Publications by authors named "Weide Xiao"
Article Synopsis
- Disrupted methyladenosine (mA) modification is linked to inflammatory skin disorders, with reduced levels observed in keratinocytes affected by these conditions.
- The deletion of mA in mouse keratinocytes triggers spontaneous skin inflammation and intensifies neutrophil activity, worsening inflammation.
- Restoring mA can relieve skin disease symptoms in both mice and human skin samples, suggesting a new therapeutic approach focusing on mA modulation to treat inflammatory skin diseases.
DNA glycosylases must distinguish the sparse damaged sites from the vast expanse of normal DNA bases. However, our understanding of the nature of nucleobase interrogation is still limited. Here, we show that hNEIL1 (human endonuclease VIII-like 1) captures base lesions via two competing states of interaction: an activated state that commits catalysis and base excision repair, and a quarantine state that temporarily separates and protects the flipped base via auto-inhibition.
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