Publications by authors named "Weifeng He"

Atherosclerosis (AS) is a major cause of mortality worldwide. Geniposide (GP) has lipolytic and anti-inflammatory effects and is widely administered for the treatment of cardiovascular disease. There is considerable evidence for the importance of autophagy in the cardiovascular system, and GP can promote autophagy and improve AS.

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  • Hypertrophic scars negatively impact both the appearance and function of skin, affecting individuals' physical and mental well-being, necessitating better experimental models for research due to limitations in human specimen collection.
  • Existing animal models for hypertrophic scarring, such as the rabbit ear and mouse models, have significant drawbacks like prolonged setup time, high costs, and instability, prompting the development of a new mouse model.
  • The new model utilizes suture anchoring to apply directional tension on healing incisional wounds, leading to notable fibrotic changes and confirming its effectiveness through various analyses, demonstrating structured alterations associated with hypertrophic fibrosis.
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  • A study compared a new blood collection technique from mice, called inferior vena cava puncture under continuous cardiac perfusion (IVCP-UCCP), to the traditional cardiac puncture (CP) method.
  • The results revealed that IVCP-UCCP collected over twice the amount of usable blood compared to CP, without affecting blood cell composition or viability.
  • This improved method allows for more efficient use of limited blood resources in mice, offering benefits for both scientific research and ethical considerations, and could be applied to other small animal models as well.
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  • This text indicates that there is an error in a previously published article with the DOI: 10.1039/C8RA03234C.
  • The document serves to correct specific information or data in that article.
  • It is important for readers to refer to this correction to ensure they have accurate and up-to-date information.
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Sepsis is a severe medical condition characterized by a systemic inflammatory response, often culminating in multiple organ dysfunction and high mortality rates. In recent years, there has been a growing recognition of the pivotal role played by mitochondrial damage in driving the progression of sepsis. Various factors contribute to mitochondrial impairment during sepsis, encompassing mechanisms such as reactive nitrogen/oxygen species generation, mitophagy inhibition, mitochondrial dynamics change, and mitochondrial membrane permeabilization.

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Aims: This study evaluated millet germplasms in Liaoning Province to support the collection, preservation and innovation of millet germplasm resources.

Methods: The study was conducted from 2018 to 2020, involved the selection of 105 millet germplasm resources from the Germplasm Bank of the Liaoning Academy of Agricultural Sciences (LAAS), the observation and recording of 31 traits, and the application of multivariate analysis methods to assess phenotypic diversity.

Results: From the diversity analysis and correlation analysis, it was found that the tested traits had abundant diversity and complex correlations among them.

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  • - STING is identified as a vital immune mediator that helps resolve inflammation and aids in skin repair by regulating the movement and function of macrophages during wound healing.
  • - Mice lacking STING showed delayed wound healing due to persistent TNF-α+ leukocytes and impaired recruitment of macrophages, highlighting its role in controlling myeloid cell trafficking to wounds.
  • - The study reveals that STING enhances macrophage migration through STAT3 activation and regulates chemokine production, suggesting potential therapeutic targets for enhancing wound healing and treating inflammatory diseases.
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Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay of signaling pathways, transcriptional regulators, and epigenetic modifications orchestrates macrophage polarization, allowing them to respond to various stimuli dynamically.

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Background: More and more evidence supports the association between myocardial infarction (MI) and osteoarthritis (OA). The purpose of this study is to explore the shared biomarkers and pathogenesis of MI complicated with OA by systems biology.

Methods: Gene expression profiles of MI and OA were downloaded from the Gene Expression Omnibus (GEO) database.

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With increasing prevalence rate of depression by years, more attention has been paid to the influence of environmental pollutants on depression, but relationship between exposure to volatile organic compounds (VOCs) and depression is rarely studied. Therefore, this cross-sectional study use the National Center for Health Statistics (NHANES) database (2013-2016 years) to explore association between exposure to multiple VOCs and depression in general population. Multiple linear and logistic regression models were used to analyze the association between urinary VOC metabolism (mVOCs) and depression.

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  • * Doctors reviewed their medical records and found that two had stromal sarcoma and one had spindle cell sarcoma, which are types of high-grade cancers.
  • * The researchers concluded that this cancer is very rare and usually doesn't have a good outcome, so early detection and treatment are super important, but recurrence is still a big risk even after treatment.
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As the reliability and lifespan requirements of modern equipment continues to escalate, the problems with very high cycle fatigue (VHCF) has obtained increasingly widespread attention, becoming a hot topic in fatigue research. Titanium alloys, which are the most extensively used metal materials in the modern aerospace industry, are particularly prone to VHCF issues. The present study systematically reviewed and summarized the latest (since 2010) developments in VHCF research on titanium alloy, with special focus on the (i) experimental methods, (ii) macroscopic and microscopic characteristics of the fatigue fractures, and (iii) construction of fatigue fracture models.

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Manganese (Mn) exposure is a common environmental risk factor for Parkinson's disease (PD), with pathogenic mechanisms associated with dopaminergic neuron damage and neuroinflammation. Mesenchymal stem cells (MSCs)-derived small extracellular vesicles (sEVs) have emerged as a novel therapeutic approach for neural damage repair. The functional sEVs released from MSCs when they are induced into dopaminergic progenitors may have a better repair effect on neural injury.

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Size is one of the important bases for the level assessment of aero-engine blade damage and the disposal method selection for damaged blades. Therefore, research on in-situ damage measurement of aero-engine blades is conducted in this paper. We break the inherent pipeline of "3D reconstruction and manual annotation of keypoints" in traditional damage measurement methods, and propose an in-situ damage automatic measurement method (KBMeasure) based on the combination of damage keypoints intelligent detection and binocular 3D reconstruction.

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  • Macrophages play dual roles in skin wound healing, switching from proinflammatory (M1) to anti-inflammatory (M2) states, which is crucial for effective recovery.
  • The study identifies fibroblast-derived exosomes as key players that regulate this transition in macrophage activation without direct cell contact, enhancing their responsiveness to changes in the healing environment.
  • Administering these exosomes can correct dysfunctional inflammation in chronic wounds, presenting a promising therapeutic avenue for improving healing in inflammatory conditions.
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Dysregulated macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotypes underlies impaired cutaneous wound healing. This study reveals Vγ4 γδ T cells spatiotemporally calibrate macrophage trajectories during skin repair via sophisticated interferon-γ (IFN-γ) conditioning across multiple interconnected tissues. Locally within wound beds, infiltrating Vγ4 γδ T cells directly potentiate M1 activation and suppress M2 polarization thereby prolonging local inflammation.

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Manganese (Mn), a common environmental and occupational risk factor for Parkinson's disease (PD), can cause central nervous system damage and gastrointestinal dysfunction. The melatonin has been shown to effectively improve neural damage and intestinal microbiota disturbances in animal models. This research investigated the mechanism by which exogenous melatonin prevented Mn-induced neurogenesis impairment and neural damage.

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Background: Prostate cancer (PCa) is one of the most common malignant tumors in men, and laparoscopic radical prostatectomy (LRP) is commonly used to treat localized and advanced PCa. Positive surgical margin (PSM) is one of the most frequent problems faced by surgeons.

Aims: This study aimed to explore the value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) in predicting PSM after LRP.

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Background: is an herbal medicine widely used in the treatment of atrial fibrillation (AF), but the mechanism is unclear.

Objective: To explore the molecular mechanism of against AF.

Methods: The TCMSP was used to screen the active compounds and their targets.

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  • * The system demonstrated a sustained H concentration of 3.35 mol/L at 80 °C after 180 minutes, indicating its potential for continuous acid generation for acidizing and plugging removal.
  • * Corrosion testing revealed low corrosion rates on N80 steel, and a core displacement experiment showed a significant increase in permeability after acid treatment, highlighting the system's effectiveness and safety for reservoir applications.
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Emerging evidence indicates that cancer cells can mimic characteristics of embryonic development, promoting their development and progression. Cancer cells share features with embryonic development, characterized by robust proliferation and differentiation regulated by signaling pathways such as Wnt, Notch, hedgehog, and Hippo signaling. In certain phase, these cells also mimic embryonic diapause and fertilized egg implantation to evade treatments or immune elimination and promote metastasis.

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Manganese (Mn) is considered as an important environmental risk factor for Parkinson's disease. Excessive exposure to Mn can damage various neural cells and affect the neurogenesis, resulting in neurological dysfunction. However, the specific mechanisms of Mn exposure affecting neurogenesis have not been well understood, including compositional changes and heterogeneity of various neural cells.

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  • Advanced anti-inflammatory hydrogel dressings have been developed to improve wound healing, particularly in cases of deep second-degree burns that are often complicated by excessive inflammation.
  • The customized hydrogel platform, made from sulfated alginates and loaded with Prussian blue nanozymes, effectively reduces harmful reactive oxygen species and limits inflammatory cell infiltration by mimicking components of the extracellular matrix.
  • In animal studies, these hydrogels have shown promising results in promoting healing processes like blood vessel formation, tissue regeneration, and overall wound closure, marking a significant advancement in clinical anti-inflammatory treatments.
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  • * Researchers identified 26 common genes linked to both MI and AD, primarily related to inflammatory pathways, using various analytical techniques like LASSO regression and protein-protein interaction networks.
  • * The study highlighted Regulator of G-protein Signaling 1 (RGS1) as a significant gene involved, especially in immune cells like macrophages and microglia, suggesting its potential role as a biomarker for inflammation in both diseases.
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