Inhibition of aldose reductase ameliorates ethanol‑induced steatosis in HepG2 cells.

Aldose reductase (AR) expression is increased in liver tissue of patients with ethanol‑induced liver disease. However, the exact role of AR in the development of ethanol‑induced liver disease has yet to be elucidated. The present study aimed to determine the effect of an AR inhibitor on ethanol‑induced steatosis in HepG2 cells and to identify possible underlying molecular mechanisms.

Brominated flame retardants in the hair and serum samples from an e-waste recycling area in southeastern China: the possibility of using hair for biomonitoring.

Hair samples and paired serum samples were collected from e-waste and urban areas in Wenling of Zhejiang Province, China. The PBDE and DBDPE concentrations in hair and serum samples from e-waste workers were significantly higher than those of non-occupational residents and urban residents. BDE209 was the dominating BFRs in hair and serum samples from the e-waste area, while DBDPE was the major BFRs from the urban area.

Levels, distributions and correlations of polybrominated diphenyl ethers in air and dust of household and workplace in Shanghai, China: implication for daily human exposure.

Polybrominated diphenyl ethers (PBDEs) were measured in air (TSP and PM2.5) and dust samples collected from 16 households and the corresponding workplaces of eight volunteer citizens in Shanghai, China. The PBDEs concentrations in the workplace air (mean: 281 ± 126 pg m(-3)) were over two times higher than those in the household (121 ± 44.

Polybrominated diphenyl ethers in resident Eurasian Tree Sparrow from Shanghai: geographical distribution and implication for potential sources.

An investigation of polybrominated diphenyl ethers (PBDEs) in Eurasian Tree Sparrow (Passer montanus) samples (n=37) collected from different land use areas in Shanghai provided information about the levels, compositional patterns, geographical distribution, potential sources of PBDEs and the evaluation of contamination status in Shanghai. The concentrations of BDE 209 and Sum-PBDEs were within the range of 8.20-292.

Upregulation of activator protein-4 in human colorectal cancer with metastasis.

The aim of this study is to investigate the expression of AP-4, VEGF, and MMP-9 genes in human colorectal cancer. The expression pattern of activator protein-4 in 160 colorectal cancer compared with 32 colorectal adenomas and 32 normal colorectal tissues is demonstrated by tissue microarray-immunohistochemistry and real-time reverse transcriptase-polymerase chain reaction. Apoptosis status using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling by comparing activator protein-4 positive versus activator protein-4 negative colorectal cancer is also assessed.

Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer.

The fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in the carcinogenesis of many human tissues, including digestive tract tissues. However, the expression and the role of the FHIT in the initiation and the development of the colorectal cancer (CRC) are poorly understood.

Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication.

Fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in carcinogenesis of many human tissues, including digestive tract tissues. However, the expression and role of FHIT in the initiation and the development of the colorectal cancer (CRC) are poorly understood.