Publications by authors named "Weien Chow"

Article Synopsis
  • Cardiorespiratory fitness (CRF) in young adulthood affects the risk of chronic diseases, prompting a study on how changes in 2.4 km run times relate to health outcomes in healthy young men.
  • An analysis of data from 148,825 men ages 18-34 indicated that poor run time performance was linked to a higher risk of major cardiovascular events and all-cause mortality later in life.
  • The study concluded that a decline in run times over time correlates with an increased risk of cardiovascular issues, suggesting that improving fitness could be a potential modifiable risk factor for long-term health.
View Article and Find Full Text PDF
Article Synopsis
  • The study used a multi-state model to assess the impact of MRSA infections on mortality, length of hospital stay (LOS), and healthcare costs in Singapore from 2018 to 2022.
  • 536 patients with MRSA infections were compared to matched groups with MRSA colonization and without MRSA, revealing that MRSA infections resulted in an extra 2.11 to 3.75 days of hospital stay and significant additional costs.
  • The research highlighted that pneumonia due to MRSA had the highest risk of mortality, emphasizing the need for effective management strategies to combat MRSA in healthcare settings.
View Article and Find Full Text PDF
Article Synopsis
  • This study focused on understanding the yearly healthcare costs associated with heart failure (HF) patients in Singapore, specifically those with reduced ejection fraction (<40%).
  • It analyzed data from 2011 through 2019, showing a decline in hospital admissions overall while noting stable per-patient admission costs, which ranged from S$16,000 to S$18,800 annually.
  • The findings indicate that healthcare costs significantly increase in the final year of life, highlighting the need for more cost-effective management approaches to alleviate financial strain on Singapore's healthcare system.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates undiagnosed cardiovascular risk factors, like elevated lipoprotein(a), in patients with ischaemic heart disease (IHD).
  • Among the 555 patients, newly diagnosed individuals showed a significantly higher prevalence of hypertension, hypercholesterolemia, and type 2 diabetes compared to those with known IHD.
  • The findings suggest a need for improved detection of chronic metabolic diseases in high-risk patients, highlighting the importance of monitoring factors like Lp(a) levels, smoking habits, and dietary intake.
View Article and Find Full Text PDF

BACKGROUND Electrocardiography (ECG) may be performed as part of preparticipation sports screening. Recommendations on screening of athletes to identify individuals with previously unrecognized cardiac disease are robust; however, data guiding the preparticipation screening of unselected populations are scarce. T wave inversion (TWI) on ECG may suggest an undiagnosed cardiomyopathy.

View Article and Find Full Text PDF

Background: Wolff-Parkinson-White (WPW) syndrome is a proarrhythmic condition that may require restriction from strenuous activities and is characterized by ECG signs, including delta waves. We observed cases of intermittent WPW patterns presenting as QRS alternans ('WPW alternans') in a large pre-participation ECG screening cohort of young men reporting for military conscription.

Objectives: We aimed to determine the WPW alternans pattern, case characteristics, and the prevalence of other relevant differential diagnoses presenting as QRS alternans in a pre-participation setting.

View Article and Find Full Text PDF

A 54-year-old man on maintenance hemodialysis with recurrent catheter-related bloodstream infections due to was admitted. Multiple prior transthoracic echocardiograms failed to reveal any vegetation. Subsequently on transesophageal echocardiography a mass consistent with fibrin sheath vegetations was identified and a follow-up diagnostic computed tomography (CT) venogram confirmed the presence of a fibrin sheath with vegetations.

View Article and Find Full Text PDF

Background: Large-scale quarantine facilities staffed with non-healthcare workers (NHCW) were instrumental in preventing community spread of COVID-19 (coronavirus disease of 2019). The objective of this study was to determine the effectiveness of a newly developed procedural skills training framework in ensuring personal protective equipment (PPE) compliance of PPE-naïve NHCWs.

Methods: We developed a PPE procedural skills training framework for NHCWs using the Learn, See, Practice, Prove, Do, and Maintain (LSPPDM) framework and international guidelines on PPE for healthcare workers.

View Article and Find Full Text PDF

Background: Classical electrocardiographic (ECG) criteria for left ventricular hypertrophy (LVH) are well studied in older populations and patients with hypertension. Their utility in young pre-participation cohorts is unclear.

Aims: We aimed to develop machine learning models for detection of echocardiogram-diagnosed LVH from ECG, and compare these models with classical criteria.

View Article and Find Full Text PDF

Introduction: The health, psychological and socioeconomic vulnerabilities of low-wage migrant workers have been magnified in the COVID-19 pandemic, especially in high-income receiving countries such as Singapore. We aimed to understand migrant worker concerns and coping strategies during the COVID-19 pandemic to address these during the crisis and inform on comprehensive support needed after the crisis.

Methods: In-depth semi-structured interviews were carried out with migrant workers diagnosed with COVID-19.

View Article and Find Full Text PDF

Background: Routine use of pre-participation electrocardiograms (ECGs) has been used by the Singapore Armed Forces, targeting early detection of significant cardiac diseases. We aim to describe the impact of demographic and anthropometric factors on ECG variables and establish a set of electrocardiographic reference ranges specific to a young male multiethnic Southeast Asian cohort.

Methods And Results: Between November 1, 2009, and December 31, 2014, 144,346 young male conscripts underwent pre-participation screening that included a 12-lead ECG, demographic and anthropometric measurements.

View Article and Find Full Text PDF

Introduction: Mutations within SCN5A are found in a significant proportion (15-30%) of Brugada syndrome (BrS) cases and impair sodium transport across excitable cardiac cells that mediate ventricular contractions. Genetic testing offers a means to clinically assess and manage affected individuals and their family members.

Methods And Results: The proband at age 44 years old exhibited a syncopal event during exercise, and presented later with a spontaneous type-I BrS pattern on 12‑lead resting electrocardiogram (ECG).

View Article and Find Full Text PDF

The emphasis of naval operations has shifted from conventional naval warfare since World War II to Operations Other than War such as Peace Support Operations and Humanitarian Aid and Disaster Relief. Maritime forces are increasingly deployed in distant areas of operations such as the Somali Basin and Gulf of Aden for longer durations, in a possibly higher threat environment against nonconventional threats such as in counter piracy operations. There is therefore a need to balance the challenges of providing adequate forward naval surgical support with limitations in medical manpower, logistics as well as the need for a suitable surgical platform for these deployments.

View Article and Find Full Text PDF
Article Synopsis
  • Brugada syndrome (BrS) is a rare hereditary heart condition often linked to mutations in the SCN5A gene, which plays a critical role in sodium ion channel function; it is responsible for 15-30% of cases.
  • A young male proband experienced syncopal episodes and was found to carry two mutations in the SCN5A gene inherited from his parents, leading to significant abnormalities during stress testing and a high risk for dangerous heart rhythms.
  • This study highlights the unique presentation of compound heterozygote mutations in a Singaporean Chinese family, suggesting variations in how BrS manifests in different populations.
View Article and Find Full Text PDF

Introduction: Spinal cord decompression sickness (DCS) is a rare condition that can lead to spinal cord infarction. Despite the low incidence of diving-related DCS, we have managed to collect the data and MRI findings of seven patients who have been diagnosed with and treated for DCS in our local hyperbaric facility. This study describes the clinical presentation, MRI spinal cord findings, treatment administered and outcome of these patients.

View Article and Find Full Text PDF