Suitability of Rosaceae fruit tree species for Panonychus citri (McGregor) (Acari: Tetranychidae).

The citrus red mite (CRM), Panonychus citri (McGregor) (Acari: Tetranychidae), a worldwide pest chiefly infesting Citrus plants, has spread from Southern China to Northern China. Little information is known about the population performance of CRM on the plants except for citrus trees and pear trees. In order to evaluate the extent of damage might caused by CRM to the fruit trees cultivated in Northern China, the performance of CRM on four Rosaceae species, including three main fruit tree species (pear-Pyrus pyrifolia Nakai cv.

The toxicity of lead on human neuroblastoma cells was alleviated by HUC-MSC-derived exosomes through miR-26a-5p/PTEN pathway.

Lead is a ubiquitous environmental chemical with various toxic damage to human body. This investigation aimed to explore the intervention effect of human umbilical cord mesenchymal stem cells derived exosomes (HUC-MSC-exo) on the neurotoxicity of lead and the relevant mechanism. Differential gradient ultracentrifugation was adopted to isolate HUC-MSC-exo.

GPRC5A promotes lung colonization of esophageal squamous cell carcinoma.

Emerging evidence suggests that cancer cells may disseminate early, prior to the formation of traditional macro-metastases. However, the mechanisms underlying the seeding and transition of early disseminated cancer cells (DCCs) into metastatic tumors remain poorly understood. Through single-cell RNA sequencing, we show that early lung DCCs from esophageal squamous cell carcinoma (ESCC) exhibit a trophoblast-like 'tumor implantation' phenotype, which enhances their dissemination and supports metastatic growth.

Elucidating the role of CYFIP2 in conferring cisplatin resistance in esophageal squamous cell carcinoma.

Cisplatin (CDDP) serves as a vital component in the chemotherapeutic approach to treat esophageal squamous cell carcinoma (ESCC). However, prolonged CDDP application frequently culminates in resistance, compromising therapeutic outcomes. Through genome-wide CRISPR library screening, our study elucidates the mechanisms underlying this resistance, pinpointing CYFIP2 as a pivotal mediator.

Primary Amine-Functionalized Chiral Covalent Organic Framework Enables High-Efficiency Asymmetric Catalysis in Water.

Aqueous asymmetric catalysis using chiral covalent organic frameworks (COFs) represents a significant advancement but remains to be explored. Herein, we present the first example of aqueous asymmetric catalysis catalyzed by a primary amine-tagged chiral -ADP-TAPB COF. The -ADP-TAPB COF was synthesized by the postsynthetic deprotection of -ADP-TAPB-Boc bearing a protective tert-butoxycarbonyl (Boc) group, which was constructed by a Schiff-base reaction between an alanine-derived chiral building block (-ADP-Boc) and 1,3,5-tris(4-aminophenyl)benzene (TAPB).

Association between serum IgM and all-cause mortality risk in Chinese centenarians: a prospective cohort study.

Background: We investigated the associations between IgM, IgG, IgA, and IgE levels and all-cause mortality risk in Chinese centenarians.

Methods: All participants were from the China Hainan Centenarian Cohort Study. Eligible participants were divided into quartiles based on their IgM, IgG, IgA, and IgE levels.

Biomarkers of lymph node metastasis in esophageal cancer.

Esophageal cancer (EC) is among the most aggressive malignancies, ranking as the seventh most prevalent malignant tumor worldwide. Lymph node metastasis (LNM) indicates localized spread of cancer and often correlates with a poorer prognosis, emphasizing the necessity for neoadjuvant systemic therapy before surgery. However, accurate identification of LNM in EC presents challenges due to the lack of satisfactory diagnostic techniques.

Targeted Muscle Reinnervation in the Upper Arm: A Functional Anatomical Study.

Background: The aim of this study was to accurately locate the neural fascicle controlling hand movement in the upper arm, to enhance expression of motor intention after targeted muscle reinnervation.

Methods: The right sides of the median, ulnar and radial nerves were dissected from distal to proximal in 6 fresh cadaver specimens. The sectional location and diameter of the functional fascicle were measured at 10 and 20 cm below the acromion.

Synthesis, Crystal Structures and Antibacterial Activity of Nickel(II), Cadmium(II) and Zinc(II) Complexes with Hydrazone Ligands.

Three mononuclear nickel(II), cadmium(II) and zinc(II) complexes, [NiL2]·2CH3OH·H2O (1), [CdI2(HL)]·CH3OH (2) and [ZnL2] (3), have been synthesized from 3-hydroxy-4-methoxy-N'-[(Z)-(pyridin-2-yl)methylidene]benzohydrazide (HL) by microwave irradiation method. All complexes were characterized by CHN elemental analyses and infrared spectra. Structures of the complexes were further studied by single crystal X-ray determination, which reveals that the Ni and Zn atoms in complexes 1 and 3 are in octahedral coordination, and the Cd atom in complex 2 is in square pyramidal coordination.

Structural Comparisons, Fluorescence Properties, and Glass-to-Crystal Transformations of Heat-Cooled and Melt-Quenched Zeolitic Imidazolate Framework Glass.

As a representative of zeolitic imidazolate framework glass, agZIF-62 has been reported to be synthesized using a melt-quenching method in which the ZIF-62 crystal is heated to a temperature above the melting point. Interestingly, we unexpectedly found that agZIF-62 can also be synthesized by simple heating at temperatures lower than the melting point, which may be assisted by the release of encapsulated solvent molecules. The structural differences between melt-quenched agZIF-62 (MQ-agZIF-62) and heat-cooled agZIF-62 (HC-agZIF-62) were investigated.

Experience in the diagnosis and treatment of non-invasive bilateral carotid cavernous sinus fistula based on CT image examination.

Carotid cavernous fistula is a rare but clinically important vascular abnormality that is challenging to diagnose and treat. The clinical data of a patient with bilateral carotid cavernous fistula diagnosed by CT images were retrospectively analyzed. Through the analysis of CT images, the patient was accurately located and the diagnosis was confirmed.

SORBS2-Mediated inhibition of malignant behaviors in esophageal squamous cell carcinoma through TIMP3.

Background: Esophageal squamous cell carcinoma (ESCC) is characterized by high invasiveness and poor prognosis. The role of Sorbin and SH3 domain-containing protein 2 (SORBS2) in ESCC remains largely unexplored.

Methods: The expression levels of SORBS2 in ESCC were detected using RNA-seq and proteomics data.

βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning.

Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and adipose tissue. Deletion of the hypothalamic RIIβ gene centrally induces WAT browning, yet the peripheral mechanisms mediating this process remain unexplored.

COVID-19 epidemic investigation study of a follow-up cohort of patients with diabetic kidney disease.

Introduction: The impact of coronavirus disease 2019 (COVID-19) on diabetic kidney disease (DKD) patients in China is not fully understood. This study aimed to investigate infection status in a DKD cohort post-renal biopsy and analyze vaccination and infection rates, as well as symptom severity, across various renal pathologies in DKD patients.

Methods: This epidemiological survey, centered on COVID-19, employed a Chinese DKD and renal puncture follow-up cohort.

Preparation and Research on Mechanical Properties of Eco-Friendly Geopolymer Grouting Cementitious Materials Based on Industrial Solid Wastes.

Red mud (RM), a hazardous solid waste generated in the alumina production process, of which the mineral composition is mainly hematite, is unable to be applied directly in the cement industry due to its high alkalinity. With the rise of geopolymers, RM-based grouting materials play an essential role in disaster prevention and underground engineering. To adequately reduce the land-based stockpiling of solid wastes, ultrafine calcium oxide, red mud, and slag were utilized as the main raw materials to prepare geopolymers, the C-R-S (calcium oxide-red mud-slag) grouting cementitious materials.

Correlation between retinal vascular geometric parameters and pathologically diagnosed type 2 diabetic nephropathy.

Background: Diabetic nephropathy (DN) and diabetic retinopathy (DR) are common microvascular complications of diabetes. The purpose of this study was to investigate the correlation between retinal vascular geometric parameters and pathologically diagnosed type 2 DN and to determine the capacity of retinal vascular geometric parameters in differentiating DN from non-diabetic renal disease (NDRD).

Methods: The study participants were adult patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease who underwent a renal biopsy.

Candesartan Cilexetil Formulations in Mesoporous Silica: Preparation, Enhanced Dissolution In Vitro, and Oral Bioavailability In Vivo.

Candesartan cilexetil (CC) is one of well-tolerated antihypertensive drugs, while its poor solubility and low bioavailability limit its use. Herein, two mesoporous silica (Syloid XDP 3150 and Syloid AL-1 FP) and the corresponding amino-modified products (N-XDP 3150 and N-AL-1 FP) have been selected as the carriers of Candesartan cilexetil to prepare solid dispersion through solvent immersion, and characterized through using powder X-ray diffraction analysis, infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, and solid-state nuclear magnetic resonance spectroscopy, etc. The state of CC changed from crystalline to amorphous after loading onto the silica carriers, in which no interactions between CC and silica existed.