Publications by authors named "Weigang Pan"

Background: Geriatric hip fractures pose a significant health burden, and inflammation may play a role in the short- and long-term prognosis. However, the prognostic significance of hematologic inflammatory markers in geriatric patients with fractures is not understood. The aim of this systematic review and meta-analysis was to assess the prognostic implications of systemic inflammatory markers on the long-term mortality of older patients with hip fractures.

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  • Adolescents in economically disadvantaged rural areas are particularly vulnerable to social anxiety, highlighting the need to identify effective prevention and intervention strategies to support their mental health and social skills.
  • The study examines the roles of perceived social support, core self-evaluation, and shyness in influencing social anxiety among 626 rural secondary school students using structured scales and mediation analysis.
  • Findings reveal that higher perceived social support and core self-evaluation reduce social anxiety, while shyness increases it, with the relationship being influenced by gender differences.
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Background: Although intermittent theta burst stimulation (iTBS) has shown effectiveness in addressing working memory (WM) deficits in individuals with schizophrenia (SZ), the current body of evidence is limited and the specific mechanisms involved remain unclear. Therefore, this pilot fMRI study aimed to examine the efficacy of parietal iTBS in ameliorating WM impairments and explore its influence on the resting-state effective connectivity within the frontoparietal network in patients with SZ.

Method: A total of 48 patients diagnosed with SZ were randomly assigned to an active or sham iTBS group and underwent 20 sessions of active or sham iTBS over 4 weeks.

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  • A study explored the variability of EEG signals evoked by transcranial magnetic stimulation (TMS) in patients with depressive disorder (DE) compared to healthy controls (HC).
  • Researchers analyzed TMS-EEG data from 34 DE patients and 36 HC, finding that DE patients had lower variability in the Gamma band and higher variability in the Delta band compared to HC.
  • The findings indicate that the new method used to assess trial-by-trial variability (TTV) in TMS-EEG is more sensitive than traditional methods, providing important insights into the neurophysiological differences in DE.
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Background: Executive function deficits (EFD) in late-life depression (LLD) has been reported to be associated with antidepressant treatment resistance, increased disability, and poor quality of life. However, the underlying neutral mechanisms of EFD in patients with the first episode of LLD remains unclear.

Methods: A total of 27 patients with first-episode, drug-naive LLD and 27 non-depressed controls (NC) were recruited for the present research.

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Background: Previous studies have documented thalamic functional connectivity (FC) abnormalities in schizophrenia, typically examining the thalamus as a whole. The specific link between subregional thalamic FC and cognitive deficits in first-episode schizophrenia (FES) remains unexplored.

Methods: Using data from resting-state functional magnetic resonance imaging, we compared whole-brain FC with thalamic subregions between patients and HCs, and analyzed FC changes in drug-naïve patients separately.

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Working memory (WM) deficits are a significant component of neurocognitive impairment in individuals with schizophrenia (SCZ). Two previous meta-analyses, conducted on randomized controlled trials (RCTs), examined the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in addressing WM deficits in individuals diagnosed with SCZ. However, the conclusions drawn from these analyses were inconsistent.

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Background: In the realm of cognitive screening, the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are widely utilized for detecting cognitive deficits in patients with late-life depression (LLD), However, the interindividual variability in neuroimaging biomarkers contributing to individual-specific symptom severity remains poorly understood. In this study, we used a connectome-based predictive model (CPM) approach on resting-state functional magnetic resonance imaging data from patients with LLD to establish individualized prediction models for the MoCA and the MMSE scores.

Methods: We recruited 135 individuals diagnosed with first-episode LLD for this research.

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Background: Mobile phone addiction (MPA) is a prevalent problem among college students, and Chinese college students are a high-risk group for smartphone addiction. MPA has a negative impact on the physical and mental health and academic performance of college students. Studies have explored the influence of many factors on MPA, such as the characteristics of the smartphone itself, the characteristics of the smartphone user, and the environment.

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Objectives: Alzheimer's disease (AD) and late-life depression (LLD) frequently exhibit executive function deficits (EFD) and medial temporal lobe atrophy (MTA) as shared characteristics. The objective of this research was to examine the utility of the Trail Making Test (TMT) and the MTA scale in distinguishing between LLD and AD.

Methods: A study of 100 patients, 50 with AD and 50 with LLD, was conducted using a cross-sectional design.

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Objectives: Cognitive impairment is common and linked to poor outcomes in patients with late-onset depression (LOD). The cognitive effects of repetitive transcranial magnetic stimulation (rTMS) for LOD are not well understood. This study aimed to investigate the effects of rTMS on cognitive function in elderly patients with LOD.

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Self-control is important for maintaining good health, acquiring achievement and happiness, and improving environmental adaptability. Trait self-control can affect the processing of emotional conflict in daily life and is associated with successful emotional regulation. In this study, the task functional magnetic resonance imaging (fMRI) technology was adopted to explore the emotion regulation processing and neural mechanism of individuals with different trait self-control levels.

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D-amino acids may be indicators of late-life depression but separation and quantification of enantiomers which differ only by optical rotation sign remain challenging due to their identical physical and chemical properties. A convenient LC-MS/MS method was developed for the simultaneous measurement of l- and d-amino acids based on the chiral derivatization reagent, N-(5-fluoro-2,4-dinitrophenyl)-L-leucinamide, and conventional octadecylsilane reversed-phase column. Methanol was used as the extraction solvent and a single-step derivatization reaction using volatile triethylamine eliminated the requirement for desalination prior to LC-MS/MS.

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Objectives: To preliminarily explore the functional activity and information integration of the brains under resting state based on graph theory in patients with first-episode, late-life depression (LLD) before and after antidepressant treatment.

Methods: A total of 50 patients with first-episode LLD and 40 non-depressed controls (NCs) were recruited for the present research. Participants underwent the RBANS test, the 17-item Hamilton depression rating scale (HAMD-17) test, and resting-state functional MRI scans (rs-fMRI).

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Objective: The purpose of this study was to investigate the mental health of homosexual adults in China and to explore the effects of perceived social support and self-efficacy on mental health.

Methods: Two hundred and nine homosexuals were recruited to participate in the online survey. The Perceived Social Support Scale, General Self-efficacy Scale, Self-rating Anxiety Scale and Self-rating Depression Scale were completed through a questionnaire website.

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Mobile robot path planning has attracted much attention as a key technology in robotics research. In this paper, a reformative bat algorithm (RBA) for mobile robot path planning is proposed, which is employed as the control mechanism of robots. The Doppler effect is applied to frequency update to ameliorate RBA.

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Objectives: To investigate the altered intrinsic brain activity (IBA) in patients suffering from late-life depression (LLD) using a percent amplitude of fluctuation (PerAF) method.

Methods: In total, fifty patients with LLD and 40 non-depressed controls (NCs) were recruited for the present research. Participants underwent the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) test and resting-state functional MRI (rs-fMRI) scans.

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Unlabelled: The response rate of treatment for late-life depression (LLD) is only 25-60%. The cognitive impairment associated with LLD often affects the effectiveness of antidepressants and may has the potential ability to predict response. This study seeks a biomarker for baseline cognitive function to predict efficacy of antidepressants.

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Childhood is an important period of individual psychological development, and parents' company and parenting styles are highly significant to children's personality cultivation and mental health. With the advancement of China's modernization and urbanization, left-behind children without their parents' company have become a growing concern. Compared with children raised by their parents, left-behind children are more likely to show social maladaptation and mental health problems.

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Reflected appraisals refer to the perceptions of individuals of how they are perceived by others. Numerous studies in cultural psychology have revealed that individuals in the Eastern collectivist culture show an interdependent self-construal, which depends much on the social culture. Hence, the research on reflected appraisals in the Eastern culture can improve the understanding of how the social environment shapes the self-perception of an individual.

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Individuals must constantly adjust their behavior to adapt to the changing environment, and this dynamic adjustment ability has been studied through the conflict adaptation effect (CAE). We explored the resting state brain network underlying individual differences in CAE. The functional connection strength between dorsolateral prefrontal cortex (DLPFC) and bilateral insula or right anterior cingulate cortex (ACC) was negatively correlated with CAE, whereas the connection strength between DLPFC and left inferior parietal lobule was positively correlated with CAE.

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Background: Evidence from previous virus epidemics has shown that infected patients are at risk for developing psychiatric and mental health disorders, such as depression, anxiety, and insomnia. Hence, to collect high-quality data on the impact of COVID-19 pandemic on the prevalence of depression, anxiety, and insomnia symptoms among patients infected with SARS-CoV-2 should be the immediate priority.

Methods: A comprehensive search of Medline, Embase, Web of Science, and PsycINFO databases was conducted from January 1, 2020 to December 26, 2020 for eligible studies reporting on the prevalence of depression, anxiety, and insomnia symptoms in patients with COVID-19.

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