Prognostic nutritional index (PNI) is an independent predictor for functional outcome after hip fracture in the elderly: a prospective cohort study.

Unlabelled: The prognostic nutritional index (PNI) is a useful tool for assessing nutritional status using serum albumin and lymphocyte count. This study indicates that a higher preoperative PNI correlates with improved mobility and health-related quality of life during the initial postoperative period in elderly patients with hip fractures.

Purpose: To investigate the prognostic value of the prognostic nutritional index (PNI) in predicting mobility and health-related quality of life (HRQoL) in elderly hip fracture patients after surgery.

Inhibition of JNK Signaling Overcomes Cancer-Associated Fibroblast-Mediated Immunosuppression and Enhances the Efficacy of Immunotherapy in Bladder Cancer.

Currently, only 20% to 40% of patients with cancer benefit from immune checkpoint inhibitors. Understanding the mechanisms underlying the immunosuppressive tumor microenvironment (TME) and characterizing dynamic changes in the immunologic landscape during treatment are critical for improving responsiveness to immunotherapy. In this study, we identified JNK signaling in cancer-associated fibroblasts (CAF) as a regulator of the immunosuppressive TME.

Association between admission inflammatory indicators and 3-year mortality risk in geriatric patients after hip fracture surgery: a retrospective cohort study.

Background: Recent research indicates that the monocyte lymphocyte ratio (MLR), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), C-reactive protein (CRP), and systemic immune-inflammation index (SII) may serve as valuable predictors of early postoperative mortality in elderly individuals with hip fractures. The primary objective of the study was to examine the association between preoperative MLR, NLR, PLR, CRP, and SII levels and 3-year mortality risk in geriatric patients after hip fracture surgery.

Patients And Methods: The study included patients aged 65 years or older who underwent hip fracture surgery between November 2018 and November 2019.

Prognostic Nutritional Index (PNI) as an Independent Predictor of 3-Year Postoperative Mortality in Elderly Patients with Hip Fracture: A Post hoc Analysis of a Prospective Cohort Study.

Objective: The prognostic nutritional index (PNI) has been reported as a significant predictor in various diseases. However, the prognostic value of the PNI in geriatric hip fracture patients has not been thoroughly evaluated. This study aimed to investigate the association between admission PNI and 3-year mortality in those patients.

Preoperative Thyroid-Stimulating Hormone Levels and Three-Year Mortality in Elderly Hip Fracture Patients: Insights from a Prospective Cohort Study.

BACKGROUND It is unclear whether preoperative thyroid-stimulating hormone (TSH) level is correlated with long-term mortality in the elderly after hip fracture surgery. We aimed to assess the association between TSH levels and 3-year mortality in these patients. MATERIAL AND METHODS We enrolled patients aged 65 and above who had hip fracture surgery and thyroid function tests upon admission from 2018 to 2019.

Epidemiological trends and mid-term to long-term outcomes of acetabular fractures in the elderly in China.

Purpose: To explore the epidemiological trends in acetabular fracture and report the mid-term to long-term clinical outcomes of the elderly treated with operation.

Methods: Retrospective study. Patients aged ≥ 14 years with operative treatment of the Acetabular fracture from Jan 2010 to Dec 2019 at a level-1 trauma centre were identified to analyze the epidemiological trends, and the difference in fracture patterns between young and elderly patients (≥ 60 years old) were compared.

Growth of Ag/g-CN nanocomposites on nickel foam to enhance photocatalytic degradation of formaldehyde under visible light.

Formaldehyde is a pollutant that significantly affects the indoor air quality. However, conventional remediation approaches can be challenging to deal with low-concentration formaldehyde in an indoor environment. In this study, Photocatalysts of Ag/graphitic carbon nitride (g-CN)/Ni with 3D reticulated coral structure were prepared by thermal polymerization and liquid phase photo-deposition, using nickel foam (NF) as the carrier.

Orthogeriatric co-managements lower early mortality in long-lived elderly hip fracture: a post-hoc analysis of a prospective study.

Objective: To evaluate the clinical effectiveness of orthogeriatric co-management care in long-lived elderly hip fracture patients (age ≥ 90).

Methods: Secondary analysis was conducted in long-lived hip fracture patients between 2018 to 2019 in 6 hospitals in Beijing, China. Patients were divided into the orthogeriatric co-management group (CM group) and traditional consultation mode group (TC group) depending on the management mode.

Tumor-activated neutrophils promote metastasis in breast cancer via the G-CSF-RLN2-MMP-9 axis.

The immune component of the tumor microenvironment is essential for the regulation of cancer progression. In breast cancer (BC), a patient's tumor mass is frequently infiltrated by neutrophils (tumor-associated neutrophils, TANs). Our study addressed the role of TANs and their mechanism of action in BC.

Modified chair method: an easy and efficient reduction method without medication for anterior shoulder dislocation.

Background: Various maneuvers have been introduced to address anterior shoulder dislocations. Chair method allows the patient to sit comfortably and feel less pain during the reduction procedure. However, the rarity of comparative studies led to a lack of evidence to popularize.

Development and validation of a prediction model for tuberculous pleural effusion: a large cohort study and external validation.

Background: Distinguishing tuberculous pleural effusion (TPE) from non-tuberculosis (TB) benign pleural effusion (BPE) remains to be a challenge in clinical practice. The aim of the present study was to develop and validate a novel nomogram for diagnosing TPE.

Methods: In this retrospective analysis, a total of 909 consecutive patients with TPE and non-TB BPE from Ningbo First Hospital were divided into the training set and the internal validation set at a ratio of 7:3, respectively.

Lung Adenocarcinoma Cells Promote Self-Migration and Self-Invasion by Activating Neutrophils to Upregulate Notch3 Expression of Cancer Cells.

Invasion and migration of cancer cells play a key role in lung cancer progression and metastasis. Tumor-associated neutrophils (TANs) are related to poor prognosis in many types of cancer. However, the role of TANs in lung cancer is controversial.

Development and Validation of a Scoring System for Early Diagnosis of Malignant Pleural Effusion Based on a Nomogram.

Background: The diagnostic value of clinical and laboratory features to differentiate between malignant pleural effusion (MPE) and benign pleural effusion (BPE) has not yet been established.

Objectives: The present study aimed to develop and validate the diagnostic accuracy of a scoring system based on a nomogram to distinguish MPE from BPE.

Methods: A total of 1,239 eligible patients with PE were recruited in this study and randomly divided into a training set and an internal validation set at a ratio of 7:3.

Tumor-associated neutrophils activated by tumor-derived CCL20 (C-C motif chemokine ligand 20) promote T cell immunosuppression via programmed death-ligand 1 (PD-L1) in breast cancer.

Breast cancer is the leading cause of cancer-related death among women despite the significant improvement in diagnosis and treatment. Tumor-associated neutrophils have been shown to suppress antitumor functions of the host. However, how breast cancer tumor microenvironment influences the phenotype and functions of neutrophils to potentiate T cell immunosuppression is unknown.

Laser fabricated carbon quantum dots in anti-solvent for highly efficient carbon-based perovskite solar cells.

Additive passivation can be an effective strategy to regulate and control the properties of organic-inorganic halide perovskite film. In this article, carbon quantum dots (CQDs), fabricated by non-focused laser irradiation of carbon nanomaterial diluted in anti-solvent ethyl acetate, denoted as EACQDs, were adopted for perovskite film defect passivation and modification of carbon-based CHNHPbI perovskite solar cells (PSCs). The size of EACQDs can be tuned by manipulating the laser fluence.

BiO and g-CN quantum dot modified anatase TiO heterojunction system for degradation of dyes under sunlight irradiation.

A facile and feasible method was successfully utilized to incorporate BiO and g-CN quantum dots on TiO surface to synthesize a novel composite g-CN/TiO/BiO. The photocatalytic activity of the composite g-CN/TiO/BiO for degradation of dyes under sunlight and UV light irradiation was evaluated. It possessed the higher photocatalytic performance than that of pristine TiO or g-CN under the same conditions.

Author Correction: Novel multilayer TiO heterojunction decorated by low g-CN content and its enhanced photocatalytic activity under UV, visible and solar light irradiation.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Endobronchial Ultrasound-Guided Iodine-125 Radioactive Seed Implantation as a Novel Therapy for Mediastinal Tumors.

This study aims to test the treatment effect of endobronchial ultrasound (EBUS)-guided interstitial iodine-125 (I) seed implantation for mediastinal lymph node metastasis or advanced mediastinal lung cancer. The patients with mediastinal lymph node metastasis or advanced mediastinal lung cancer, who had undergone surgery for resection of primary lesions and repeated chemotherapy or external radiotherapy, were selected and scheduled to undergo EBUS-guided I seed implantation from December 2015 to May 2017. Forty patients were included into this study.

Novel multilayer TiO heterojunction decorated by low g-CN content and its enhanced photocatalytic activity under UV, visible and solar light irradiation.

In this paper, we used a facile ball milling, microwave radiation and heating treatment method to achieve the surface modification of TiO with low g-CN concentration, and a multilayer heterojunction composite with TiO as the main part and g-CN as the modification agent was obtained. The obtained materials were analyzed by several characterizations to get information on their chemical composition, crystalline structure, vibrational features and optical properties. The photocatalytic performance was evaluated by degradation of rhodamine B (RhB) and methylene blue (MB) under UV, visible and direct solar light irradiation.

Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326 in Lung Adenocarcinoma Cells.

Circular RNAs (circRNAs) represent a new class of noncoding RNAs that is involved in the development of cancer. However, little is known about their role in chemoresistance. In the present study, we found that hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and docetaxel-resistant cell lines (A549/DTX and H1299/DTX) were upregulated.

Genetic Diversity of in China Assessed Using Simple Sequence Repeat Markers.

The giant roundworm infects pigs and people worldwide and causes serious diseases. The taxonomic relationship between and is still unclear. The purpose of the present study was to investigate the genetic diversity and population genetic structure of 258 specimens from humans and pigs from 6 sympatric regions in -endemic regions of China using existing simple sequence repeat data.

LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non-small cell lung cancer cells.

Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non-small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis.

Construction of a Graphene/Au-Nanoparticles/Cucurbit[7]uril-Based Sensor for Pb(2+) Sensing.

The development of highly sensitive and selective methods for the detection of lead ion (Pb(2+)) is of great scientific importance. In this work, we develop a new surface-enhanced Raman scattering (SERS)-based sensor for the selective trace measurement of Pb(2+). The SERS-based sensor is assembled from gold nanoparticles (AuNPs) and graphene using cucurbit[7]uril (CB[7]) as a precise molecular glue and a local SERS reporter.