Publications by authors named "Weiguang Shen"

Objective: The objective of this study is to devise an indicator system to assess the quality of nursing care in the context of interventional therapy for intracranial aneurysms (IA) in China. This will furnish a standardized and quantitative framework for the monitoring and assessment of nursing quality within the IA interventional therapeutic field.

Methods: The indicators and their associated weights within the evaluation system for nursing quality in interventional therapy for IA were determined based on the theoretical framework of the three-dimensional quality model, specifically the "structure-process-outcome" paradigm.

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Tamoxifen (TAM) is a classical anti-estrogenic drug that antagonizes estrogen by competitively binding to estrogen receptor α (ERα). However, drug resistance to TAM remains a significant challenge in breast cancer treatment. In this study, we aimed to design an actively targeted drug delivery system to enhance the proliferation inhibitory effects of TAM on ER positive breast cancer cells.

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Article Synopsis
  • Adriamycin (ADM) is a chemotherapy drug for gastric cancer, but many patients experience chemoresistance, prompting this study to focus on the impact of long non-coding RNA (lncRNA) H19 on this issue.
  • Researchers found that H19 was overexpressed in gastric cancer tissues; reducing H19 led to increased sensitivity of cancer cells to ADM and enhanced cell death.
  • The study suggests that H19 influences chemoresistance through its interaction with microRNA-152 (miR-152) and transcription factor 4 (TCF4), providing insight into potential therapeutic strategies for overcoming chemoresistance in gastric cancer.
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