Effectiveness of an Online Medical Spanish Course in Improving Medical Students' Spanish Proficiency.

Introduction: A growing need exists for language-concordant healthcare for Spanish speakers in the United States. More than three-quarters of American medical schools provide Spanish language instruction, but little data exists on best practices. The purpose of this retrospective study was to examine whether an online medical Spanish course is effective at improving medical students' Spanish proficiency.

Algal Active Ingredients and Their Involvement in Managing Diabetic Mellitus.

Diabetes mellitus (DM) is becoming increasingly prominent, posing a serious threat to human health. Its prevalence is rising every year, and often affects young people. In the past few decades, research on marine algae has been recognized as a major field of drug discovery.

Visualization of Anion Vacancy Defect Annihilation in CZTSe Solar Cells by Hydrogen-Assisted Selenization with In Operando X-ray Nanoprobe Studies.

The traditional sulfur selenization process in CuZnSn(S,Se) (CZTSSe) solar cell fabrication often results in the creation of localized anion vacancies ( and ). These vacancies are considered harmful defects as they can trap carriers generated by light, leading to reduced solar cell efficiency. Moreover, concrete evidence has been lacking on the extent of the impact caused by these anion vacancies.

A multifunctional gingival retraction cord with antibacterial and hemostasis properties based on Chitosan/Propolis/Tranexamic acid for dental treatment.

A novel gingival retraction cord named P/TA@CSy was prepared using chitosan yarns (CSy) loaded with tranexamic acid (TA) and Propolis (P). P/TA@CSy has good toughness with a breaking strength of 41.3 Pa, benefiting from the twisting structure and Propolis coating.

Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization.

Selective activation of Pt(IV) prodrugs within tumors has emerged as a promising strategy in tumor treatment. Although progress has been made with photo- and ultrasound-activated Pt(IV) prodrugs, concerns remain over the non-specific activation of photosensitizers (PS) and the potential for phototoxicity and chemical toxicity. In this study, a sequential dual-locked Pt(IV) nano-prodrug that can be activated by both the acidic tumor microenvironment and light was developed.

Marine algae-derived characterized bioactive compounds as therapy for cancer: A review on their classification, mechanism of action, and future perspectives.

In 2022, there were around 20 million new cases and over 9.7 million cancer-related deaths worldwide. An increasing number of metabolites with anticancer activity in algae had been isolated and identified, which were promising candidates for cancer therapy.

Effectiveness of prognostic nutritional index in predicting overall survival and evaluating immunotherapy response in anaplastic thyroid carcinoma.

Background: The prognostic value of nutritional status in anaplastic thyroid carcinoma (ATC) remains unclear. The Prognostic Nutritional Index (PNI) is a reliable indicator of overall nutritional and immune status, and it has emerged as a significant prognostic factor in various malignancies. This study aimed to explore the utility of PNI in ATC.

Designing a superhydrophobic cotton fiber coating exploiting TiO@g-CN layered structure for augmented photocatalysis and efficient water-oil separation.

This study introduces a novel approach to develop a multifunctional coating on cotton fabric, emphasizing the utilization of cotton fiber as a biological macromolecule, by integrating a TiO@g-CN layered structure to confer superhydrophobic properties and multiple functionalities. The engineered structure not only enhances fabric roughness but also incorporates non-fluoro hydrophobic agents, thereby imparting diverse capabilities such as photocatalysis, oil-water separation, and self-cleaning to the cotton substrate. Fabrication of the TiO@g-CN layered structure involved ultrasonic dispersion of TiO and g-CN, subsequently deposited onto cotton fabric.

The association between Internet use and cognitive ability among rural left-behind children in China.

Introduction: This study focuses on the cognitive development of rural children aged 10-15 who have been left behind, utilizing data from the China Family Panel Studies (CFPS) datasets of 2016 and 2020. The primary objective is to investigate the correlation between Internet usage and the cognitive ability of these children.

Methods: An Ordinary Least Squares (OLS) regression model was initially employed to explore the potential influence of Internet use on the cognitive ability of rural left-behind children.

Solution blow spun bilayer chitosan/polylactic acid nanofibrous patch with antibacterial and anti-inflammatory properties for accelerating acne healing.

The quercetin (QC) loaded chitosan (CS) nanofibrous patch (CS) was designed and fabricated successfully by solution blow spinning (SBS). And it was employed to explore a functional double-layer nanofibrous patch (CS/PLA) with polylactic acid (PLA) for overcoming the resistance of acne-causing bacteria to antibiotics and local cutaneous irritation. The nanofibrous patch possessed a fluffy bilayer structure with good air permeability, which may be befitted from the SBS method.

The Contribution of the Internet to Promoting Mental Health for Older Adults: Cross-Sectional Survey in China.

Background: Health is an important topic for everyone and essential to high-quality economic and social development. Recently, some researchers have suggested that older adults' internet use may have a health effect.

Objective: This study specifically aims to clarify the relationship between internet use and the mental health of older adults, for which other surveys present contradictory results.

Photosynthetic System Based on a Polyoxometalate-Based Dehydrated Metal-Organic Framework for Nitrogen Fixation.

In nature, biological nitrogen fixation is accomplished through the π-back-bonding mechanism of nitrogenase, which poses significant challenges for mimic artificial systems, thanks to the activation barrier associated with the N≡N bond. Consequently, this motivates us to develop efficient and reusable photocatalysts for artificial nitrogen fixation under mild conditions. We employ a charge-assisted self-assembly process toward encapsulating one polyoxometalate (POM) within a dehydrated Zr-based metal-organic framework (d-UiO-66) exhibiting nitrogen photofixation activities, thereby constructing an enzyme-mimicking photocatalyst.

Cotton fiber-based dressings with wireless electrical stimulation and antibacterial activity for wound repair.

Although cotton dressing is one of the most commonly used wound management materials, it lacks antimicrobial and healing-promoting activity. This work developed a multilayer electroactive composite cotton dressing (Ag/Zn@Cotton/Paraffin) with exudate-activated electrical stimulation and antibacterial activity by the green and sustainable magnetron-sputtering and spraying methods. The inner hydrophilic layer of the cotton dressing was magnetron sputtered with silver/zinc galvanic couple arrays (Ag/Zn), which can be activated by wound exudate, generating an electrical stimulation (ES) into the wound.

The contribution of audiobook use on the mental health of older adults: the mediating effects of social adaptation.

This study aims to examine the association between audiobook use and the mental health of older adults. Data were from the 2018 China Longitudinal Aging Social Survey(CLASS 2018). The study utilized multiple linear regression to examine the association between audiobook use and the mental health of older adults.

Self-Assembly of Polyoxometalate-Based Sub-1 nm Polyhedral Building Blocks into Rhombic Dodecahedral Superstructures.

Self-assembly of subnanometer (sub-1 nm) scale polyhedral building blocks can yield some superstructures with novel and interesting morphology as well as potential functionalities. However, achieving the self-assembly of sub-1 nm polyhedral building blocks is still a great challenge. Herein, through encapsulating the titanium-substituted polyoxometalate (POM, K PTi W O ) with tetrabutylammonium cations (TBA ), we first synthesized a sub-1 nm rhombic dodecahedral building block by further tailoring the spatial distribution of TBA on the POM.

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology.

The polymorphic microbiome has been proposed as a new hallmark of cancer. Intratumor microbiome has been revealed to play vital roles in regulating tumor initiation and progression, but the regulatory mechanisms have not been fully uncovered. In this review, we illustrated that similar to other components in the tumor microenvironment, the reside and composition of intratumor microbiome are regulated by tumor cells and the surrounding microenvironment.

Ce-mediated molecular tailoring on gigantic polyoxometalate {Mo} into half-closed {CeMo} for high proton conduction.

Precise synthesis of polyoxometalates (POMs) is important for the fundamental understanding of the relationship between the structure and function of each building motif. However, it is a great challenge to realize the atomic-level tailoring of specific sites in POMs without altering the major framework. Herein, we report the case of Ce-mediated molecular tailoring on gigantic {Mo}, which has a closed structural motif involving a never seen {Mo} decamer.

4'-(8-(4-Methylimidazole)-octyloxy)-arctigenin: The first inhibitor of fish rhabdovirus glycoprotein.

Spring viraemia of carp virus (SVCV), a highly pathogenic rhabdovirus, could cause spring viraemia of carp (SVC) with up to 90% lethality. Like other rhabdoviruses, the entry of SVCV into susceptible cells was mediated by a single envelope glycoprotein G. Specific inhibitors targeting the glycoprotein were the most effective means to alleviate the epidemic.

Acquire, Curate, Diversify: Staying Current With Key Medical Education Literature.

Rapid technological advancement has led to increasingly convenient and affordable access to academic publications while also contributing to information overload.We recommend the following strategies for clinicians and researchers to effectively stay current with themedical education literaturemost applicable to their areas of focus. 1,2.

The effects of using Tempeh as a supplement for type 2 diabetes.

Studies suggest that the consumption of Tempeh can improve abnormal blood glucose and lipid parameters, although it remains still unclear as to whether Tempeh can improve tissue damage. In our study, db/db obese diabetic mice were given Tempeh 1 (300 mg/kg) and Tempeh 2 (600 mg/kg) for 3 months. The tissue samples collected were stained using different tissue-staining methodologies and were compared with the diabetic control group that was not given any Tempeh.

Photochemical Ammonia Synthesis over Reduced Polyoxovanadate-Intercalated Defective ZnAl Layered Double Hydroxide Nanosheets.

The exploration of efficient and stable N fixation photocatalysts featuring a broad absorption spectrum and N fixation active sites has become specifically conspicuous. Herein, a series of reduced polyoxovanadates (POVs) were intercalated into copper-induced ZnAl layered double hydroxide (0.5%-ZnAl LDH) nanosheets with oxygen vacancies via an anion exchange strategy toward green ammonia production.

The contribution of the smartphone use to reducing depressive symptoms of Chinese older adults: The mediating effect of social participation.

Background: Depression is a prevalent mental health disorder. Although Internet use has been associated with depression, there is limited data on the association between smartphone use and depressive symptoms. The present study aimed to investigate the relationship between smartphone use and depressive symptoms among older individuals in China.

Applying TEC-VARIETY to Motivate and Engage Learners for Online Learning Success.

Learner motivation plays an essential role in overcoming barriers to achieve online learning success. Many health professions educators, however, are not familiar with evidence-based motivational principles and techniques that tap into learners' inner resources to promote online learning success. The TEC-VARIETY (T-Tone; E-Encouragement; C-Curiosity; V-Variety; A-Autonomy; R-Relevance; I-Interactivity; E-Engagement; T-Tension; and Y-Yielding products) framework provides evidence-based principles and techniques that motivate and engage learners.