Complications and patient-reported outcomes after radiotherapy in breast cancer patients undergoing implant-based breast reconstruction: a retrospective study from a large Chinese breast disease center.

Background: Postmastectomy radiation therapy (PMRT) can influence the outcome of implant-based breast reconstruction (IBBR). This study aims to investigate the complications and patient-reported outcomes (PROs) following PMRT between direct-to-implant (DTI) and tissue expander-to-implant (TEI) reconstruction.

Methods: The retrospective study included breast cancer patients undergoing IBBR and PMRT.

Synthesis and Application of Hybrid Aluminum Dialkylphosphinates as Highly Efficient Flame Retardants for Polyamides.

Hybrid aluminum dialkylphosphinates were synthesized from mixed diethyl-, ethylisobutyl-, and diisobutylphosphinates and Al in water. The XRD, DSC, and TGA results of these Al phosphinates established that phosphinate ligands are randomly distributed in the species. The thermal and thermoxidative stabilities of the hybrid phosphinates were easily adjustable by varying the ratio of phosphinate ligands, a desirable feature for efficient flame retardants.

Erratum: [Corrigendum] Mesenchymal stem cells expressing interleukin‑18 suppress breast cancer cells .

[This corrects the article DOI: 10.3892/etm.2015.

Erratum: [Corrigendum] Mesenchymal stem cells expressing interleukin‑18 inhibit breast cancer in a mouse model.

[This corrects the article DOI: 10.3892/ol.2018.

Hormone receptor-positive, HER2-negative, metastatic breast cancer responded well to abemaciclib and exemestane after palbociclib and fulvestrant failure: A case report and literature review.

There is uncertainty regarding the usefulness of CDK4/6-inhibitor-based therapy for hormone receptor positive (HR+), human epidermal grow factor receptor 2 negative (HER2-), metastatic breast cancer (MBC), when CDK4/6 inhibitor treatment had previously failed. Furthermore, a biomarker for abemaciclib resistance has not been identified. Herein, we reported outcomes for an HR+/HER2- MBC patient diagnosed with multiple myeloma and treated with abemaciclib and exemestane, who had cancer progression after treatment with palbociclib and fulvestrant.

Prognostic value and immunological role of Kruppel-like transcription factor 9 gene in pan-carcinoma.

Objective: To investigate the correlation between the expression of Kruppel-like transcription factor 9 (KLF9) and the prognostic value of tumors as well as its relationship with tumor immune invasion.

Methods: A series of bioinformatics methods were used to analyze the relationship between KLF9 and tumor prognosis, tumor mutation burden, microsatellite instability (MSI), and immune cell infiltration in multiple carcinomas.

Results: In multiple tumor tissues, the expression of KLF9 was lower compared with paracancerous tissues.

Interfacial silicon‑nitrogen aerogel raise flame retardancy of bamboo fiber reinforced polylactic acid composites.

A triazine derivative containing nitrogen and silicon (SiN) was synthesized and the SiN hybrid aerogel was covered on the surface of bamboo fiber (BF). The modified BF was identified as MBF. The MBF and ammonium polyphosphate (APP) were used to regulate the flame retardancy and mechanical properties of polylactic acid (PLA).

The role of DDX46 in breast cancer proliferation and invasiveness: A potential therapeutic target.

DDX46, a member of DEAD-box (DDX) proteins, is associated with various cancers, while its involvement in the pathogenesis of breast cancer hasn't been reported so far. The study demonstrated the overexpression of DDX46 in human breast cancer cells and tissue samples, and correlated with high histological grade and lymph node metastasis. Downregulation of DDX46 in the breast cancer cell lines inhibited their proliferation and invasiveness in vitro.

Using Cellulose--Poly(L-lactide) Copolymers as Effective Compatibilizers for the Preparation of Cellulose/Poly(L-lactide) Composites with Enhanced Interfacial Compatibility.

Cellulose--poly(L-lactide) (C--PLLA) copolymers synthesized in a CO-switchable solvent are proposed for use as effective compatibilizers for the preparation of cellulose-PLLA composites with enhanced interfacial compatibility. The effect of the molar substitution () of the grafted PLLA side chain in the C--PLLA copolymer and the feeding amount of this copolymer on the mechanical and thermal properties and hydrophilicity of the composites was investigated. The composites had a largely increased impact strength with the incorporation of the compatibilizer.

Clinical Characteristics and Death Risk Factors of Severe Sepsis in Children.

Sepsis is a systemic inflammatory response syndrome caused by viral infection. The circulatory dysfunction caused by sepsis is also called septic shock or septic shock. The main characteristics are rapid onset, rapid changes, and involvement.

Augmentation of antitumor function of tumor-infiltrating lymphocytes against triple-negative breast cancer by PD-1 blockade.

T-cell-based immunotherapy and immune checkpoint blockade have been successfully used to treat several human solid cancers. The present study attempted to investigate the feasibility and efficacy of the antitumor effect of adoptive cell therapy along with programmed cell death protein 1 (PD-1) inhibitor on triple-negative breast cancer (TNBC). Tumor infiltration lymphocytes (TILs) from TNBC mouse tumor tissues were isolated and expanded, and TILs for adoptive cell therapy (TILs-ACT) were applied in combination with a PD-1 inhibitor to the TNBC mouse model.

Assessing the environmental impact of China's tourism activities: a tourism heat footprint method.

Numerous research studies have examined carbon emissions generated from tourism activities. However, the environmental impact of anthropogenic heat release has not attracted researchers' attention. We apply the tourism heat footprint method to assess the environmental impact of China's tourism activities.

An Extremely Efficient Silylated Benzensulfonate Flame Retardant for Polycarbonate.

An extremely efficient flame retardant with low water solubility has been developed for bisphenol-A based polycarbonate. Potassium trimethylsilylbenzenesulfonate (KTSS) combining trimethylsilyl and sulfonate groups in its molecule is 7 times less water soluble and 5 times more effective in flame retardancy than potassium benzenesulfonylbenzenesulfonate (KSS), the commercial workhorse for polycarbonate (PC). At a loading of 0.

Circular RNA 000554 represses epithelial-mesenchymal transition in breast cancer by regulating microRNA-182/ZFP36 axis.

Increasing evidence indicates that circular RNAs (circRNAs) play a crucial role in regulating microRNAs (miRs) and mRNAs during breast cancer (BC) progression. Based on the in silico analysis of circRNA/miR/mRNA in BC, we aim to define an important role of circRNA_000554 in BC in relation to miR-182 and zinc finger protein 36 (ZFP36). Low expression of circRNA_000554 and ZFP36, and high miR-182 expression were determined in the clinical BC tissues.

APOBEC3B expression and its prognostic potential in breast cancer.

Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) mRNA expression is associated with the poor prognosis of estrogen receptor positive (ER+) breast cancer. However, the clinical relevance of APOBEC3B protein expression in patients with breast cancer remains unclear. The present study evaluated the association of APOBEC3B protein expression with clinicopathological features, as well as survival outcomes of patients with breast cancer.

Base Promoted Intumescence of Phenols.

The intumescent process of sodium (substituted) phenolates has been studied. The generation of hydrogen radical via a homolytic cleavage of the Ar-H bond and the subsequent hydroarylation of phenolates to cyclohexadienes along with cyclization and elimination reactions of cyclohexadienes are critical steps in the base promoted intumescence of phenols. The substituents show great influence on the intumescence of phenolates.

On the Origin of Alkali-Catalyzed Aromatization of Phenols.

To gain an insight of the chemistry in the alkali-promoted aromatization of oxygen-containing heavily aromatic polymers or biomass; thermal degradations of sodium phenolates with different substituents have been investigated. The -ONa group strongly destabilizes the phenolates. The thermal stability of phenolates is largely in parallel with bond strengths of Ar substituents.

PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation.

Background: Interleukin-6 (IL-6) has been demonstrated to be a critical factor for breast cancer malignancy. However, the molecular mechanisms by which IL-6 induce breast cancer cells epithelial-mesenchymal-transition (EMT) and stemness remain elusive.

Methods: Breast cancer cell lines T47D and MCF7 were exposed to IL-6, the expression of PIM1 was examined by quantitative real-time PCR (qRT-PCR) and western blot.

p53-independent role of MYC mutant T58A in the proliferation and apoptosis of breast cancer cells.

Myc proto-oncogene (MYC) is an oncoprotein that promotes proliferation and apoptosis. MYC mutations frequently disrupt the apoptotic processes during tumorigenesis. In the present study, the effects of the MYC point mutation T58A on the progression of a cellular tumor antigen p53 (p53) human breast cancer cell line was analyzed, and the mechanism of p53-independent MYC-induced apoptosis was investigated.

Mesenchymal stem cells expressing interleukin-18 inhibit breast cancer in a mouse model.

Development of an improved breast cancer therapy has been an elusive goal of cancer gene therapy for a long period of time. Human mesenchymal stem cells derived from umbilical cord (hUMSCs) genetically modified with the interleukin (IL)-18 gene (hUMSCs/IL-18) were previously demonstrated to be able to suppress the proliferation, migration and invasion of breast cancer cells . In the present study, the effect of hUMSCs/IL-18 on breast cancer in a mouse model was investigated.

MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression.

MicroRNAs (miRs), acting as tumor suppressor or oncogenes genes, play a critical role in controlling tumor invasion, metastasis and survival via regulating a variety of targets. MiR-148a has been observed low expressed in several types of human cancers, and overexpression of miR-148a inhibits tumorigenesis. However, the molecular mechanisms of miR-148a-mediated these effects are largely elusive.

[Protective effect of ulinastatin on cerebral tissue in rats with lethal scald injury].

Objective: To explore the protective effects of ulinastatin on cerebral tissue in rats following lethal burn injury and its relationship with the expression of protective protein.

Methods: A total of 40 male Sprague-Dawley rats were randomly divided into scald and ulinastatin groups (n = 20 each). Both groups were subjected to 50% total body surface area third-degree burns.

Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells .

Breast cancer is the most common malignancy among females throughout the world. Current treatments have unsatisfactory outcomes due to the dispersed nature of certain types of the disease. The development of a more effective therapy for breast cancer has long been one of the most elusive goals of cancer gene therapy.

Lentivirus-mediated inhibition of USP39 suppresses the growth of breast cancer cells in vitro.

Worldwide, breast cancer is the most frequently diagnosed life-threatening cancer in women and is the leading cause of cancer-related mortality among women. It is extremely rare but highly lethal in men. The deubiquitinating enzyme USP39 plays important roles in mRNA processing, and our previous data showed that high levels of USP39 are selectively present in different types of human breast tumor cells.