Multi-functional PEEK implants enhance osseointegration in OVX rat by remodeling the bone immune microenvironment.

Osseointegration is significantly impeded in osteoporotic conditions due to the elevated levels of reactive oxygen species (ROS) and inflammation at the site of injury. To enhance bone regeneration in osteoporotic conditions, a modified polyether ether ketone (PEEK) implants was prepared, denoted as PEEK-PDA-Sr. The implants consisted of mussel adhesion layer with the conjugation of strontium (Sr) ions, which can constantly release Sr ions for up to 3 weeks.

Myogenic differentiation of human amniotic mesenchymal cells and its tissue repair capacity on volumetric muscle loss.

Stem cell-based tissue engineering therapy is the most promising method for treating volumetric muscle loss. Human amniotic mesenchymal cells possess characteristics similar to those of embryonic stem cells. In this study, we verified the stem cell characteristics of human amniotic mesenchymal cells by the flow cytometry analysis, and osteogenic and adipogenic differentiation.

Biosynthesis of Silver nanoparticles using Bauhinia acuminate flower extract and their effect to promote osteogenesis of MSCs and improve meniscus injury healing.

The latent utilization of biomaterials that are osteo-conducive in the advancement of healing bone fracture has fascinated extensive consideration. This work includes the synthesis of silver nanoparticles (AgNPs) with the help of a Bauhinia acuminate plant flower extract through an ecofriendly synthetic process without any use of harmful reductants. In the fabrication of AgNPs, Bauhinia acuminate plant flower extract bio constituents acts as both stabilizing and reducing agent.

Cucurbita pepo leaf extract induced synthesis of zinc oxide nanoparticles, characterization for the treatment of femoral fracture.

The present work showed the green, eco-friendly synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Cucurbita pepo. The prepared ZnO NPs were studied using different characterization techniques such as Fourier transform infrared (FTIR), X-ray diffraction (XRD), UV-Visible spectroscopy (UV-Vis) and Transmission electron microscopy (TEM). TEM images confirmed the formation of NPs with average size of 8 nm.

Fibroblast growth factor type 1 receptor stimulation of T-type Ca channels in sensory neurons requires the phosphatidylinositol 3-kinase and protein kinase A pathways, independently of Akt.

Fibroblast growth factor-23 (FGF-23) secreted by osteocytes is known as a circulating factor that is essential for phosphate homeostasis. Recent studies have implicated FGF-23 in the nociceptive signalling of peripheral sensory neurons. However, the relevant mechanisms underlying this effect are not known.