Discovery of Janus Kinase and Histone Deacetylase Dual Inhibitors as a New Strategy to Treat Psoriasis.

Psoriasis is a common, chronic, recurrent, and inflammatory skin disease, which causes physical and psychological problems in patients and lacks effective and economic therapeutics. Herein, we designed Janus kinase (JAK) and histone deacetylase (HDAC) dual inhibitors as a new strategy for the treatment of psoriasis. In particular, compound was identified with excellent inhibitory activity toward JAKs (JAK2 IC = 0.

Comparison of nitrification inhibitors for mitigating cadmium accumulation in pakchoi and their associated microbial mechanisms.

The use of nitrification inhibitors has been suggested as a strategy to decrease cadmium (Cd) accumulation in crops. However, the most efficient nitrification inhibitor for mitigating crop Cd accumulation remains to be elucidated, and whether and how changes in soil microbial structure are involved in this process also remains unclear. To address these questions, this study applied three commercial nitrification inhibitors, namely, dicyandiamide (DCD), 3,4-dimethylpyrazole phosphate (DMPP), and nitrapyrin (NP), to pakchoi.

Optimizing bioelectromethanosynthesis of CO and membrane fouling mitigation in MECs via in-situ biogas recirculation.

The CO bioelectromethanosynthesis via two-chamber microbial electrolysis cell (MEC) holds tremendous potential to solve the energy crisis and mitigate the greenhouse gas emissions. However, the membrane fouling is still a big challenge for CO bioelectromethanosynthesis owing to the poor proton diffusion across membrane and high inter-resistance. In this study, a new MEC bioreactor with biogas recirculation unit was designed in the cathode chamber to enhance secondary-dissolution of CO2 while mitigating the contaminant adhesion on membrane surface.

Enhanced hydrolysis and methane yield of temperature-phased dewatered sludge anaerobic digestion by microbial electrolysis cell.

Temperature-phased anaerobic digestion (TPAD) and microbial electrolysis cell (MEC) are both able to improve hydrolysis and methane yield during anaerobic digestion (AD) of dewatered sludge. However, the effect of TPAD and MEC integration at different temperatures and different phases is unclear. This study investigated the effect of the integration of intermittent energization MEC in different phases of TPAD on the digestion of dewatered sludge.

3D-Printed Biomimetic Structural Colors.

Resolution control and expansibility have always been challenges to the fabrication of structural color materials. Here, a facile strategy to print cholesteric liquid crystal elastomers (CLCEs) into complex structural color patterns with variable resolution and enhanced expansibility is reported. A volatile solvent is introduced into the synthesized CLC oligomers, modifying its rheological properties and allowing direct-ink-writing (DIW) under mild conditions.

δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.

Wound healing is a complex physiological process for maintaining skin integrity after a wound. Bone marrow-derived mesenchymal stem cells (BMSCs) are excellent cellular candidates for wound healing, which could be enhanced by exogenous stimulation. We aimed to explore the role of δ-Tocotrienol (δ-TT) in BMSC ability of wound healing.

Enhanced treatment of sludge drying condensate by A/O-MBR process: Microbial activity and community structure.

With the rapid increase of sludge production from sewage treatment plants, the treatment of sludge drying condensate rich in a large amount of pollutants urgently needs to be addressed. Due to the unique characteristics of sludge drying condensate (high ammonia nitrogen and COD concentration), there are almost no reports on biological treatment methods specifically targeting sludge drying condensate. In this study, A/O-MBR process was proposed for sludge drying condensate treatment and the effects of ammonia nitrogen loads, alkalinity and aeration intensity were explored.

3D-Printed Intrinsically Stretchable Organic Electrochemical Synaptic Transistor Array.

Organic electrochemical transistors (OECTs) for skin-like bioelectronics require mechanical stretchability, softness, and cost-effective large-scale manufacturing. However, developing intrinsically stretchable OECTs using a simple and fast-response technique is challenging due to limitations in functional materials, substrate wettability, and integrated processing of multiple materials. In this regard, we propose a fabrication method devised by combining the preparation of a microstructured hydrophilic substrate, multi-material printing of functional inks with varying viscosities, and optimization of the device channel geometries.

Bioelectrochemical anaerobic membrane bioreactor enables high methane production from methanolic wastewater: Roles of microbial ecology and microstructural integrity of anaerobic biomass.

The disintegration of anaerobic sludge and blockage of membrane pores has impeded the practical application of anaerobic membrane bioreactor (AnMBR) in treating methanolic wastewater. In this study, bioelectrochemical system (BES) was integrated into AnMBR to alleviate sludge dispersion and membrane fouling as well as enhance bioconversion of methanol. Bioelectrochemical regulation effect induced by BES enhanced methane production rate from 4.

Biochar-supported magnesium oxide as high-efficient lead adsorbent with economical use of magnesium precursor.

With unique porous structure inherited from lignocellulose, biochar was an appropriate carrier for small-size MgO materials, which could simplify the synthetic process and better solve agglomeration and separation problems during adsorption. Biochar-supported MgO was prepared with impregnation method. Under different synthesis conditions, the obtained MgO presented diverse properties, and moderate pyrolysis condition was conducive to the improvement of Mg conversion rate.

Influence of adsorption sites of biochar on its adsorption performance for sulfamethoxazole.

In this study, the effects of various types of key adsorption sites on biochar were investigated on its adsorption capacity for sulfamethoxazole (SMX). The biochar obtained by carbonization of corncob at 800 °C (named CC800) was applied to the adsorption of SMX in aqueous environment. The adsorption of SMX by CC800 exhibited a "Three-stage downward adsorption ladder" characteristic in the whole pH range, which was attributed to the different mechanisms corresponding to different adsorption sites of CC800.

Insights into biodegradation behaviors of methanolic wastewater in up-flow anaerobic sludge bed (UASB) reactor coupled with in-situ bioelectrocatalysis.

Granular sludge disintegration and washing out pose a challenge to up-flow anaerobic sludge bed (UASB) reactor treating methanolic wastewater. Herein, in-situ bioelectrocatalysis (BE) was integrated into UASB (BE-UASB) reactor to alter microbial metabolic behaviors and enhance the re-granulation process. BE-UASB reactor exhibited the highest methane (CH) production rate of 388.

Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC.

Cancer stem-like cells (CSCs) are critically involved in cancer metastasis and chemoresistance, acting as one major obstacle in clinical practice. While accumulating studies have implicated the metabolic reprogramming of CSCs, mitochondrial dynamics in such cells remain poorly understood. Here we pinpointed OPA1hi with mitochondrial fusion as a metabolic feature of human lung CSCs, licensing their stem-like properties.

Mesangial cell: A hub in lupus nephritis.

Lupus nephritis (LN) is a severe renal disease caused by the massive deposition of the immune complexes (ICs) in renal tissue, acting as one of the significant organ manifestations of systemic lupus erythematosus (SLE) and a substantial cause of death in clinical patients. As mesangium is one of the primary sites for IC deposition, mesangial cells (MCs) constantly undergo severe damage, resulting in excessive proliferation and increased extracellular matrix (ECM) production. In addition to playing a role in organizational structure, MCs are closely related to immunomodulation by phagocytosis, antigen-presenting function, and inflammatory effects, aberrantly participating in the tissue-resident immune responses and leading to immune-mediated renal lesions.

Dual encoder network with transformer-CNN for multi-organ segmentation.

Medical image segmentation is a critical step in many imaging applications. Automatic segmentation has gained extensive concern using a convolutional neural network (CNN). However, the traditional CNN-based methods fail to extract global and long-range contextual information due to local convolution operation.

Conformational transition-induced simultaneous fluorescence enhancement of oxytetracycline and rhodamine B under a single excitation wavelength.

Since the abuse of antibiotic oxytetracycline (OTC) poses a serious threat to the environment and human health, it is of great importance to develop sensitive fluorescent probes for its rapid and detection. Herein, a dual fluorescence response probe based on an aluminum-incorporated metal-organic framework (MOF) was presented for OTC assay. Unlike internal references that demonstrate an independent and stable fluorescence signal intensity in traditional dual-emissive probes, the fluorescence of rhodamine B immobilized in a prepared probe was gradually enhanced at a 585 nm emission wavelength with increasing concentrations of OTC under 405 nm excitation, while OTC also experienced an obvious fluorescence enhancement at a 521 nm emission wavelength due to a molecular conformation transition from the twisted to the extended state, realizing a molecular conformational transition-induced dual fluorescence enhancement for OTC detection under a single excitation wavelength.

The ferroxidases are critical for Fe(II) oxidation in xylem to ensure a healthy Fe allocation in .

The long-distance transport of iron (Fe) in the xylem is critical for maintaining systemic Fe homeostasis in plants. The loading form of Fe(II) into the xylem and the long-distance translocation form of Fe(III)-citrate have been identified, but how Fe(II) is oxidized to Fe(III) in the xylem remains unknown. Here, we showed that the cell wall-resided ferroxidases LPR1 and LPR2 (LPRs) were both specifically expressed in the vascular tissues of , while disruption of both of them increased Fe(II) in the xylem sap and caused excessive Fe deposition in the xylem vessel wall under Fe-sufficient conditions.

The protective role of FTY720 in promoting survival of allograft fat in mice.

Fat transplantation is widely used for soft-tissue filling and wound repair. Owing to the biological changes in adipocytes in some metabolic diseases, allograft fat can provide a better source of donor fat than autologous fat. Fingolimod (FTY720) possesses a powerful immunomodulatory function.

Activation of peroxydisulfate via photothermal synergistic strategy for wastewater treatment: Efficiency and mechanism.

Peroxydisulfate (PDS)-based advanced oxidation processes (AOPs) have been demonstrated to be an effective technology for the removal of refractory organic contaminants from the aquatic environment. Herein, a photothermal synergistic strategy is developed to realize the green activation of PDS under solar light irradiation. An innovative solar photothermal reaction system and its corresponding evaluation method are established.

Transcatheter Angiographic Embolization of Percutaneous Nephrolithotomy-Related Bleeding: A Single-Center Experience.

Background: To evaluate the clinical characteristics and angiographic features of transcatheter angiographic embolization (TAE) in patients with active bleeding after percutaneous nephrolithotomy (PCNL).

Methods: Between 2009 and 2018, 45 patients who underwent TAE for hemorrhage control after PCNL were reviewed retrospectively. Patient clinical characteristics and angiographic features of TAE were analyzed.

Tobacco smoking and solid fuels for cooking and risk of liver cancer: A prospective cohort study of 0.5 million Chinese adults.

Previous research found tobacco smoking and solid fuel use for cooking to increase the risk of chronic liver disease mortality, but previous cohort studies have not investigated their independent and joint associations with liver cancer incidence in contemporary China. The China Kadoorie Biobank (CKB) study recruited 0.5 million adults aged 30 to 79 years from 10 areas across China during 2004 to 2008.

Analysis of the regulation of metastasis-associated lung adenocarcinoma transcript 1 on the biological behavior of breast cancer.

Background: Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a class of long non-coding RNA (lncRNA) that has been proved to be closely related to many cancers.

Methods: The relevant research on MALAT1 in cancers published in recent years were collected and integrated. CiteSpace was employed to draw a knowledge map of MALAT1 in breast cancer, to evaluate the research front-burner issues.