Publications by authors named "Weicheng Shen"

An ideal green leaf-deposited pesticide formulation should offer advantages such as good water dispersibility, strong foliar affinity, sustained or controlled release of active ingredients, photostability and rain-fastness, minimal nontarget toxicity, use of nontoxic organic solvents, and degradable adjuvants. In line with this objective, we present green preparation of a colloidal pesticide formulation using optimized lysine-derived carbon dots (LysCDs)-modified CaCO (LysCDs/CaCO) particles as the carrier and abamectin (Abm) as the active ingredient. The loading capacity of abamectin in this colloidal pesticide (LysCDs/CaCO/Abm) is 1.

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  • Blade-coating techniques for perovskite solar cells (PSCs) are appealing due to their efficiency in precursor use and ease of application, but they struggle with lower power conversion efficiency (PCE) compared to spin-coated cells because of issues in controlling film formation.
  • A new three-step strategy using glycine amide hydrochloride has been developed to improve perovskite film quality by managing pre-nucleation and crystallization processes, resulting in better crystal formation and reduced defects.
  • The enhanced blade-coated PSCs achieved a maximum PCE of 19.97%, and two-terminal tandem cells using this method reached a stabilized PCE of 26.87%, demonstrating potential for high-performance solar energy devices.
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Research has not demonstrated whether multiple cups of negative pressure cupping therapy would induce interactions of hemodynamic responses between different areas. A multichannel near-infrared spectroscopy (NIRS) was used to assess oxyhemoglobin and deoxyhemoglobin oscillations in response to cupping therapy. Wavelet transform and wavelet phase (WPC) coherence were used to quantify NIRS signals.

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  • - Bioluminescence imaging (BLI) is a sensitive and noninvasive technique used in biological monitoring, but it faces limitations due to the need for added luciferase and the short duration of its substrate, firefly luciferin.
  • - To address these issues, researchers developed a method using luciferase-loaded calcium phosphate nanoparticles and a new probe that generates amino luciferin slowly, allowing for longer tracking of tumors.
  • - This innovative approach enhances luciferase activity for at least 12 hours and extends bioluminescence duration by 2 hours, potentially paving the way for improved disease diagnosis and treatment in clinical settings.
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  • Gliomas are "immune-desert" tumors with limited immune response, making them resistant to immunotherapies; the study investigates ways to create lymphoid structures within the glioma microenvironment to boost immunity.
  • Researchers induced the formation of these structures using TLR agonists and glioma antigens, employing various scientific techniques to understand how this promotes anti-glioma immunity.
  • Results showed that inducing these structures led to increased immune cell activity and better outcomes in glioma-bearing mice, implying that targeting the microenvironment could enhance treatment strategies for glioma in humans.
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  • Narrow-bandgap mixed tin-lead perovskite solar cells (PSCs) are essential for improving the efficiency of all-perovskite tandem solar cells (TSCs), but traditional hole transport layers (HTLs) limit their performance.
  • The study introduces acetylcholine chloride (ACh) as a strategy to enhance the buried interface of Sn-Pb perovskites, leading to better quality layers, reduced defects, and prevention of tin oxidation.
  • The optimized NBG PSCs show a significant efficiency increase to 22.98% and improved stability, enabling TSCs to achieve even higher efficiencies of up to 28.01%.
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Patients with scars face a grave threat to their mental and physical health. Negative pressure has been used for scar therapy in medical care and provides a microenvironment conducive to scar healing while stimulating cell regeneration. Negative pressure may disrupt scar tissue regeneration when the pressure is too high or too low, so finding a suitable negative pressure is important.

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Clinically, air insoles may be applied to shoes to decrease plantar pressure gradient (PPG) and increase plantar gradient angle (PGA) to reduce foot ulcers. PPG and PGA may cause skin breakdown. The effects of different inner pressures of inflatable air insoles on dynamic PPG and PGA distributions are largely unknown in non-diabetics and people with diabetes.

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  • Exercise can help reduce complications for people with diabetes and vascular diseases, and using air insoles may lower the risk of diabetic foot ulcers by reducing peak plantar pressure (PPP).
  • The study tested 13 participants with different air insole pressures (80, 160, and 240 mm Hg) and walking durations (10 and 20 minutes), measuring PPP at specific foot locations.
  • Results showed significant differences in PPP at longer walking times, and it's recommended that individuals at risk of foot ulcers use 80 mm Hg insoles, avoiding stiffer ones for walks over 20 minutes.
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Narrow-bandgap (NBG) mixed tin/lead-based (Sn-Pb) perovskite solar cells (PSCs) have attracted extensive attention for use in tandem solar cells. However, they are still plagued by serious carrier recombination due to inferior film properties resulting from the alloying of Sn with Pb elements, which leads to p-type self-doping behaviors. This work reports an effective tin oxide (SnO ) doping strategy to produce high-quality Sn-Pb perovskite films for utilization in efficient single-junction and tandem PSCs.

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Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other therapeutic strategies. However, the current sonosensitizers used for SDT normally exhibit low activity for ultrasound (US)-induced reactive oxygen species (ROS) generation. Herein, the crystalline-to-amorphous phase transformation is reported as a simple but powerful strategy to engineer ultrathin 2D CoW-LDH and NiW-LDH nanosheets as highly efficient sonosensitizers for SDT.

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Background: Low back pain (LBP) can significantly affect a person's quality of life. Cupping has been used to treat LBP. However, various cupping methods are typically included in evaluating the efficacy of cupping therapy.

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Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets.

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Combining photodynamic therapy (PDT) with chemodynamic therapy (CDT) has been proven to be a promising strategy to improve the treatment efficiency of cancer, because of the synergistic therapeutic effect arising between the two modalities. Herein, we report an inorganic nanoagent based on ternary NiCoTi-layered double hydroxide (NiCoTi-LDH) nanosheets to realize highly efficient photodynamic/chemodynamic synergistic therapy. The NiCoTi-LDH nanosheets exhibit oxygen vacancy-promoted electron-hole separation and photogenerated hole-induced O-independent reactive oxygen species (ROS) generation under acidic circumstances, realizing pH-responsive PDT.

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Noninvasive tumor therapy requires a new generation of bionanomaterials towards sensitive response to the unique tumor microenvironment to achieve accurate and effective treatment. Herein, we have developed a tumor therapy nanoplatform by immobilizing natural glucose oxidase (GOD) onto Cu-based layered double hydroxide (CuFe-LDH) nanosheets, which for the first time integrates acid-enhanced photothermal therapy (PTT), and pH-responsive and heat-facilitated chemodynamic therapy (CDT) simultaneously. As demonstrated by EXAFS and HRTEM, CuFe-LDH nanosheets possess a considerable number of defects caused by different acid conditions, resulting in a significantly acid-enhanced photothermal conversion efficiency (83.

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Photodynamic therapy (PDT), a non-invasive therapeutic modality, has received increasing attention owing to its high selectivity and limited side effects. Although significant clinical research progress has been made in PDT, the breadth and depth of its clinical application have not been fully realized due to the limitations such as inadequate light penetration depth, non-targeting photosensitizers (PSs), and tumor hypoxia. Consequently, numerous investigations put their emphasis on innovative strategies to overcome the aforementioned limitations and enhance the therapeutic effect of PDT.

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