Esketamine Regulates Mitophagy through ULK1/FUNDC1 Signaling Pathway to Improve LPS-induced Acute Respiratory Distress Syndrome.

Background: As a heterogeneous clinical syndrome, acute respiratory distress syndrome (ARDS) is caused by infection-associated inflammation with limited treatment options. Esketamine possesses antiinflammatory properties, and it is effective in treating lung diseases.

Objective: This study aimed to unveil the efficacy and mechanism of esketamine in ARDS.

Anti-obesity effects of luteoloside on high fat diet induced obese mice: Modulation of white adipose tissue, gut microbiota, and PPAR signaling pathways.

The effect of luteoloside on the regulation of lipid metabolism imbalance in obese mice and its mechanism were investigated. After 12 weeks of luteoloside (25, 50 and 100 mg/kg), obesity-related indicators were analyzed, such as serum, liver and adipose tissue indexes as well as gut microbiota and liver tissue-related protein expression levels. The results suggested that luteoloside intervention could reduce body fat mass and fat storage, improve lipid levels, glucose tolerance, and alleviate inflammatory disorders, especially in medium-dose treated mice.

Gravity Data Fusion and Imaging of Geological Structures in the Red River Fault Zone and Adjacent Areas.

The geological structure in the Red River fault zone (RRF) and adjacent areas is complex. Due to the lack of high-precision gravity data in the study area, it is difficult to obtain the distribution of materials within the Earth's crust. In this study, a gravity data-fused method is proposed.

Determinants of generalized anxiety and construction of a predictive model in patients with chronic obstructive pulmonary disease.

Background: Patients with chronic obstructive pulmonary disease (COPD) frequently experience exacerbations requiring multiple hospitalizations over prolonged disease courses, which predispose them to generalized anxiety disorder (GAD). This comorbidity exacerbates breathing difficulties, activity limitations, and social isolation. While previous studies predominantly employed the GAD 7-item scale for screening, this approach is somewhat subjective.

Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease.

Renal ischemia-reperfusion (IR) induces tissue hypoxia, resulting in disrupted energy metabolism and heightened oxidative stress. These factors contribute to tubular cell damage, which is a leading cause of acute kidney injury (AKI) and can progress to chronic kidney disease (CKD). The excessive generation of reactive oxygen species (ROS) plays a crucial role in the pathogenesis of AKI.

Influence of psychological resilience on compassion fatigue in nurses in the operating room: a cross-sectional study in China.

Objective: To investigate the current state of compassion fatigue among operating room nurses, analyze the factors influencing compassion fatigue (particularly psychological resilience), and provide a basis for developing a compassion fatigue intervention program for operating room nursing managers.

Methods: This cross-sectional study was conducted in February 2022. A total of 258 operating room nurses were surveyed using the Professional Quality of Life (ProQOL) scale and the Resilience Scale for Adults (RSA).

Construction of novel hyper-crosslinked polymers with adjustable hydrophilicity for efficient extraction of nitroimidazoles.

To effectively control food safety risks caused by nitroimidazoles (NDZs), a sensitive detection method was established on the basis of a newly-developed solid-phase extraction (SPE) sorbent named as Phl-TBM that is a porous polymer prepared by crosslinking natural phloretin with (2,4,6-tris(bromomethyl)mesitylene. The Phl-TBM presented outstanding NDZs adsorption capacity, which can be ascribed to its well-developed porosity and multiple hydrogen bonding sites. With Phl-TBM as SPE sorbent, NDZs were successfully isolated and enriched from lake water, Basa fish, and beef before being assayed by high-performance liquid chromatography-diode array detector.

[Berberine regulates glucose and lipid metabolism via clock-controlled genes to ameliorate insulin resistance of hepatocytes].

This study aims to investigate the mechanism of berberine in regulating the metabolism network via clock-controlled genes represented by brain and muscle arnt-like 1(BMAL1) to ameliorate insulin resistance(IR) of hepatocytes in vitro. The HepG2 cell model of dexamethasone-induced IR(IR-HepG2) was established and treated with 5, 10, and 20 μmol·L~(-1) berberine, respectively, for 24 h. The glucose oxidase method and cell counting kit-8(CCK-8) assay were employed to measure extracellular glucose concentration and cell viability, respectively.

[Anti-tumor therapy strategy of CAR-T cells based on stem cell memory and central memory cells].

Cancer immunotherapy including immune checkpoint inhibitors and adoptive cell therapy has gained revolutionary success in the treatment of hematologic tumors; however, it only gains limited success in solid tumors. For example, chimeric antigen receptor T (CAR-T) cell therapy has shown significant effects and potential for curing patients with B-cell malignancies. In contrast, it remains a challenge for CAR-T cell therapy to gain similar success in solid tumors.

Effect of perioperative dexmedetomidine on recovery of postoperative gastrointestinal function in patients with general anesthesia: a systematic review and meta-analysis.

Background: There is controversy surrounding the influence of dexmedetomidine on the recovery of postoperative gastrointestinal dysfunction in patients under general anesthesia. The main purpose of this meta-analysis is to evaluate the effect of dexmedetomidine administration during the perioperative period on the recovery of gastrointestinal function in patients under general anesthesia.

Methods: A systematic review and meta-analysis with trial sequential analysis was performed to identify randomized controlled trials comparing dexmedetomidine administration with placebo for the recovery of gastrointestinal function.

Mechanism of RBM15 in the malignant proliferation of colorectal cancer cells through regulating the stability of LncRNA FGD5-AS1 via m6A modification.

Colorectal cancer (CRC) is the third most prevalent cancer all around the world. This study explored the mechanism of RBM15-mediated m6A modification in CRC cell malignant proliferation. The expression of RBM15, LncRNA FGD5-AS1, and HOXC10 was detected in CRC cells.

The association of RBP4 with chronic kidney diseases in southern Chinese population.

Background: Retinol binding protein 4 (RBP4), as a novel adipokine, has been proven to be highly related to insulin resistance, obesity, diabetes, hypertension, hyperuricemia and other metabolic diseases, which are all risk factors for chronic kidney disease (CKD). However, there is a lack of sufficient studies to explore the relationship between RBP4 and CKD, and no reports have described the predictive value of RBP4 for CKD. This study was designed to clarify the relationship between RBP4 and CKD and its potential predictive value.

Capsaicin and Quercitrin Maintained Lipid Homeostasis of Hyperlipidemic Mice: Serum Metabolomics and Signaling Pathways.

Capsaicin and quercitrin have proved to be two major ingredients in fresh chili pepper. However, the effect of these two compounds on hyperlipidemia and the related molecular mechanisms were still unclear. This work was performed to examine the hypolipidemic capacity of capsaicin and quercitrin as well as the related signaling pathways.

A "four-in-one" immunochromatographic strip for multi-readout detection of diazepam in lake water and fish via nanozyme-mediated colorimetric, catalytic, and photothermal activities.

The presence of psychotropic drugs (PDs) in aquatic ecosystems represents an increasing environmental problem, posing a serious threat to human health and aquatic organisms. Lateral flow immunoassays (LFIA) have been widely used in the detection of PD contaminants. However, maintaining signaling tag reporting activity and achieving LFIA's multi-readout capability remain significant challenges to meeting a range of detection scenarios.

Design of sulfonic group based hyper cross-linked polymer as adsorbent for efficient enrichment of endocrine disrupters.

The necessity for the development of effective adsorbents to capture endocrine disrupting chemicals (EDCs) from environmental and food samples arises from the potential health hazards that the EDCs may impose on human beings. Hence, a novel sulfonic group based hyper cross-linked polymer (HQSA-PLE-HCP) was synthesized and explored in solid phase extraction for the enrichment of some EDCs. The HQSA-PLE-HCP demonstrated an excellent adsorption capability for some EDCs (bisphenol F, bisphenol A, bishydroxyphenylbutane and p-tert-butylphenol).

Comprehensive Analysis of RNA Methylation-Regulated Gene Signature and Immune Infiltration in Ischemia/Reperfusion-Induced Acute Kidney Injury.

Introduction: The morbidity and mortality of acute kidney injury (AKI) are increasing. Epigenetic regulation and immune cell infiltration are thought to be involved in AKI. However, the relationship between epigenetic regulation and immune cell infiltration in AKI has not been elucidated.

A Combined Impact of Low-Voltage Electrostatic Field and Essential Oil on the Postharvest Properties of Chili Pepper: Insights into Related Molecular Mechanisms.

This research is intended to ascertain the impact of low-voltage electrostatic field (LVEF) together with chili pepper leaf essential oil (CLEO) on the storage quality of chili pepper. Four groups of samples were investigated, namely, control (CK), CLEO, LVEF, and CLEO + LVEF. Chili pepper from the CLEO + LVEF group reduced the weight loss and malondialdehyde content but improved the ascorbic acid contents, antioxidant potential, firmness, and color attributes.

Improvement of Storage Quality of Broccoli Using a Cold-Shock Precooling Way and the Related Molecular Mechanisms.

This research was performed to ascertain the impact of cold shock precooling and the underlying mechanism on broccoli storage quality. After being harvested and placed at 0 ± 2 °C, the broccoli was sealed in polyethylene bags and stored at 4 ± 2 °C. Cold-shock precooling showed superior qualities in terms of higher hardness, titratable acidity, moisture content, soluble protein, and chlorophyll, as well as more abundant volatile compounds, better sensory quality, antioxidant capacity, and decreased weight loss in comparison to without cold shock.

A three-dimensional nitrogen-rich conjugated microporous polymer for solid-phase microextraction of nitroaromatic compounds from environmental water and soil samples.

Nitroaromatic compounds (NACs), as a kind of important chemical intermediates, are widely used in industrial productions. However, NACs have carcinogenic effect and their residues may pose harm to human health. Therefore, there is necessity to set up effective analytical method to monitor them in some environmental samples.

TARGETING S100A9-TLR2 AXIS CONTROLS MACROPHAGE NLRP3 INFLAMMASOME ACTIVATION IN FATTY LIVER ISCHEMIA REPERFUSION INJURY.

Liver ischemia reperfusion (IR) injury significantly impacts clinical outcomes by increasing the risk of hepatic dysfunction after liver surgery. Fatty livers are more susceptible to IR stress. Recent studies have demonstrated that S100A9 plays a crucial role in both IR injury and the progression of liver steatosis.

S100A9 regulates M1 macrophage polarization and exacerbates steatotic liver ischemia-reperfusion injury.

Objective: Steatotic livers exhibit higher susceptibility to ischemia reperfusion (IR) injury, which increase the risk of primary graft non-function following liver transplantation. S100A9 is identified as a pivotal innate immune sensor that regulates the progression of liver diseases. However, its significance in steatotic liver IR injury remains under-investigated.

[Mechanism of berberine in improving adipocytic IR by mediating BMAL1:CLOCK complex and regulating glucose and lipid metabolism].

To explore the action mechanism of berberine in improving adipocytic insulin resistance(IR) by mediating brain and muscle arnt-like 1(BMAL1): circadian locomotor output cycles kaput(CLOCK) complex and regulating glucose and lipid metabolism. After the IR-3T3-L1 adipocyte model was established by dexamethasone induction for 96 h, 0.5, 1, 5, 10, and 20 μmol·L~(-1) berberine was administered for 24 h.

Synthesis and characterization of chitosan Schiff base grafted with formaldehyde and aminoethanol: As an effective adsorbent for removal of Pb(II), Hg(II), and Cu(II) ions from aqueous media.

Grafted chitosan materials show the characteristics of high stability, easy separation and recovery, and good heavy metal adsorption capacity, and have received much attention in the adsorption process. Therefore, in this work, novel grafted chitosan-based adsorbent CS-EHBSB@F-AE was prepared by a one-pot reaction of chitosan (CS), 3-ethoxy-4-hydroxybenzaldehyde (EHB), formaldehyde (F) and aminoethanol (F). The microstructure and morphology of the as-prepared composite CS-EHBSB@F-AE were characterized by FT-IR, TGA, DSC, FE-SEM, and BET analyses.