interleukin-10 (IL-10), a cytokine playing roles in reducing neuroinflammation and promoting hematoma clearance, significantly reduced hemorrhage-induced lipid ROS accumulation and subsequent ferroptosis in OPCs.

Influence of samarium modification on the phase-change performance and phase structure of tin antimonide.

This work presents the optimization of the crystallization behavior and reliability of SnSbthin films by doping Sm element. The phase transition behaviors induced by thermal were investigated byresistance measurement. With the addition of Sm element, SnSbfilm exhibits the superior crystallization temperature (232 °C) and data conservation (172.

Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro.

Influenza H7N9 virus causes human infections with about 40% case fatality rate. The severe cases usually present with pneumonia; however, some present with central nervous system complications. Pneumonia syndrome is attributed to the cytokine storm after infection with H7N9, but the pathogenic mechanism of central nervous system complications has not been clarified.