Optimization of γ-Aminobutyric Acid Production in Brown Rice via Prolonged Seed Priming.

Germinated whole seeds possess elevated levels of bioactive nutrients; however, their application is hindered by several constraints. The germination process is typically time-consuming, and germinated seeds present challenges in terms of storage and transportation compared to dry seeds. This study introduces a novel processing method for rice, termed prolonged priming (PLP), aiming to combine the benefits of germinated and dry seeds.

The Impact of Executive Functions and Musicality on Speech Auditory-Motor Synchronization in Adults Who Stutter.

Purpose: Stuttering is a neurodevelopmental disorder that disrupts the timing and rhythmic flow of speech production. There is growing evidence indicating that abnormal interactions between the auditory and motor cortices contribute to the development of stuttering. The present study investigated speech auditory-motor synchronization in stuttering adults and the influential factors behind it as compared to individuals without stuttering.

HO-1 represses NF-κB signaling pathway to mediate microglia polarization and phagocytosis in intracerebral hemorrhage.

Background: Microglia polarization plays a crucial role in inflammatory injury of brain following intracerebral hemorrhage (ICH). Heme oxygenase-1 (HO-1) has demonstrated protective properties against inflammation and promote hematoma clearance after ICH. The objective of this study was to explore impacts of HO-1 on microglia polarization and phagocytosis after ICH, along with the underlying mechanism.

Integrative modeling of POPs output flux from soil at a regional scale: A comprehensive approach.

Plot-scale natural attenuation models provide valuable insights into localized pollutant behavior but struggle to account for regional-scale hydrological processes. Existing research has predominantly concentrated on single processes, lacking comprehensive models to describe the output flux of persistent organic pollutants (POPs) by transport and transformation from soil at a regional scale. To address this gap, a model was developed by combining natural attenuation processes (e.

Coupling a process-driven model with geographic information system enables the spatial predication of cadmium in paddy soils.

Policies on the management of paddy fields are usually made at a broad scale and from a long-term perspective, while predicting the spatial extent of cadmium (Cd) contamination in paddy soils remains challenging. In this study, we developed a process-driven spatial model to quantify the transport of Cd in paddy soils and validated it against observed data from a 10-year regional investigation in southern China. Using a geographic information system and Monte Carlo simulation, the model was then applied to evaluate the effectiveness of different remediation strategies for contaminated paddy fields at field-to-regional scales in a 100-year period.

[Comprehensive Assessment of the Health Risk of Cadmium Exposure from Soil-wheat System in Wheat Fields in Northern China].

Accurately assessing the health risks of cadmium （Cd） exposure in the soil-wheat system is of great importance for the formulation of regional health risk prevention measures. Based on regional large-scale survey and Monte Carlo simulation methods, a case study on the health risk of Cd exposure in a soil-wheat system in a wheat production area of North China Plain was conducted by constructing a comprehensive health risk assessment （CHRA） model. The results showed that 73% of the soil samples in the study area exceeded the screening value of Cd for farmland soil （GB 15618-2018） and 57.

Dynamic estimation of the soil environmental carrying capacity for Benzo(a)pyrene in an industrial city, China: Insight from both duration and rate of regional emission.

An in-depth investigation of the maximum environmental load is crucial for soil security and pollution prevention. This research focused on soil environmental carrying capacity (SECC) for different risk receptors in a Chinese industrial city. By determining risk threshold for various land use types, we integrated mass balance and iterative models to capture dynamic net input fluxes with spatial heterogeneity.

Laparoscopy-assisted versus open surgery for low rectal cancer (LASRE): 3-year survival outcomes of a multicentre, randomised, controlled, non-inferiority trial.

Background: Laparoscopic surgery is increasingly used for rectal cancer, but the long-term oncological outcomes for low rectal cancer have not been fully established. We aimed to evaluate the 3-year survival outcomes of laparoscopic surgery versus open surgery in the treatment of low rectal cancer.

Methods: This multicentre, randomised, controlled, non-inferiority trial was conducted at 22 tertiary hospitals in China.

Britannin inhibits hepatocellular carcinoma development and metastasis through the GSK-3β/β-catenin signaling pathway.

Background: Hepatocellular carcinoma (HCC) stands out as a significant contributor to cancer-related death. Traditional Chinese Medicine (TCM) offers several advantages in the treatment of HCC. Britannin, a pivotal compound in Inulae Flos, has demonstrated pharmacological effects against various cancers, yet research on its specific anti-HCC effects remains limited.

Deciphering the code: the pivotal role of lncRNAs in advancing TNBC therapy.

Triple-negative breast cancer (TNBC) represents the most formidable subtype of breast cancer, characterized by a notable dearth in targeted therapeutic options. Deciphering the underlying molecular mechanisms of TNBC is pivotal for improving patient outcomes. Recent scientific advancements have spotlighted long non-coding RNAs (lncRNAs) as key players in the genesis, progression, and metastasis of cancers.

The clinical effect of endoscopic and open surgery in the treatment of thyroid cancer and their effect on the blood coagulation state: a comparative study.

Purpose: This study was performed to compare the therapeutic efficacy of endoscopic surgery and open surgery and their effects on postoperative blood coagulation state in patients with thyroid cancer, and to provide evidence for the prevention measurement of thrombosis in the perioperative period.

Methods: One hundred patients with thyroid cancer who received treatment in our hospital from January 2021 to December 2021, were randomly divided into an endoscopic group and an open surgery group, with 50 patients in each group. The patients in the open surgery group were treated by traditional open surgery, while patients in the endoscopic group accepted endoscopic surgery.

Prediction of soil heavy metal contents in urban residential areas and the strength of deep learning: A case study of Beijing.

Predicting soil heavy metal (SHM) content is crucial for understanding SHM pollution levels in urban residential areas and guide efforts to reduce pollution. However, current research indicates low SHM prediction accuracy in urban areas. Therefore, we employed a deep learning method (fully connected deep neural network) alongside four other methods (muti-layer perceptron, radial basis function neural network, multiple stepwise linear regression, and Kriging interpolation) to predict SHM content in the urban residential areas of Beijing and demonstrated the strength of deep learning in improving prediction accuracy.

Combined Application of Multiple Techniques in Prenatal Diagnosis of a Fetus with Turner Syndrome.

Background: The clinical features of Turner syndrome (TS) involve multiple organ system dysplasia, among which growth retardation and gonadal dysplasia are the most important clinical phenotypes.

Methods: G banding karyotype analysis, chromosome microarray (CMA), and fluorescence in situ hybridization (FISH) were used for prenatal diagnosis of fetal chromosomes.

Results: The result of fetal chromosome karyotype analysis was 46,XX.

Time series analysis of PM pollution risk based on the supply and demand of PM removal service: a case study of the urban areas of Beijing.

Demonstrating the temporal changes in PM pollution risk in regions facing serious PM pollution problems can provide scientific evidence for the air pollution control of the region. However, research on the variation of PM pollution risk on a fine temporal scale is very limited. Therefore, we developed a method for quantitative characterizing PM pollution risk based on the supply and demand of PM2.

Bayesian risk prediction model: An accessible strategy to predict cadmium contamination risk in wheat grain grown in alkaline soils.

Excessive cadmium (Cd) concentration in wheat grain is becoming a widespread concern in China. Considering the complexity of Cd transfer in the soil-wheat system, how the Cd risk in wheat grain be accurately predicted from the limited details available is of great significance for the risk management of Cd. Bayes' theory could leverage existing data by combining prior information and observational data, providing a promising strategy with which to calculate a more robust posterior probability of a grain sample exceeding the food safety standard (FSS) for Cd (0.

Research progress on the mechanism of action of Salvia miltiorrhiza and its components in the treatment of endometrial carcinoma.

The incidence and mortality of endometrial carcinoma (EC) are increasing year by year. Although the curative effect of surgery and commonly used drugs is clear, it is accompanied by obvious side effects, and safe and effective means are urgently needed to promote the curative effect and decrease the toxicity of drugs. Traditional Chinese medicine has been passed down for thousands of years in China and has proved to be advantageous in the treatment of various cancers and the auxiliary enhancement and reduction of toxicity.

Pan-cancer analysis of Sushi domain-containing protein 4 (SUSD4) and validated in colorectal cancer.

Sushi domain-containing protein 4 (SUSD4) is a complement regulatory protein whose primary function is to inhibit the complement system, and it is involved in immune regulation. The role of SUSD4 in cancer progression has largely remained elusive. SUSD4 was studied across a variety of cancer types in this study.

Complete mitochondrial genome of Lefèvre, 1893 (coleoptera: chrysomelidae: eumolpinae), a tea pest from Southern China.

The tea pest, Lefèvre 1893 (Chrysomelidae), belongs to the subfamily Eumolpinae. In this study, the complete mitochondrial genome sequence of from southern China was sequenced using the next-generation sequencing technique, assembled, and annotated using bioinformatics tools. The complete mitochondrial genome was 15,905 bp in length.