Teacher competency and work engagement among secondary school physical education teachers: the multiple mediating roles of occupational stress, emotional exhaustion, and professional achievement.

Objective: This study examined the relationships between teacher competency, occupational stress, emotional exhaustion, sense of professional achievement, and work engagement among secondary school physical education teachers. It also investigated demographic differences in these variables and tested the structural invariance of the proposed model across genders.

Method: A total of 1,347 secondary school physical education teachers participated in the study, completing validated scales to measure the key constructs and providing demographic information such as gender, age, education level, professional title, and school location.

Baricitinib treatment for hospitalized patients with severe COVID-19 on invasive mechanical ventilation: a propensity score-matched and retrospective analysis.

Introduction: Baricitinib is a selective inhibitor of Janus kinase (JAK)1 and JAK2, which is associated with clinical improvement in non-severe COVID-19 patients. But in severe COVID-19 patients, the effectiveness of baricitinib is still controversial.

Methods: A propensity score-matched and retrospective study was conducted to evaluate the effectiveness of baricitinib in severe COVID-19 patients requiring invasive mechanical ventilation (IMV).

A study on the relationship between physical exercise and feelings of inferiority among college students: the chain mediating effect of social support and emotional regulation ability.

Objective: This study aims to explore the impact of physical exercise on feelings of inferiority among college students, focusing on the mediating roles of social support and emotional regulation ability. The research investigates both direct and indirect pathways to understand how physical exercise enhances psychological resilience and mitigates negative self-perceptions.

Methods: A sample of 2,036 college students from 15 provinces in China was surveyed using validated scales for physical exercise, feelings of inferiority, social support, and emotional regulation ability.

Unpacking the relationship between adolescents' perceived school climate and negative emotions: the chain mediating roles of school belonging and social avoidance and distress.

Objective: Guided by Self-System Processes Theory, Social Support Theory, and Stress and Coping Theory, this study investigates how perceived school climate influences adolescents' negative emotions through the chain mediation of school belonging and social avoidance and distress. It also examines demographic differences across gender and grade and tests the structural invariance of the proposed model.

Method: A cross-sectional survey of 1,507 Chinese adolescents in grades 5-9 was conducted using validated scales.

The relationship between urban residents' physical exercise attitudes and sports consumption demands: the mediating role of physical activity level.

Object: This study examines the differences and relationships among urban residents' physical exercise attitudes, physical activity levels, and sports consumption demands, focusing on how physical activity mediates the relationship between exercise attitudes and consumption behaviors.

Method: A survey was conducted among residents in Chengdu using validated questionnaires to measure physical exercise attitudes, physical activity levels, and sports consumption demands. Data analysis included independent samples t-tests and one-way ANOVA to assess differences across demographic variables, as well as correlation analysis and structural equation modeling to examine the path relationships among key variables.

Ten-month comprehensive assessment of steroid hormones in the tributaries of Baiyun District, Guangzhou City, China: Spatiotemporal dynamics, source attribution, and environmental implications.

The occurrence of steroid hormones in small river ecosystems raises environmental alarms due to their limited dilution capacity, heightened susceptibility to diverse pollution sources, and their substantial contribution to the contamination of larger river systems. Here, we investigated the occurrence of 40 steroid hormones over 10 months in 10 first-order tributaries (n = 250) of Guangzhou City, China. The observed concentrations of Σsteroid hormones ranged from 30.

Research on the relationship between physical literacy and demographic variables and interpersonal support for physical exercise among adolescents in China.

In recent decades, the concept of "Physical Literacy" has emerged as a significant breakthrough in enhancing the physical health of children and adolescents. This concept has become the guiding principle and future direction for physical education reform in Western countries. As China's economic and social development enters a new phase, the negative impact of insufficient physical activity on adolescent health remains a significant challenge to the strategies of "Healthy China" and "A Leading Sports Nation.

Effect on Non-Small Cell Lung Cancer after Combination of Driver Gene Mutations and Anti-PD-1/PD-L1 Immunotherapy as Well as Chemotherapy.

Background: We aimed to reveal the correlation between pathological indicators and PD-L1, between gene mutation status in lung cancer through clinico-pathological data and lung cancer-related gene mutation and PD-L1 expression analysis.

Methods: The study was conducted in Jinhua Municipal Central Hospital, Zhejiang, China from 2017 to 2022. PD-L1 testing and targeted gene mutations detection were evaluated.

Computer-assisted discovery and evaluation of potential ribosomal protein S6 kinase beta 2 inhibitors.

S6K2 is an important protein in mTOR signaling pathway and cancer. To identify potential S6K2 inhibitors for mTOR pathway treatment, a virtual screening of 1,575,957 active molecules was performed using PLANET, AutoDock GPU, and AutoDock Vina, with their classification abilities compared. The MM/PB(GB)SA method was used to identify four compounds with the strongest binding energies.

Sustained-release nitrate combined with microbial fuel cell: A novel strategy for PAHs and odor removal from sediment.

Nitrate addition is a biostimulation technique that can improve both the oxidation of acid volatile sulfide (AVS) through autotrophic denitrification and the biodegradation of polycyclic aromatic hydrocarbons (PAHs) via heterotrophic denitrification. However, during the remediation, parts of the dissolved nitrate in the sediment migrates from the sediment to the overlying water, leading to the loss of effective electron acceptor. To overcome this limitation, a combined approached was proposed, which involved nitrocellulose addition and a microbial fuel cell (MFC).

Occurrence and spatiotemporal distribution of PAHs and OPAHs in urban agricultural soils from Guangzhou City, China.

The occurrence of polycyclic aromatic hydrocarbon (PAH) derivatives in the environment is of growing concern because they exhibit higher toxicity than their parent PAHs. This study evaluated the large-scale occurrence and spatiotemporal distribution of 16 PAHs and 14 oxygenated PAHs (OPAHs) in urban agricultural soils from seven districts of Guangzhou City, China. Linear correlation analysis was conducted to explore the relationship between PAH and OPAH occurrence and a series of parameters.

Biotransformation kinetics and pathways of typical synthetic progestins in soil microcosms.

Gestodene (GES), altrenogest (ALT), and medroxyprogesterone acetate (MPA) are three potent synthetic progestins detected in agricultural soils; however, their biotransformation outcomes in soils remain unclear. This study explored the biotransformation of these progestins in five agricultural soils with different physicochemical properties. The biotransformation data were well-described by a first-order decay model (R = 0.

The clinical application value of compound Stachys sieboldii Miq granules to stable COPD patients.

Background: The aim of this paper was to explore the application value of Stachys sieboldii Miq granules which is a kind of traditional Chinese medicine (TCM) in stable chronic obstructive pulmonary disease (COPD) patients.

Methods: Randomized double-blind method was used to select 160 patients with stable COPD. The patients were randomly divided into placebo group and Stachys sieboldii Miq group.

Predictive model for the diagnosis of benign/malignant small pulmonary nodules.

There is some doubt that all nodules <8 mm are really mainly benign and that simple follow-up is adequate in all cases. The purpose of this study is to create a predictive model for the diagnosis of benign and malignant small pulmonary nodules.This was a retrospective case-control study of patients who had undergone pulmonary nodule resection at the Zhejiang University Jinhua Hospital.

Decision-making in primary onset middle-age type 2 diabetes mellitus: a BOLD-fMRI study.

Although type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for dementia, the neural mechanisms that underlying cognitive impairment in T2DM remain unclear. We used functional magnetic resonance imaging (fMRI) during a computerized version of the Iowa Gambling Task to investigate the neural basis of decision making at the initial onset stage of T2DM. Eighteen newly diagnosed middle-aged T2DM patients, with no previous diabetic treatment history, and 18 matched controls were recruited.

miR-32 functions as a tumor suppressor and directly targets SOX9 in human non-small cell lung cancer.

Purpose: MicroRNA-32 (miR-32) is dysregulated in certain human malignancies and correlates with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Thus, the aim of this study was to explore the effects of miR-32 expression on NSCLC tumorigenesis and development.

Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients.

Background: MicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-224 in NSCLC tumorigenesis and development.

Single frequency sound propagation in flat waveguides with locally reactive impedance boundaries.

A coherent image source method is presented for evaluating single frequency sound propagation from a point source in a flat waveguide with two infinite and parallel locally reactive boundaries. The method starts from formulating reflections of the spherical sound radiation into integrals of plane wave expansion, and the analytical evaluation of the integrals is simplified by introducing a physically plausible assumption that wave front shapes remain the same before and after each reflection on a reflective boundary. The proposed model can determine coherently the sound fields at arbitrary receiver locations in a flat waveguide, even when one boundary is highly sound absorptive.