A longitudinal study of self-report tooth loss impacting functional status among Chinese older adults: moderated mediation of social relationships and psychological resilience.

Objectives: This study aimed to discern the longitudinal association between tooth loss and subsequent functional status, specifically investigating the moderated mediation effects of social relationships and psychological resilience.

Methods: Data from the 2011, 2014, and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were analyzed, we included 2,834 older adults aged 65 and over in the study. The longitudinal relationship between tooth loss and functional status was analyzed using the generalized estimating equation.

Social participation, subjective well-being, and cognitive function as serial mediators between tooth loss and functional limitations in older Chinese adults.

Background: Although tooth loss appears to be related to functional limitations, the mechanisms that underpin this relationship are unknown. We sought to address this knowledge gap by examining a multiple mediation hypothesis whereby tooth loss is predicted to indirectly affect functional limitations through social participation, subjective well-being, and cognitive function.

Methods: This study included 7,629 Chinese adults from the 2017/2018 Chinese Longitudinal Healthy Longevity Survey wave.

SLC10A3 Is a Prognostic Biomarker and Involved in Immune Infiltration and Programmed Cell Death in Lower Grade Glioma.

Background: The association between SLC10A3 (solute carrier family 10 member 3) and lower grade glioma (LGG) remains unclear.

Methods: We used public databases and bioinformatics analysis to analyze SLC10A3. These included The Cancer Genome Atlas, Genotype-Tissue Expansion, Chinese Glioma Genome Atlas, Human Protein Atlas, GeneCards, cBioPortal, Search Tool for the Retrieval of Interacting Genes/Proteins, Gene Expression Profiling Interactive Analysis, Tumor Immune Estimation Resource, Tumor-Immune System Interaction Database, receiver operating characteristic curve analysis, Kaplan-Meier analysis, Cox analysis, nomograms, calibration plots, gene ontology/Kyoto Encyclopedia of Genes and Genomes enrichment analysis, gene set enrichment analysis, single-sample gene set enrichment analysis, and Spearman's correlation analysis.

Longitudinal associations between social relationships and cognitive function among Chinese older adults: The mediating role of healthy lifestyles.

Background: We aimed to explore whether social relationships and cognitive function were reciprocally related and whether healthy lifestyles mediate their association.

Methods: This study included 3372 Chinese adults from the years 2014-2018 wave of the Chinese Longitudinal Healthy Longevity Survey.

Results: Baseline social relationships were negatively associated with a change in cognitive function (β = -0.

Retraction Notice to: UPL5 modulates WHY2 protein distribution in a Kub-site dependent ubiquitination in response to [Ca]-induced leaf senescence.

[This retracts the article DOI: 10.1016/j.isci.

UPL5 modulates WHY2 protein distribution in a Kub-site dependent ubiquitination in response to [Ca]-induced leaf senescence.

The translocation of proteins between various compartments of cells is the simplest and most direct way of an/retrograde communication. However, the mechanism of protein trafficking is far understood. In this study, we showed that the alteration of WHY2 protein abundance in various compartments of cells was dependent on a HECT-type ubiquitin E3 ligase UPL5 interacting with WHY2 in the cytoplasm, plastid, and nucleus, as well as mitochondrion to selectively ubiquitinate various Kub-sites (Kub 45 and Kub 227) of WHY2.

Whole Genome Resequencing Revealed the Effect of Helicase Gene on Regulating LLP29 against Ultraviolet Radiation Stress.

(Bt) is a widely used microbial pesticide. However, its duration of effectiveness is greatly shortened due to the irradiation of ultraviolet rays, which seriously hinders the application of Bt preparations. Therefore, it is of great importance to study the resistance mechanism of Bt to UV at the molecular level to improve the UV-resistance of Bt strains.

[Mechanism of Impaired Cognitive Function in Patients with Chronic Kidney Disease].

Each stage of chronic kidney disease has a high risk of cognitive dysfunction.The decline of cognitive function will affect the daily life and treatment compliance of the patients with chronic kidney disease and increase the patients' risk of death and public health burden,which has aroused widespread concern.However,the specific mechanism of cognitive impairment in the patients with chronic kidney disease remains unclear.

[Poor Oral Health and Sarcopenia in the Elderly:a Review of Their Correlation and Intervention Measures].

Sarcopenia is a common geriatric syndrome associated with the occurrence of adverse consequences such as falls,debility,and death,seriously affectingthe quality of life of the elderly.Oral health as the basis of the overall health plays a vital role in improving the overall quality of life and extending the healthy life span of the elderly.Studies have demonstrated that poor oral health may increase the risk of sarcopenia.

Association between frailty and cognitive function in older Chinese people: A moderated mediation of social relationships and depressive symptoms.

Background: To date, few studies have focused on examining either the direct or indirect effect of physical frailty on cognitive impairment. This study aimed to investigate the moderating effects of social relationships, including their individual components in the role of depressive symptoms as a mediator between frailty and cognitive impairment.

Methods: This study included a total of 7525 Chinese older adults from the 2017-2018 wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Relationship between tooth loss and sarcopenia in suburban community-dwelling older adults in Shanghai and Tianjin of China.

Both sarcopenia and loss of teeth are associated with aging. The purpose of this study was to investigate potential relationships between tooth loss and sarcopenia and its components in suburban community-dwelling older adults of Shanghai and Tianjin, China. The subjects were 1494 people over 60 years of age (40.

WHIRLY1 recruits the histone deacetylase HDA15 repressing leaf senescence and flowering in Arabidopsis.

Leaf senescence is controlled by a complex regulatory network in which robustness is ensured by the activity of transcription factors and epigenetic regulators. However, how these coordinate the process of leaf senescence remains poorly understood. We found that WHIRLY1 interacts with Histone Deacetylase (HDA)15, a Reduced Potassium Dependence3 (RPD3)/HDA1-type HDA, by using green fluorescent protein-nanotrap-mass spectrum assays.

Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.

Background: Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators.

Objectives: This study aimed to investigate the relationship between obesity-related indicators and cognitive impairment, especially between different age or gender subgroups, and explore whether obesity-related indicators were related to specific cognitive domains.

Methods: This was a cross-sectional study on 1753 participants aged ≥ 60 years (41.

Gender-specific associations of speech-frequency hearing loss, high-frequency hearing loss, and cognitive impairment among older community dwellers in China.

Background And Aims: This study aimed atinvestigating the relationship between speech-frequency hearing loss (SFHL), high-frequency hearing loss (HFHL), and cognitive impairment (CI) and then to determine whether there are any differences in gender among older community dwellers in China.

Methods: 1012 adults aged ≥ 60 years (428 males; average age, 72.61 ± 5.

Long Sleep Duration Associated With Cognitive Impairment in Chinese Community-Dwelling Older Adults.

We aimed to examine the association between sleep duration and impaired cognitive function in different cognitive domains in Chinese community-dwelling older adults. A total of 1591 participants (≥60 years) were divided into five groups: ≤6 hours (very short sleep duration), >6 to 7 hours (short sleep duration), ≥7 to 8 hours (moderate sleep duration), >8 to 9 hours (moderately long sleep duration), and >9 hours (long sleep duration), according to sleep duration. Cognitive function was assessed using the Mini-Mental State Examination.

Mediating effects of lower extremity function on the relationship between night sleep duration and cardiovascular disease risk: a cross-sectional study in elderly Chinese without cardiovascular diseases.

Objective: The purpose of this study is to investigate the mediating effect of physical performance on the relationship between night sleep duration and risk of cardiovascular disease (CVD) in elderly Chinese without CVD.

Methods: 782 participants without CVD over 65 years (average: 70.82±3.

Obesity, Even in the Metabolically Healthy, Increases the Risk of Poor Physical Performance: A Cross-Sectional Study of Older People in a Chinese Community.

Objective: We examined the association between obesity and physical performance under different metabolic status.

Methods: The sample included 1395 Chinese community-dwelling participants (mean age, 71.88 ± 5.

Effect of mobile health based peripartum management of gestational diabetes mellitus on postpartum diabetes: A randomized controlled trial.

Aims: To investigate the effects of mobile health based peripartum management of gestational diabetes mellitus (GDM) on postpartum diabetes and factors associated with postpartum diabetes.

Methods: Women with GDM (n = 309) were randomly assigned to receive standard management (SM) or mobile management (MM). 75-g OGTT was performed at 6 weeks postpartum.

Relationship Between Physical Performance and Mild Cognitive Impairment in Chinese Community-Dwelling Older Adults.

Objective: This study aimed to examine the relationship between physical performance and mild cognitive impairment (MCI) in Chinese older adults.

Methods: The sample comprised 956 relatively healthy and aged ≥65 years old Chinese community-dwelling participants (mean age, 72.56 ± 5.

Combined effect of obesity and low physical performance on the incidence of hypertension in Chinese community-dwelling older population.

The combination of having a low physical performance and obesity results in a vicious cycle, but the effect of this combination on the incidence of hypertension is still unknown. This article aims to examine the effect of obesity and low physical performance on the incidence of hypertension in older adults. The sample was comprised of 349 Chinese community-dwelling participants (199 women; mean age 66.

Degradable calcium deficient hydroxyapatite/poly(lactic-glycolic acid copolymer) bilayer scaffold through integral molding 3D printing for bone defect repair.

A novel method was developed for calcium deficient hydroxyapatite (CDHA) scaffold 3D printing, through which a bilayer scaffold was fabricated by the integral molding of individual CDHA and poly(lactic-glycolic acid copolymer) (PLGA). The hydration reaction of-tricalcium phosphate (TCP) was utilized to form CDHA, and a mixed solution of gelatin, glycerine and glutaraldehyde was applied as the dispersant and adhesive. The concentration of the glutaraldehyde (1‰(v/v)) and the mixing ratio of-TCP (0.

Glycemic qualification rate and frequency of self-monitoring blood glucose glycemic qualification rate and frequency of self-monitoring blood glucose (SMBG) in women with gestational diabetes mellitus (GDM).

Aims: To explore the relationship between blood glucose (BG) control rate and self-monitoring blood glucose (SMBG) compliance of women with gestational diabetes mellitus (GDM).

Methods: Women with GDM (n = 309) were randomized to receive routine clinical prenatal care or additional online management. Follow-up visits were conducted every two weeks (noted here as T) from enrollment to delivery.