Biological and structural properties of curcumin-loaded graphene oxide incorporated collagen as composite scaffold for bone regeneration.

Introduction: To address the challenges related to bone defects, including osteoinductivity deficiency and post-implantation infection risk, this study developed the collagen composite scaffolds (CUR-GO-COL) with multifunctionality by integrating the curcumin-loaded graphene oxide with collagen through a freeze-drying-cross-linking process.

Methods: The morphological and structural characteristics of the composite scaffolds were analyzed, along with their physicochemical properties, including water absorption capacity, water retention rate, porosity, degradation, and curcumin release. To evaluate the biocompatibility, cell viability, proliferation, and adhesion capabilities of the composite scaffolds, as well as their osteogenic and antimicrobial properties, in vitro cell and bacterial assays were conducted.

Prognostic Value of Baseline Skeletal Muscle Index in Colorectal Cancer Patients Treated with Fruquintinib: A multi-center real world analysis.

Background: The Skeletal Muscle Index (SMI) serves as an objective metric for assessing nutritional status in patients with malignant tumors. Research has found baseline nutritional status can influence both the efficacy and prognosis of targeted anti-tumor therapies, with growth factor tyrosine kinase inhibitors frequently inducing drug-related sarcopenia. Fruquintinib has received approval for the treatment of metastatic colorectal cancer.

A case report of interstitial lung disease caused by HER2-positive breast cancer patient receiving two antibody-drug conjugate drugs successively.

Background: Comprehensive treatment of breast cancer includes surgery, radiotherapy, chemotherapy, endocrine therapy, targeted therapy and immunotherapy, and the means are extremely rich. In recent years, the antibody-drug conjugates (ADCs) have become one of the significant treatment drugs for patients with human epidermal growth factor receptor 2 (HER2)-positive. ADCs provides new treatment options, and it improves outcomes and quality of life for patients with HER2-positive advanced breast cancer.

Highly 002-Oriented Dendrite-Free Anode Achieved by Enhanced Interfacial Electrostatic Adsorption for Aqueous Zinc-Ion Batteries.

Rechargeable aqueous zinc-ion batteries (AZIBs) are gaining recognition as promising next-generation energy storage solution, due to their intrinsic safety and low cost. Nevertheless, the advancement of AZIBs is greatly limited by the abnormal growth of zinc dendrites during cycling. Electrolyte additives are effective at suppressing zinc dendrites, but there is currently no effective additive screening criterion.

Exosomes miR-92a-3p from human exfoliated deciduous teeth inhibits periodontitis progression via the KLF4/PI3K/AKT pathway.

Background: Periodontitis is a chronic inflammatory disease mediated by dysbiosis of the oral microflora, resulting in the destruction of periodontal tissue. Increasing evidence suggested that mesenchymal stem cell (MSCs) and exosomes derived from MSCs play a critical role in periodontal tissue regeneration. However, whether stem cells from exfoliated deciduous teeth (SHED)-secreted exosomes can improve the therapeutic potential of periodontitis is largely unknown.

Breaking the trade-off between capacity and stability in vanadium-based zinc-ion batteries.

Water in electrolytes is a double-edged sword in zinc-ion batteries (ZIBs). While it allows for proton insertion in the cathode, resulting in a significant increase in capacity compared to that of organic ZIBs, it also causes damage to electrodes, leading to performance degradation. To overcome the capacity-stability trade-off, organic solvents containing a small amount of water are proposed to mitigate the harmful effects of water while ensuring sufficient proton insertion.

POSS hybrid bioactive glass dental composite resin materials: Synthesis and analysis.

Introduction: This study create a dental composite by hybirding polyhedral oligo-sesquioxide nano monomers and bioactive glass BG 45S5.

Methods: Make an experimental composite resin material with a 60 % filler content overall by substituting 20 % of the filler with BG 45S5. The experimental resins are grouped and named P0, P2, P4, P6 and P8 based on the reactive nanomonomer methacrylic acid-based multifaceted oligomeric sesquisiloxane (POSS) added by 2 %-8 % in the resin matrix portion of each group.

Development of the mirror-image sensitivity for different object categories-Evidence from the mirror costs of object images in children and adults.

Object recognition relies on a multitude of factors, including size, orientation, and so on. Mirrored orientation, particularly due to children's mirror confusion in reading, holds special significance among various object orientations. Brain imaging studies suggest that the visual ventral and dorsal streams exhibit distinct orientation sensitivity across diverse object categories.

Atomic scale analysis of Zn storage in robust tunnel frameworks.

Realizing rapid and reversible Zn storage at the cathode is imperative for the advancement of aqueous Zn-ion batteries (ZIBs), which offer an excellent option for large-scale electrochemical energy storage. However, owing to limitations of the structural stability of previously investigated frameworks, the Zn storage processes remain unclear, thus hindering progress towards the above goal. Herein, we present the novel application of MoVTe oxide with an M1 phase (MVT-M1) as a potential cathode material for ZIBs.

Advancements in Achieving High Reversibility of Zinc Anode for Alkaline Zinc-Based Batteries.

Rechargeable alkaline zinc-based batteries (ZBBs) have attracted extensive research attention due to their advantages of low cost, high specific energy, and high safety. Although the investigation of cathodes for alkaline secondary ZBBs has reached a relatively advanced stage, the exploration of zinc anodes is still in its infancy. Zinc anodes in alkaline electrolytes encounter challenges such as dendrite formation, passivation, corrosion during periods of cell inactivity, and hydrogen evolution during cycling, thereby limiting their rechargeability and storability.

Enhancing Energy Conversion Efficiency and Durability of Alkaline Nickel-Zinc Batteries with Air-Breathing Cathode.

Despite their high output voltage and safety advantages, rechargeable alkaline nickel-zinc batteries face significant challenges associated with the cathodic side reaction of oxygen evolution, which results in low energy efficiency (EE) and poor stability. Herein, we propose to leverage the side oxygen evolution reaction (OER) in nickel-zinc batteries by coupling electrocatalysts for oxygen reduction reactions (ORR) in the cathode, thus constructing an air breathing cathode. Such a novel battery (Ni-ZnAB), designed in a pouch-type cell with a lean electrolyte, exhibits an outstanding EE of 85 % and a long cycle life of 100 cycles at 2 mA cm , which are significantly superior to those of traditional Ni-Zn batteries (54 %, 50 cycles).

Environmental Regulation, Resource Misallocation, and Total Factor Productivity: An Empirical Analysis Based on 284 Cities at the Prefecture-Level and Above in China.

We investigated the impact of environmental regulation on total factor productivity (TFP) based on a panel dataset of 284 cities at the prefecture-level and above in mainland China from 2006 to 2020 and examined whether environmental regulation had a resource reallocation effect and thus affected TFP. The results showed that there was an "inverted U-shaped" pattern in the impact of environmental regulation on TFP in China and a moderate strengthening of environmental regulation helped to increase TFP, which still held after endogeneity treatment and robustness tests. The "inverted U-shaped" relationship between environmental regulation and TFP in eastern, central, and western cities still held, while environmental regulation did not produce significant effects on TFP in the northeast.

Two subtypes of surgery-categorized upper-lateral intracavitary pregnancy identified by MRI, a retrospective study.

Background: The pregnancy outcomes in women with surgery-categorized upper-lateral intracavitary pregnancy (ULIP), previously named angular pregnancy, demonstrate higher heterogeneity than in women with ultrasonography-categorized ULIP. We aimed to use preoperative MRI and correlated clinical characteristics to explore whether the surgery-categorized ULIP comprises obstetric conditions undefined by the current ultrasonography-based diagnostic criteria.

Methods: This retrospective study involved 28 women with surgically and pathologically confirmed ULIP from January 2016 to July 2022.

Identifying Common Genes and Pathways Associated with Periodontitis and Aging by Bioinformatics Analysis.

Background: This work used bioinformatic analysis to identify the relationship between periodontitis (PD) and aging, which could lead to new treatments for periodontal disease in the elderly.

Method: Four microarray datasets were obtained from the Gene Expression Omnibus (GEO) database and analyzed in R language to identify differentially expressed genes (DEGs). The common DEGs of PD and aging were evaluated as key genes in this investigation by a Venn diagram.

Hewettite ZnV O ⋅ 8H O with Remarkably Stable Layers and Ultralarge Interlayer Spacing for High-Performance Aqueous Zn-Ion Batteries.

Aqueous Zn-ion batteries (ZIBs) are promising candidates for grid-scale energy storage because of their intrinsic safety, low-cost and high energy-intensity. Vanadium-based materials are widely used as the cathode of ZIBs, especially A V O  ⋅ nH O (AVO, A=NH , Na, K). However, AVO suffers from serious dissolution, phase transformation and narrow gallery spacing (∼3 Å), leading to poor cycling stability and rate capability.

Using MRI to differentiate upper-lateral intracavitary pregnancy and interstitial pregnancy for the patients with pregnancies in the uterotubal junction during the first trimester.

Objectives: To retrospectively evaluate the diagnostic value of MRI for the uterotubal junctional pregnancies during the first trimester.

Methods: This retrospective study involved 59 patients (January 2016 to July 2021) with a preoperative imaging diagnosis of uterotubal junctional pregnancy. Using operative and pathological reports as the reference standard, we identified 22 patients with upper-lateral intracavitary (angular) pregnancy and 37 patients with interstitial pregnancy.

Does Environmental Regulation Help Mitigate Factor Misallocation?-Theoretical Simulations Based on a Dynamic General Equilibrium Model and the Perspective of TFP.

How environmental regulation affects factor allocation is becoming an emerging hot topic in academia. In this paper, we construct a dynamic general equilibrium model accommodating environmental regulatory shock based on the H-K framework to explain the impact of environmental regulation on factor misallocation from the perspective of aggregate total factor productivity loss changes, and numerical simulation results are provided for several representative scenarios. The results show that environmental regulation has a significant effect on factor market misallocation, but this effect is not simply positive or negative, and it mainly depends on the firms' initial factor allocation status and the intensity of the shock.

Comparative investigations of and bioactivity of titanium Ti-24Nb-4Zr-8Sn alloy before and after sandblasting and acid etching.

To avoid the failure of clinical surgery due to "stress shielding" and the loosening of an implant, a new type of alloy, Ti-24Nb-4Zr-8Sn (TNZS), with a low Young's modulus acted as a new implant material in this work. Meanwhile, the surface characteristics, MC3T3-E1 cell behavior and osseointegration of the titanium and TNZS before and after sandblasting and acid etching were studied comparatively. TNZS and Ti had the same microstructure based on the transmission electron microscopy results.

Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.

Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridonin.

POSS Dental Nanocomposite Resin: Synthesis, Shrinkage, Double Bond Conversion, Hardness, and Resistance Properties.

Nanocomposite dental resins with 0, 2, 5, and 10 wt % methacryl polyhedral oligomeric silsesquioxane (POSS) as filler in the resin matrix were prepared by a light curing method.The atomic force microscopy (AFM), fourier transform infrared spectroscopy (FTIR), nanoindentation, and nanoscratch tests were carried out to study the effect of POSS contents on the compatibility, double bond conversion, volumetric shrinkage, hardness, modulus, and resistance of the dental resins. POSS was very uniformly dispersed and showed a good compatibility with the matrix.

Tanshinone IIA promotes osteogenic differentiation of human periodontal ligament stem cells via ERK1/2-dependent Runx2 induction.

Mesenchymal stem cells (MSCs) of the dental or craniofacial origin include Human periodontal ligament stem cells (hPDLSCs), which are able to readily differentiate into osteoblasts. Tanshinone IIA (TSA) is a diterpene quinone compound that is derived from Danshen (also known as Salvia miltiorrhiza) used frequently in the context of traditional Chinese medicine (TCM). This study sought to assess how TSA affects the osteogenic differentiation of hPDLSCs.

Combination of Taxol® and dichloroacetate results in synergistically inhibitory effects on Taxol-resistant oral cancer cells under hypoxia.

Cancer cells preferentially catalyze glucose through the glycolytic pathway in the presence of adequate oxygen. This phenomenon is known as the Warburg effect. As is the case with numerous cancer therapeutic agents, resistance remains a significant problem when using Taxol® to treat malignancies.

The β-SiC nanowires (~100 nm) induce apoptosis via oxidative stress in mouse osteoblastic cell line MC3T3-E1.

Silicon carbide (SiC), a compound of silicon and carbon, with chemical formula SiC, the beta modification ( β-SiC), with a zinc blende crystal structure (similar to diamond), is formed at temperature below 1700°C. β-SiC will be the most suitable ceramic material for the future hard tissue replacement, such as bone and tooth. The in vitro cytotoxicity of β-SiC nanowires was investigated for the first time.

Development of novel dental nanocomposites reinforced with polyhedral oligomeric silsesquioxane (POSS).

Objectives: It has been the focus to develop low shrinkage dental composite resins in recent ten years. A major difficulty in developing low shrinkage dental materials is that their deficiency in mechanical properties cannot satisfy the clinical purpose. The aim of this study is to develop novel dental nanocomposites incorporated with polyhedral oligomeric silsesquioxane (POSS).