Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?

Unlabelled: Although cerebral amyloid deposition may precede cognitive impairment by decades, the relationship between amyloid deposition and longitudinal change in neuronal function has not, to our knowledge, been studied. The aim of this article was to determine whether individuals without dementia with high and low amyloid burden show different patterns of longitudinal regional cerebral blood flow (rCBF) changes in the years preceding measurement of amyloid deposition.

Methods: Twenty-eight participants without dementia (mean age+/-SD, 82.