Aberrant overexpression of myosin 1b in glioblastoma promotes angiogenesis via VEGF-myc-myosin 1b-Piezo1 axis.

Glioblastoma (GBM) is the most aggressive intracranial malignancy with poor prognosis. Enhanced angiogenesis is an essential hallmark of GBM, which demonstrates extensive microvascular proliferation and abnormal vasculature. Here, we uncovered the key role of myosin 1b in angiogenesis and vascular abnormality in GBM.

Molecular Insights into Soaking in Hybrid N-CO Huff-n-Puff: A Case Study of a Single Quartz Nanopore-Hydrocarbon System.

Hybrid N-CO huff-n-puff (HnP) has been experimentally demonstrated to be a promising approach for improving oil recovery from tight/ultratight shale oil reservoirs. Despite this, the detailed soaking process and interaction mechanisms remain unclear. Adopting molecular dynamic simulations, the soaking behavior of hybrid N-CO HnP was investigated at the molecular and atomic levels.

Learning Joint 2-D and 3-D Graph Diffusion Models for Complete Molecule Generation.

Designing new molecules is essential for drug discovery and material science. Recently, deep generative models that aim to model molecule distribution have made promising progress in narrowing down the chemical research space and generating high-fidelity molecules. However, current generative models only focus on modeling 2-D bonding graphs or 3-D geometries, which are two complementary descriptors for molecules.

Progress of Crude Oil Gasification Technology Assisted by Microorganisms in Reservoirs.

Crude oil gasification bacteria, including fermenting bacteria, hydrocarbon-oxidizing bacteria, reducing bacteria, and methanogenic bacteria, participate in multi-step reactions involving initial activation, intermediate metabolism, and the methanogenesis of crude oil hydrocarbons. These bacteria degrade crude oil into smaller molecules such as hydrogen, carbon dioxide, acetic acid, and formic acid. Ultimately, they convert it into methane, which can be utilized or stored as a strategic resource.

Study on the Effects of Wettability and Pressure in Shale Matrix Nanopore Imbibition during Shut-in Process by Molecular Dynamics Simulations.

Shut-in after fracturing is generally adopted for wells in shale oil reservoirs, and imbibition occurring in matrix nanopores has been proven as an effective way to improve recovery. In this research, a molecular dynamics (MD) simulation was used to investigate the effects of wettability and pressure on nanopore imbibition during shut-in for a typical shale reservoir, Jimsar. The results indicate that the microscopic advancement mechanism of the imbibition front is the competitive adsorption between "interfacial water molecules" at the imbibition front and "adsorbed oil molecules" on the pore wall.

The role of platelets in the blood-brain barrier during brain pathology.

Platelets play critical roles in maintaining hemostasis. The blood brain barrier (BBB), a significant physical and metabolic barrier, helps maintain physiological stability by limiting transportations between the blood and neural tissues. When the brain undergoes inflammation, tumor, trauma, or bleeding, the platelet responses to help with maintaining BBB homeostasis.

Effect of intramedullary nail fixation and internal plate fixation in distal tibia fracture surgery on post-operative wound infection in patients: A meta-analysis.

Distal tibial fracture is the most commonly seen type of fracture of the lower extremities. Both intramedullary nail fixation (INF) and plate fixation (PF) have been used to treat distal tibial fractures, but the best way to treat them is still in dispute. The purpose of this meta-analysis is to compare INF versus PF fixation with respect to the incidence of injury.

A negative capacitor emulator circuit and its application in chaotic circuits.

Negative capacitance usually exists in ferroelectric materials, and its instinct nonlinearity and negative capacitance render its potential applications. To date, the single negative capacitance device is commonly unavailable. Hence, it is necessary to build a negative capacitor emulator in hardware for further investigating its electrical characteristics and applications.

Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the "Lunar Palace 365" experiment.

Background: Psychological health risk is one of the most severe and complex risks in manned deep-space exploration and long-term closed environments. Recently, with the in-depth research of the microbiota-gut-brain axis, gut microbiota has been considered a new approach to maintain and improve psychological health. However, the correlation between gut microbiota and psychological changes inside long-term closed environments is still poorly understood.

Microbial communities in crude oil phase and filter-graded aqueous phase from a Daqing oilfield after polymer flooding.

Aims: The aim was to characterize indigenous micro-organisms in oil reservoirs after polymer flooding (RAPF).

Methods: The microbial communities in the crude oil phase (Oil) and in the filter-graded aqueous phases Aqu0.22 (>0.

Improving the Energy Density and Efficiency of the Linear Polymer PMMA with a Double-Bond Fluoropolymer at Elevated Temperatures.

A variety of applications can be found for high-temperature film capacitors, including energy storage components and pulsed power sources. In this work, in order to increase the energy density ( ), poly(vinylidene fluoride-chlorotrifluoroethylene-double bond) (P-DB) is introduced into poly(methyl methacrylate) (PMMA) to manufacture composite films by a solution casting process. In the case of the pure PMMA film, there is significant improvement in the polarization ( ) and breakdown field ( ) of the composite film.

Modelling the epidemic dynamics of COVID-19 with consideration of human mobility.

So far COVID-19 has resulted in mass deaths and huge economic losses across the world. Various measures such as quarantine and social distancing have been taken to prevent the spread of this disease. These prevention measures have changed the transmission dynamics of COVID-19 and introduced new challenges for epidemic modelling and prediction.

Differentiated embryonic chondrocyte-expressed gene 1 promotes temozolomide resistance by modulating the SP1-MGMT axis in glioblastoma.

Glioblastoma multiforme (GBM) is a malignant brain tumor with a high mortality rate and poor prognosis. Temozolomide (TMZ) is a first-line drug against GBM, but resistance limits its use. We previously reported that differentiated embryonic chondrocyte () expression is associated with TMZ resistance and poor prognosis in GBM; however, the underlying mechanism remains unclear.

Impact of temperature and relative humidity on the transmission of COVID-19: a modelling study in China and the United States.

Objectives: We aim to assess the impact of temperature and relative humidity on the transmission of COVID-19 across communities after accounting for community-level factors such as demographics, socioeconomic status and human mobility status.

Design: A retrospective cross-sectional regression analysis via the Fama-MacBeth procedure is adopted.

Setting: We use the data for COVID-19 daily symptom-onset cases for 100 Chinese cities and COVID-19 daily confirmed cases for 1005 US counties.

Adsorption behaviors of branched cationic gemini surfactants and wettability in quartz-solution-air systems.

The adsorption and wetting on quartz surfaces by aqueous solutions of xylyl-substituted biquaternary ammonium salt gemini surfactants with different spacer groups (C and C), have been investigated. The interfacial properties of surfactant solutions such as contact angle, adhesional tension (γ cos θ), quartz-water interfacial tension (γ) as well as adhesion work (W) have been estimated. The obtained results show that C and C have similar adsorption behavior on quartz surfaces.

Wetting of polymer surfaces by aqueous solutions of branched cationic Gemini surfactants.

The adsorption of xylyl-substituted biquaternary ammonium salt Gemini surfactants with different spacer (C3 and C6) at polytetrafluoroethylene (PTFE) and polymethylmethacrylate (PMMA) surfaces has been investigated and the different adsorption parameters such as surface tension, contact angle, adhesional tension, solid-water interfacial tension and work of adhesion have been estimated. The results show that C3 and C6 have similar adsorption behaviors at PTFE and PMMA surfaces. C3 and C6 adsorb gradually at a PFTE-water interface via hydrophobic interactions and the adsorption amounts at the water-air interface are almost three times higher than those at the PTFE-water interface due to the steric hindrance effect.

VO(B) nanobelts/reduced graphene oxide composites for high-performance flexible all-solid-state supercapacitors.

Vanadium oxide has attracted extensive attention for electrochemical capacitors due to its wide range of versatility. However, due to the relative poor conductivity and chemical stability of vanadium oxide, severe losses of capacitance often occur during charge and discharge processes. Herein, a free-standing vanadium dioxide (VO(B)) nanobelts/reduced graphene oxide (VO/rGO) composite film was fabricated by assembly of VO(B) nanobelts and rGO for supercapacitors.

IDH2 compensates for IDH1 mutation to maintain cell survival under hypoxic conditions in IDH1‑mutant tumor cells.

Mutations of isocitrate dehydrogenase (IDH) 1 and 2 occur in low‑grade gliomas, acute myeloid leukemias and other types of solid cancer. By catalyzing the reversible conversion between isocitrate and α‑ketoglutarate (α‑KG), IDH1 and 2 contribute to the central process of metabolism, including oxidative and reductive metabolism. IDH1 and 2 mutations result in the loss of normal catalytic function and acquire neomorphic activity, facilitating the conversion of α‑KG into an oncometabolite, (R)‑2‑hydroxyglutarate, which can cause epigenetic modifications and tumorigenesis.

MiR-7-5p suppresses stemness and enhances temozolomide sensitivity of drug-resistant glioblastoma cells by targeting Yin Yang 1.

Glioblastoma multiforme (GBM) is the most malignant tumor of the central nervous system, and chemoresistance blunts the effect of temozolomide (TMZ) in the treatment of GBM. Clarifying the underlying mechanism of chemoresistance might yield novel strategies to improve the patients' response to chemotherapeutics. Mounting evidence indicates that microRNAs (miRNAs) are involved in chemoresistance and tumorigenesis.

One-Pot Synthesis of Multi-Branch Gold Nanoparticles and Investigation of Their SERS Performance.

Gold nanoparticles with multiple branches have attracted intensive studies for their application in sensing of low trace molecules. A large number of the merits found on the gold nanoparticles for the above applications are attributed to the strong localized surface plasmon resonance excited by the incident radiation. However, a facile and flexible way of synthesizing the multi-branch gold nanoparticles with tunable localized surface plasmon resonance frequency is still a challenge for the plasmonic research field.

A target-triggered dual amplification strategy for sensitive detection of microRNA.

The accurate and quantitative analysis of microRNA (miRNA) expression is critical for biomedical research and clinical theranostics. In this study, we report a novel sensor for the sensitive detection of miRNA based on a duplex-specific nuclease (DSN)-assisted dual signal amplification strategy. A chimeric probe (DNA/2-OMe-RNA) that consists of a miRNA recognition DNA sequence and a Taqman probe hybridization RNA sequence (2'-O-methyl RNA) was designed and synthesized.

The Value of Extended Nursing Services on Patients with Bladder Cancer after Endoscopic Bladder Resection.

Background: In this study, specific measures of extended nursing services and its values on patients with bladder cancer after endoscopic bladder electrosection were examined.

Methods: Sixty-six patients diagnosed with bladder cancer in Laiwu People's Hospital(NO. 001, Xueyehu Street, Changshao Road, Laiwu, Shandong, China) between February 2012 and February 2014, and underwent endoscopic bladder electrosection were enrolled in the study.