A new diphenyl ether with insecticidal activity from the mangrove endophytic fungus sp. GXNU-DY2-12.

A new diphenyl ether pseudopithoether C (), and five known compounds () were purified from secondary metabolites of the sp. GXNU-DY2-12 cultured in the rice medium. The new structure was analysed by NMR, HR-ESI-MS, and X-ray single crystal diffractometer.

Shexiang Baoxin Pills alleviate doxorubicin-induced cardiotoxicity via the reactive oxygen species-mediated AKT/Bcl-2 pathway.

Background: Shexiang Baoxin Pill (SBP) is a classical Chinese medicine that improves endothelial function and antioxidant and inflammatory responses. It may also alleviate doxorubicin (DOX)-induced cardiotoxicity. The aim of this study is to explore the potential influence and molecular mechanisms of SBP in DOX-induced cardiotoxicity using network pharmacology.

The utility of ultrasound-guided percutaneous needle biopsy for diagnosis of peripheral pulmonary lesions: A retrospective cohort study.

Objective: The aim of this study was to explore the diagnostic accuracy of ultrasound-guided (US-guided) percutaneous needle biopsy (PNB) and related influencing factors that could provide references for clinicians to improve the diagnostic accuracy of peripheral pulmonary lesions (PPLs).

Methods: We retrospectively analyzed 318 consecutive cases with PPLs who underwent US-guided PNB successfully in Chongqing Red Cross Hospital, Fusheng Community Health Service Center, Maoershi Community Health Service Center, and Yuzui Community Health Service Center. We collected pathological results of ultrasound-guided biopsy, clinical final diagnosis, disease course records, and postoperative complications of these patients.

A Comparative Study in Microstructure and Mechanical Properties of Symmetric and Asymmetric Double-Sided FSW Joints of AA7A65.

Double-sided friction stir welding (DS-FSW) demands a low requirement of the welding tool and equipment and can lower the heat input, showing advantages in joining thick-plate joints. However, the intrinsic twice thermal cycle inevitably leads to the twice grain growth and softening, troubling the performance of the joints. To alleviate this phenomenon, this work proposed an asymmetric DS-FSW (Asy-DS-FSW) in which the first weld and second weld are obtained via a large tool and a small tool, respectively.

The OsEBF1-OsEIL5-OsPP91 module regulates rice heat tolerance via ubiquitination and transcriptional activation.

Understanding the regulatory mechanisms underlying the plant heat stress response is important for developing climate-resilient crops, including rice (Oryza sativa). Here, we report that OsEIL5, one member of the ETHYLENE INSENSITIVE3-LIKE family, positively regulates rice heat tolerance at the seedling and reproductive stages. OsEIL5 directly binds to the promoter of OsPP91 (encoding one type 2C protein phosphatase) and activates its expression.

Oleanolic Acid Cubic Liquid Crystal Nanoparticle-Based Thermosensitive Gel Attenuates Depression Symptoms in Chronic Unpredictable Mild Stress Rats.

Purpose: Major depressive disorder (MDD) is a global health concern. Studies have demonstrated that oleanolic acid (OA) has a regulatory effect on MDD. However, OA is poorly soluble, has low oral bioavailability, and faces challenges in crossing the blood-brain barrier.

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity.

Background And Purpose: Nicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-Conotoxins, which are peptides derived from the venom of marine cone snails, target different subtypes of nAChRs.

Gastric cancer patient with amplification treated with crizotinib achieves long-term survival: a case report.

Background: Gastric cancer (GC) is one of the leading contributors to global malignancies incidence and mortality worldwide. Advanced GC had a relatively poor prognosis. The emerging of targeted therapy improved the survival and prognosis of GC patients.

Robot-Assisted Radical Prostatectomy Using the KangDuo Surgical Robot-1500: A Prospective, Multicenter, Single-Arm Clinical Study.

The KangDuo Surgical Robot-1500 (KD-SR-1500) is a newly developed surgical robot. We aim to evaluate the feasibility and efficiency of the KD-SR-1500 system for robot-assisted radical prostatectomy (RARP). This prospective, multicenter, single-arm clinical study was conducted among 18-75-year-old patients with suspected T1-2N0M0 prostate cancer scheduled for RARP.

The splicing auxiliary factor OsU2AF35a enhances thermotolerance via protein separation and promoting proper splicing of OsHSA32 pre-mRNA in rice.

Heat stress significantly impacts global rice production, highlighting the critical need to understand the genetic basis of heat resistance in rice. U2AF (U2 snRNP auxiliary factor) is an essential splicing complex with critical roles in recognizing the 3'-splice site of precursor messenger RNAs (pre-mRNAs). The U2AF small subunit (U2AF35) can bind to the 3'-AG intron border and promote U2 snRNP binding to the branch-point sequences of introns through interaction with the U2AF large subunit (U2AF65).

Osteoarthritis-like changes in rat temporomandibular joint induced by unilateral anterior large overjet treatment.

Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative disease that causes chronic pain and joint dysfunction. However, the current understanding of TMJOA pathogenesis is limited and necessitates further research. Animal models are crucial for investigating TMJOA due to the scarcity of clinical samples.

A nomogram predicting the risk of venous thromboembolism in patients following urologic surgeries.

There are inconsistent results pertaining to risk factors for venous thromboembolism (VTE) in patients following urologic surgeries. We attempted to establish a visualization model to shed further light upon this topic. Consequently, a total of 436 patients who were tested for VTE following urologic surgeries were retrospectively enrolled.

Bacillus amyloliquefaciens promotes cluster root formation of white lupin under low phosphorus by mediating auxin levels.

White lupin (Lupinus albus L.) produces cluster roots to acquire more phosphorus under phosphorus deficiency. Bacillus amyloliquefaciens SQR9 contributes to plant growth, but whether and how it promotes cluster root formation in white lupin remain unclear.

Elemental Sulfur/Selenium-Mediated Metal-Free Phosphinothioation and Phosphinoselenoation of Vinylsulfonium Salts with P-H Bonds.

An efficient and facile method has been developed for the construction of novel P-S-C and P-Se-C bonds by facilitating the three-component cross-coupling reaction of P-H bonds with elemental sulfur/selenium and vinylsulfonium salts, utilizing sodium bicarbonate as a base. This approach eliminates the need for the use of toxic and odorous active sulfur/selenium reagents and noble metals, thereby offering a new pathway for synthesizing -phosphinothioates and -phosphinoselenoates via the organic conversion of inorganic sources. The reaction has showcased remarkable versatility in terms of substrate applicability, particularly for organophosphorus compounds containing P-H bonds and vinylsulfonium salt derivatives.

Antimicrobial polyketides from an endophytic fungus HJ-7 from Hance.

Eleven polyketide derivatives, including two new compounds, xanthoradone D () and arisochromophilone (), were isolated from HJ-7, a Chinese medicinal plant Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The antibacterial and antifungal activities of the compounds were evaluated.

Iron-Catalyzed Cross-Dehydrogenative Coupling of -Quinone Methides with Formamides: Activation of C(sp)-H Bonds.

A novel and straightforward method for the iron-catalyzed regioselective cross-dehydrogenative coupling of -quinone methides (-QMs) with formamides has been developed, facilitated by the activation of the C(sp)-H bonds of the formyl and alkenyl substituents via a radical strategy. This method does not require the preactivation of the substrates, and it can accommodate a wide range of -QMs and formamides under the optimized reaction conditions, resulting in the formation of the expected C-7 acetamides-functionalized -quinone methides with moderate to good yields. The control experiments revealed that the reaction follows the fundamental equation of second-order kinetics.

Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp.

Phytochemical investigation of the stems of Mallotus paxii Pamp. led to the isolation and identification of four new compounds, including three neolignans (1-3) and one phenol (13), along with eight known neolignans (4-12) and one known phenol (14). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses.

Two new polyketone derivatives from the mangrove endophytic fungus GXNU TH4b.

Two new polyketones, exserone B () and cytosporone F (), along with three known metabolites, were isolated from the mangrove endophytic fungus TH4b. The structures of and were determined by detailed NMR, and MS spectroscopic data. The absolute configurations of and were determined by single crystal X-ray diffraction analysis and the combination of experimental ECD and computational ECD, respectively.

Feasibility, safety and effectiveness of robot-assisted radical prostatectomy with a new robotic surgical system: a prospective, controlled, randomized clinical trial.

Background: Robot-assisted radical prostatectomy (RARP) gains increasing popularity in the surgical management of prostate cancer (PCa) but is challenged by its prohibitive expense. A domestic robotic system has been developed to address this issue, but data comparing the self-developed robot with the widely used robot is lacking. We performed a randomized clinical trial to compare KD-SR-01 and DaVinci robots in terms of perioperative, short-term oncological and functional outcomes in RARP.

Transcriptomic and Hormonal Changes in Wheat Roots Enhance Growth under Moderate Soil Drying.

Understanding the mechanisms that regulate plant root growth under soil drying is an important challenge in root biology. We observed that moderate soil drying promotes wheat root growth. To understand whether metabolic and hormonic changes are involved in this regulation, we performed transcriptome sequencing on wheat roots under well-watered and moderate soil drying conditions.

Insights into the Pathogenesis and Treatment of Chemotherapy-Induced Neuropathy: A Focus on Oxidative Stress and Neuroinflammation.

Cancer is a high-morbidity disease prevalent worldwide. Chemotherapy is the primarily used regimen for cancer treatment; however, it also brings severe side effects. Chemotherapy-induced Peripheral Neuropathy (CIPN) and Chemotherapy-induced Cognitive Impairment (CICI) are two main complications occurring in chemotherapy.