Ferroelectric Optical Memristors Enabled by Non-Volatile Electro-Optic Effect.

Memristors enable non-volatile memory and neuromorphic computing. Optical memristors are the fundamental element for programmable photonic integrated circuits due to their high-bandwidth computing, low crosstalk, and minimal power consumption. Here, an optical memristor enabled by a non-volatile electro-optic (EO) effect, where refractive index modulation under zero field is realized by deliberate control of domain alignment in the ferroelectric material Pb(MgNb)O-PbTiO(PMN-PT) is proposed.

The modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells.

Ion channels play a crucial role in cardiac functions, and their activities exhibit dynamic changes during heart development. However, the precise function of ion channels in human heart development remains elusive. In this study, we utilized human embryonic stem cells (hESCs) as a model to mimic the process of human embryonic heart development.

Exosome isolation based on polyethylene glycol (PEG): a review.

Exosome acts as an outstanding biomarker for ongoing studies, diagnosis and prognosis of multiples diseases. Therefore, the call for economically and efficiently isolating a large number of exosomes is an active area of investigation. However, to date, the challenges including complex isolated procedure, uneconomical equipment, low protein content and distinct loss in the particle number of exosomes etc.

Air pollution exposure and prevalence of non-alcoholic fatty liver disease and related cirrhosis: A systematic review and meta-analysis.

Background And Objective: A systematic review and meta-analysis were used to investigate the relationship between air pollution exposure and the prevalence of non-alcoholic fatty liver disease (NAFLD) and its related cirrhosis. Through this study, we hope to clarify the potential public health risks of air pollution as an environmental exposure factor.

Methods: Through a comprehensive and systematic search of the EMBASE, PubMed, Web of Science, and Cochrane library databases, studies published up to March 30, 2024, that met the eligibility criteria were identified.

The miR-6240 target gene Igf2bp3 promotes myoblast fusion by enhancing myomaker mRNA stability.

Background: Myoblast fusion plays a crucial role in myogenesis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) functions as an RNA N-methyladenosine reader and exerts important roles in various biological processes. While our prior study suggested Igf2bp3 contributes to myogenesis, its molecular regulatory mechanism is largely unclear.

Nonlinear photonics on integrated platforms.

Nonlinear photonics has unveiled new avenues for applications in metrology, spectroscopy, and optical communications. Recently, there has been a surge of interest in integrated platforms, attributed to their fundamental benefits, including compatibility with complementary metal-oxide semiconductor (CMOS) processes, reduced power consumption, compactness, and cost-effectiveness. This paper provides a comprehensive review of the key nonlinear effects and material properties utilized in integrated platforms.

Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management.

: Ferroptosis in lung epithelium and endothelium contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), a critical and often fatal condition marked by acute inflammation and elevated pulmonary vascular permeability. Despite this, there are currently no FDA-approved therapeutics specifically targeting ferroptosis for ARDS management. : A screening of 259 FDA-approved drugs was conducted to identify an effective ferroptosis inhibitor in pulmonary epithelial and endothelial cells.

Effects of temporal, spatial, and environmental factors on ciliates community in northeastern South China Sea, with notes on co-occurrence patterns of environment, phytoplankton, and ciliate.

Unlabelled: Little is known about temp-spatial variations and determining mechanism of microplankton community from continental shelf to deep basin. Here, the distribution and determinants of ciliates in the northeastern South China Sea were investigated in summer and winter. We found that the alpha diversity were generally similar, but community composition showed clear difference in summer and winter.

Comparative Analysis of the Morphological Traits of Cucumis melo Seed Remains Discovered in the Graveyard of the Haihun Marquis in Nanchang and Modern C. melo Seeds Using Scanning Electron Microscopy.

The graveyard of the Haihun Marquis in Nanchang is the largest and best-preserved Han Dynasty mausoleum discovered in China. Within the tomb's beam bank (M1), archaeologists have uncovered a variety of plant remains, such as melon seeds, the traits and origins of which warrant timely investigation. Cucumis melo L.

Comparative and Spatial Transcriptome Analysis of Franch. During the Flowering Period and Revelation of the Plant Defense Mechanism.

Background: is a globally distributed and extensive genus, comprising over 1000 species. In the southwestern mountains of China, there exists a remarkable diversity of , with Yunnan Province alone harboring more than 600 species. Franch.

Less-Lethal Weapons and Civilian Injury in Police Use of Force Encounters: A Multi-agency Analysis.

Police use-of-force is a growing public health concern, with recent estimates suggesting that over 70,000 people are injured by police each year. To reduce the risk of injury to civilians, most police agencies authorize the use of various less-lethal weapons. However, to date, there is little consensus as to which types of less-lethal weapons are most effective at reducing injury risk.

Creeping Fat-Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn's Disease.

Background & Aims: In Crohn's disease, wrapping of mesenteric fat around the bowel wall, so-called "creeping fat," is highly associated with strictures. The strongest contributor to luminal narrowing in strictures is a thickening of the human intestinal muscularis propria (MP). We investigated creeping fat-derived factors and their effect on mechanisms of human intestinal MP smooth muscle cell (HIMC) hyperplasia.

The Spatial-Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis.

Alternative splicing (AS) is a fundamental mechanism contributing to proteome diversity, yet its comprehensive landscape and regulatory dynamics during skeletal muscle development remain largely unexplored. Here, the temporal AS profiles are investigated during myogenesis in five vertebrates, conducting comprehensive profiling across 27 developmental stages in skeletal muscle and encompassing ten tissues in adult pigs. The analysis reveals a pervasive and evolutionarily conserved pattern of alternative exon usage throughout myogenic differentiation, with hundreds of skipped exons (SEs) showing developmental regulation, particularly within skeletal muscle.

Juvenile hormone as a key regulator for asymmetric caste differentiation in ants.

Caste differentiation involves many functional traits that diverge during larval growth and metamorphosis to produce adults irreversibly adapted to reproductive division of labor. Investigating developmental differentiation is important for general biological understanding and has increasingly been explored for social phenotypes that diverge in parallel from similar genotypes. Here, we use ants to investigate the extent to which canalized worker development can be shifted toward gyne (virgin-queen) phenotypes by juvenile hormone (JH) treatment.

The aeration and dredging stimulate the reduction of pollution and carbon emissions in a sediment microcosm study.

Sediment dredging and aeration are used as important technical measures to remediate internal loading of sediment in polluted rivers. However, previous studies have overlooked the impact of dredging and aeration on Greenhouse gases (GHGs) emission. We established three aeration rate(six different aeration intervals), one dredging treatment to investigate the effect of aeration and dredging on pollutant removals and CO, CH and NO emissions.

In-tunnel pollutant concentration measurement and ventilation control indexes for highway tunnels in mountainous area: A case study of no.1 Qinling tunnel, China.

The pollutant concentration and hygiene standards in mountain tunnels are key factors determining the ventilation effectiveness of tunnel operation. Previous studies have mainly focused on the spatiotemporal distribution patterns of in-tunnel pollutants, while research on ventilation control indexes for pollutants in long mountain tunnels are relatively limited. Therefore, this paper aims to discussing the hygiene control indexes for operational ventilation of mountain tunnels.

Simultaneous CO and biogas slurry treatment using a newly isolated microalga with high CO tolerance.

The fixation of carbon dioxide (CO) using microalgae is a promising CO capture and utilization technology. Microalgae have also been suggested as a potential treatment for biogas slurry (BS). This study screened microalgae capable of tolerating both high CO concentrations and BS, assessed their CO fixation and pollutant removal capabilities, and evaluated the potential use of the resulting algal biomass.

Dual-activity nanozyme as an oxygen pump to alleviate tumor hypoxia and enhance photodynamic/ NIR-II photothermal therapy for sniping oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region, and its treatment is limited by hypoxia and inadequate oxygen supply. Continuous oxygen delivery combined with photodynamic therapy (PDT) is the key to addressing this issue. Here, a dual-enzyme activity sea urchin-like Au@Pt-Ce6-HN-1 nanoplatform was designed to serve as an "oxygen pump" to alleviate tumor hypoxia for synergistic photodynamic/photothermal therapy (PTT).

Integrin β1 in breast cancer: mechanisms of progression and therapy.

The therapy for breast cancer (BC), to date, still needs improvement. Apart from traditional therapy methods, biological therapy being explored opens up a novel avenue for BC patients. Integrin β1 (ITGβ1), one of the largest subgroups in integrin family, is a key player in cancer evolution and therapy.

Drug or Toxic? A Brief Understanding of the Edible Corolla of Franch. by Bai Nationality with Comparative Metabolomics Analysis.

is a traditional ornamental and medicinal plant in China, renowned for its aesthetic appeal and therapeutic properties. Regarding Franch., mainly distributed in Yunnan Province, its corolla is regarded as an edible food by the Bai ethnic group in Yunnan Province.