Determination and load of organophosphorus and organochlorine pesticides at water from Jiulong River Estuary, China.

Seventeen organic phosphorus pesticides (OPs) and 18 organic chlorine pesticides (OCs) at water from Jiulong River Estuary (JLRE) are determined by SPE-GC-(FPD and microECD). The contents of the total OPs (17) ranged from 134.8 to 354.

Residue levels of HCHs, DDTs and PCBs in shellfish from coastal areas of east Xiamen Island and Minjiang Estuary, China.

Shellfish samples were collected from the coastal cultivating areas of east Xiamen Island and Minjing Estuary, China and analyzed for hexachlorocyclohexanes (HCHs), DDTs and polychlorinated biphenyls (PCBs) by GC. Concentration ranges of HCHs, DDTs and PCBs in the coastal area of east Xiamen Island were 0.18-345, 75.

[Polymorphisms of ACE-1 and MTHFR genes and genetic susceptibility of ischemic stroke].

Objective: To study the relationships between polymorphisms of angiotensin-converting enzyme 1 (ACE-1) gene and N(5),N(10) -methylene-tetra-hydrofolic acid reductase (MTHFR) gene and ischemic stroke (IS).

Methods: The polymorphisms of ACE-1 and MTHFR genes in the peripheral white blood cells of 143 patients with IS and 154 controls were analyzed using PCR- RFLP.

Results: The frequencies of II, ID, and DD genotypes of ACE-1 gene were 37.

Transport and fate of organochlorine pesticides in the River Wuchuan, southeast China.

Persistent organic pollutants (POPs) such as chlorinated pesticides are of global concern due to their widespread occurrence, persistence, bioaccumulation and toxicity to animals and human. This paper summarises recent research on 18 chlorinated pesticides in an important catchment in China, by determining their concentrations and behaviour in water, sediment, soil and plants. The concentrations of the total pesticides were in the ranges 187-893 ng l(-1) in river water, 8.

Distribution and transportation of polycyclic aromatic hydrocarbons in suspended particulate matter and surface sediment from the Pearl River Estuary.

Based on the quantitative and qualitative analysis of sixteen Polycyclic Aromatic Hydrocarbons (PAHs) with GC and GC-MSD, the concentrate distribution and transportation characteristics of PAHs in suspended particulate matter (SPM) and surface sediments (SS) from the Pearl River Estuary were studied. Whether in SPM or in SS, the concentration distribution of PAHs were characterized by acenaphthene (mean 55.5 microg/g in SPM, 226 ng/g in SS) with subordinate amounts of the tri- and tetra-cycle PAHs such as fluorene, fluoranthene, phenaphene and pyrene.

Delineating novel metabolic pathways of DPC 963, a non-nucleoside reverse transcriptase inhibitor, in rats. Characterization of glutathione conjugates of postulated oxirene and benzoquinone imine intermediates by LC/MS and LC/NMR.

The metabolic activation of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3,4-dihydro-2(1H)-quinazolinone, DPC 963, in rats was investigated by identifying and characterizing the GSH and mercapturic acid conjugates excreted in the bile and urine, respectively. The structures of these adducts, which were unequivocally elucidated by LC/MS/MS and NMR experiments, revealed the existence of at least three distinct metabolic pathways leading to these products. One of the pathways, which has been described previously, involves the activation of the acetylene group after an initial hydroxylation on the methine carbon of the cyclopropyl ring.