Publications by authors named "Weiguo Lv"
: This study aims to assess the immediate risk of cervical intraepithelial neoplasia grade (CIN)3+ lesions in women with abnormal cervical glandular cytology. : A total of 403 women with abnormal cervical glandular cytology who underwent simultaneous HPV genotyping and cervical biopsy at the Zhejiang University School of Medicine Women's Hospital, China, between 2016 and 2020, were included in this study. The probability of CIN3+ lesions among women in each group was further analyzed.
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- Mismatch repair-deficient (dMMR) endometrial cancer is associated with poor outcomes and limited treatment options, particularly for high-risk patients after surgery.
- In a phase III clinical trial, patients with dMMR tumors were treated with pembrolizumab plus chemotherapy, showing improved disease-free survival (DFS) rates compared to those who received placebo.
- The interim analysis revealed a significant DFS benefit for pembrolizumab, with a two-year DFS rate of 92.4% versus 80.2% for the placebo group, indicating its potential effectiveness in high-risk dMMR endometrial cancer.
Advancing clinical-basic-clinical research: exploring novel immunotargets for ovarian cancer.
Signal Transduct Target Ther
September 2024
Background: The prospective phase III multi-centre L-MOCA trial (NCT03534453) has demonstrated the encouraging efficacy and manageable safety profile of olaparib maintenance therapy in the Asian (mainly Chinese) patients with platinum-sensitive relapsed ovarian cancer (PSROC). In this study, we report the preplanned exploratory biomarker analysis of the L-MOCA trial, which investigated the effects of homologous recombination deficiency (HRD) and programmed cell death ligand 1 (PD-L1) expression on olaparib efficacy.
Methods: HRD status was determined using the ACTHRD assay, an enrichment-based targeted next-generation sequencing assay.
Context.—: Molecular stratification of endometrial carcinoma provides more accurate prognostic information than traditional clinicopathologic features. However, because next-generation sequencing is typically recommended for polymerase tifilon (POLE) mutation detection, the practical application of a test based on molecular stratification is limited in the clinical setting.
View Article and Find Full Text PDFBackground: Although interleukin-2 (IL-2) has long been associated with cancer development, its roles in the development of cervical cancer remains unclear. Few studies examined the associations between IL-2 and high-risk human papillomavirus (HPV) with risk of cervical intraepithelial neoplasia (CIN).
Objective: We aimed to assess the association of IL-2 and high-risk HPV infection with risk of CIN as well as their interactions on the risk of CIN.
Article Synopsis
- Platelets can be influenced by cancer through a process called education, leading to a specific transcriptional profile that can aid in cancer detection, particularly for ovarian cancer.
- A study involving 761 patients with confirmed adnexal masses and 167 healthy controls across multiple countries showed that tumor-educated platelets (TEPs) had a high diagnostic accuracy, with AUCs (area under the curve) ranging from 0.887 to 0.923 in validation cohorts.
- Combining TEPs with the CA125 biomarker further improved detection accuracy, and TEPs showed potential across diverse populations and cancer stages, but further extensive studies are necessary before they can be widely used in clinical settings.
Background: The use of molecular categorisation is shifting paradigm towards the use of molecular information to refine risk stratification in endometrial cancer (EC). To date, evidence to support molecular-guided therapies is limited to retrospective studies and secondary molecular analyses of patients receiving standard treatment. The PROBEAT study is the first randomized phase III trial to evaluate tailored adjuvant treatment based on WHO-endorsed molecular classification in Chinese EC patients.
View Article and Find Full Text PDFBackground: Preoperative neoadjuvant chemotherapy (NACT) has been widely used in developing countries for the treatment of patients with International Federation of Gynecology and Obstetrics (FIGO) stages IB3 and IIA2 cervical cancer. However, the effectiveness of NACT and treatment options for NACT-insensitive patients have been concerning. This study will assess prognostic differences between NACT and primary surgery treatment (PST), determine factors associated with prognosis, and explore better adjuvant treatment modalities for NACT-insensitive patients.
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- - The study aimed to compare the safety of cervical conization (CC) alone versus hysterectomy in patients with adenocarcinoma in situ (AIS) of the cervix, using data from Women's Hospital of Zhejiang University from 2007-2021.
- - Results showed a significantly higher prevalence of residual disease in patients with positive margins (50.6%) compared to negative margins (2.3%), while recurrence rates were similar between both treatment groups: 0.7% for CC alone and 1.3% for hysterectomy.
- - The conclusion highlighted that CC is a safe and effective treatment for AIS if the surgical margins are negative, suggesting it could be preferred over hysterectomy for specific cases.
Human papillomaviruses (HPV), mainly HPV16 and HPV18, of high-risk classification are involved in cervical cancer carcinogenesis and progression. Octamer-binding transcription factor 4 (OCT4) is a key transcription factor that is increased in various cancer types. Cervical cancer patients with higher levels of OCT4 had worse survival rates.
View Article and Find Full Text PDFBackground: Although folate status is associated with cervical carcinogenesis, it is not clear whether folate deficiency is associated with risk of cervical intraepithelial neoplasia (CIN) progression and infection with high-risk human-papillomavirus (hrHPV).
Objectives: To evaluate the associations of RBC and serum folate concentrations with prevalence of CIN grades and hrHPV infection, their interactions with prevalence of CIN grades, and RBC folate with the risk of CIN1 progressing to CIN2.
Methods: Using data from the Shanxi CIN cohort of 2304 female Chinese adults, we used logistic-regression model to estimate ORs and prevalence ratios (PRs) of RBC and serum folate concentrations with prevalence of CIN grades and hrHPV infection.
Article Synopsis
- This study examined the effectiveness of pirfenidone (PFD) in treating pulmonary fibrosis in patients who suffered from acute paraquat poisoning, comparing those treated with PFD to those who were not.
- Results showed that the PFD group had a significantly higher effective treatment rate and improved pulmonary function, as indicated by various medical metrics, compared to the NO-PFD group.
- The study concluded that PFD is a safe and effective option for enhancing treatment outcomes in these patients, improving both lung function and survival rates without substantial liver or kidney damage.
Article Synopsis
- Exosomal microRNA (miRNA) plays a crucial role in tumor-related blood vessel formation (angiogenesis), which is important in various cancers, but treatments targeting this process have shown limited effectiveness in ovarian cancer.
- The study involved isolating exosomes, sequencing their miRNA, and creating a cell line that overexpresses miR-92b-3p to investigate its effects on angiogenesis using in vitro and in vivo models, including zebrafish and mice.
- Results indicated that ovarian cancer exosomes promote angiogenesis due to lower levels of miR-92b-3p, which targets SOX4, and engineered exosomes with higher miR-92b-3p content exhibited stronger anti-angi
Article Synopsis
- The study focused on the effectiveness of high-risk HPV genotyping in managing women with atypical Pap results (ASC-US) in rural China, involving 40,000 participants.
- Among women with ASC-US, the rates of more serious cervical conditions (CIN2+ and CIN3+) were found to be 7.28% and 1.75%, respectively, with HPV16 being the most common genotype detected.
- Genotyping for specific HPV types significantly improved screening efficiency, reducing unnecessary colposcopy referrals without compromising sensitivity in detecting severe lesions.
Earlier literature suggests that ovarian preservation in young premenopausal clinical stage I endometrioid endometrial carcinoma patients does not negatively impact prognosis. The main purpose of this study was to clarify the incidence of ovarian malignant involvement in this group and further identify potential preoperative predictive factors of ovarian malignant involvement. A total of 511 premenopausal (age ≤ 50 years) patients were enrolled for the study at Women's Hospital, Zhejiang University School of Medicine, between January 2002 and December 2016.
View Article and Find Full Text PDFPopulation-based studies investigating the association between dietary mineral intake and risk of cervical intraepithelial neoplasia (CIN) or cervical cancer in Chinese women are few. We performed a cross-sectional analysis of screening data obtained from 2,304 women in 2014 within an ongoing cohort study comprising 40,000 women in China. Dietary intake was assessed using a semiquantitative food frequency questionnaire.
View Article and Find Full Text PDFBackground: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China.
Methods: Data on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included.
Purpose: There is currently a lack of research on preoperative prognostic analysis of early-stage cervical adenocarcinoma (ADC). The purpose of our study was to clarify whether preoperative serum tumor-marker levels were of prognostic value in early-stage ADC.
Patients And Methods: We performed a retrospective study of patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA1-IIA1 and pathology-proven invasive ADC.
Article Synopsis
- * Out of the participants, 6.76% had abnormal cytology results, with 1.96% confirmed to have cervical lesions, including a notable number of CIN2+ cases.
- * Findings indicated varying screening results by region and age, highlighting the 60-65 age group as having the highest cytologic abnormalities, which provides valuable insights for shaping a national cervical cancer screening strategy in China.
Purpose: To report a novel method to achieve hemostasis and to evaluate efficacy and safety of controlling hemorrhage from the lower uterine segment (LUS) during cesarean section for placenta previa and accrete compared with conventional surgery.
Methods: From January 2017 to June 2019, there were 65 cases of pernicious placenta previa admitted in our obstetric department. They all had performed selective cesarean sections.
Purpose: We aim to identify the methylation status of delta-like 1 (DLK1) in the placenta and the correlation between DLK1 methylation and maternal serum glucose level and fetal birth weight.
Methods: We analyzed the gene expression of DLK1 gene in both maternal and fetal sides of the placenta in a GDM group ( = 15) and a control group ( = 15) using real-time polymerase chain reaction. With MethylTargetTM technique, we detected the methylation status of DLK1 promotor in the placenta.
Background: The systematic evaluation of the diagnostic value of hysteroscopy and transvaginal ultrasonography for endometrial hyperplasia.
Methods: A systematic search was performed using China Knowledge Network Database, Wanfang Chinese Database, China Biomedical Literature Database, China Science and Technology Journal Database, PubMed, Medline, The Cochrane Library, and web of science from their dates of inception to December 31, 2017, hysteroscopy and transvaginal ultrasonography were used for the diagnosis of endometrial lesions in those studies. Two researchers screened the literature, extracted data, and evaluated the methodological quality of the included studies independently based on the inclusion criteria.
Type 2 Cesarean Scar Pregnancy Successfully Treated via Hysteroscopy-Assisted Laparoscopy.
J Minim Invasive Gynecol
May 2020
Study Objective: To evaluate the efficacy of hysteroscopy-assisted laparoscopy as a treatment strategy for type 2 cesarean scar pregnancy at gestational age >8 weeks.
Design: Retrospective case series (Canadian Task Force classification II-3).
Setting: A tertiary hospital.
Background: Although folate deficiency has long been implicated in cancer development, uncertainties remain concerning its role in cervical cancer prevention. In particular, the interaction between human papillomavirus (HPV) and folate in the risk of cervical intraepithelial neoplasia (CIN) has been little studied.
Objective: The goal of this study was to evaluate the dose-response association of serum folate with the risk of CIN, and the potential for HPV to modify the risk of CIN.