Hexamethylene amiloride induces lysosome-mediated cell death in multiple myeloma through transcription factor E3.

Multiple myeloma (MM) is the second common hematological malignancy characterized by the abnormal proliferation of plasma cells. Although advances in the past decades have led to improved outcomes and longer survival, MM remains largely incurable. New targets and targeted therapy may help to achieve better outcomes.

Cxcl10 and Cxcr3 regulate self-renewal and differentiation of hematopoietic stem cells.

Background: The function of hematopoietic stem cells (HSC) is regulated by HSC internal signaling pathways and their microenvironment. Chemokines and chemokine ligands play important roles in the regulation of HSC function. Yet, their functions in HSC are not fully understood.

Antibacterial Effects of Magnetically-Controlled Ag/Fe₃O₄ Nanoparticles.

This paper presents the use of a magnetic manipulation device to remotely control the movement of Ag/Fe₃O₄ nanoparticles (NPs) for enhancing the antibacterial effect of Ag particles in aqueous suspensions containing (). The Ag/Fe₃O₄ magnetic NPs were prepared by co-precipitation method where the Ag particles are simultaneously synthesized with the Fe₃O₄ particles to form Ag and Fe₃O₄ nanocomposite materials. The manipulation system utilized a homogeneous rotating magnetic field to carry out magnetic stirring of NPs in the petri dishes containing bacterial suspensions.