An Overview of Drug Delivery Nanosystems for Sepsis-Related Liver Injury Treatment.

Sepsis, which is a systemic inflammatory response syndrome caused by infection, has high morbidity and mortality. Sepsis-related liver injury is one of the manifestations of sepsis-induced multiple organ syndrome. To date, an increasing number of studies have shown that the hepatic inflammatory response, oxidative stress, microcirculation coagulation dysfunction, and bacterial translocation play extremely vital roles in the occurrence and development of sepsis-related liver injury.

Successful treatment of disseminated nocardiosis diagnosed by metagenomic next-generation sequencing: A case report and review of literature.

Background: is an infrequently found bacterium with the potential to cause severe infection, with a predilection for the central nervous system, both in immunocompromised and immunocompetent individuals. Rapid etiological diagnosis of nocardiosis can facilitate timely and rational antimicrobial treatment. Metagenomic next-generation sequencing (mNGS) can improve the rate and reduce the turnaround time for the detection of .

[Clinical and immunological features of lupus nephritis in children: retrospective analysis of 40 cases].

Objective: To analyze the clinical and immunological features of children with lupus nephritis (LN).

Methods: Chart records of 40 (4 male and 36 female) LN children who were admitted consecutively between January, 2005 and December, 2010 were reviewed. The baseline demographic, pathological and immunological data were analyzed.

[The diversity of ghrelin gene in its products and functions].

By alternative splicing and posttranslational modification, ghrelin gene encodes multiple products ranging from acyl-ghrelin, des-acyl-ghrelin, to obestatin. These products exhibit diverse functions such as stimulating growth hormone secretion, regulating food uptake, glucose and lipid metabolism, protecting cardiovascular system, and modulating immune and inflammation. This review summarizes the recent advances on the products of ghrelin gene and their diverse functions.

Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism.

The obesity epidemic imposes a significant health burden on human beings. Current understanding of the mechanisms underlying the development of obesity is incomplete and contemporary treatment is often ineffective. Gastrointestinal hormones are important regulators of food intake and energy metabolism.

[Localization and expression of Slingshot-1L in peripheral eosinophils from patients with acute asthma exacerbation].

Objective: Eosinophils play a pivotal role in asthmatic airway inflammation. We previously found a significantly high expression of Slingshot-1L (SSH-1L) in peripheral eosinophils in acute exacerbations of asthma. Objective To investigate the expression and localization patterns of SSH-1L in peripheral blood eosinophils of asthmatic patients and their changes after treatment with inhaled corticosteroids.

[Directional differentiation of adipose-derived stem cell].

Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) derived from adipose tissue, which have the ability to self-renew and differentiate into many types of tissues. Here we summarize the recent advances in the research of ADSCs, introduce the methods of ADSCs isolation and culture, and discusse the factors regulating the adipo-differentiation and osteo-differentiation of ADSCs. The present review will yield novel insight relevant to the therapeutic intervention of obesity and osteo-tissue engineering.

[Lung cancer in pregnancy: report of two cases and review of literature].

Objective: to raise awareness about lung cancer in pregnancy.

Methods: the clinical presentations, diagnosis and treatment of 2 cases of lung cancer in pregnancy were reported, and related literatures were reviewed.

Results: The first case was a 31-year-old pregnant woman at 34(th)-week gestation, who presented with right sided pleural effusion on a Chest X-ray film.

[Effect of age on vascular calcification induced by vitamin D3 and nicotine].

Objective: To explore the effect of age on vascular calcification induced by vitamin D3 and nicotine.

Methods: Vascular calcification in rats was induced by administration of vitamin D3 plus nicotine (VDN treatment). After six weeks, Von Kossa staining, calcium content, alkaline phosphatase activity, phosphorus and calcium content in plasma were assayed.

[Clinical and pathological features of Alport syndrome in children].

Objective: To study the clinical and pathological features of Alport syndrome in children.

Methods: The clinical and histopathological data of 10 hospitalized children with Alport syndrome from February 2007 to February 2009 were retrospectively reviewed.

Results: There were 7 males and 3 females, with the age ranging from 2 years to 6 years and 7 months (mean 3 years and 2 months).

[NADPH oxidase-derived reactive oxygen species involved in angiotensin II-induced monocyte chemoattractant protein-1 expression in mesangial cells].

Objective: To investigate the origin of oxidative stress induced by angiotensin II (AngII) in human mesangial cells and the role of reactive oxygen species (ROS) in AngII-induced monocyte chemoattractant protein-1 (MCP-1) expression.

Methods: MCP-1 expression was determined by real time RT-PCR. ROS production was measured by DCFDA fluorescence.

[The effects of core proteoglycan on the expressions of I and III collagen in human renal tubular epithelial cell induced by TGFbeta1 in vitro].

Aim: To explore the roles of core proteoglycan and TGFbeta1 on the expressions of I and III collagen in human renal tubular epithelial cell line(HK-2) in vitro.

Methods: Confluent HK-2 cells were exposed to TGFbeta1 and core proteoglycan for up to 48 h. The cells were divided into four groups.

Effects of ghrelin on neuronal survival in cells derived from dorsal motor nucleus of the vagus.

Background: The effects of intestinal inflammation on the central neurons projecting to the enteric nervous system are unknown. The dorsal motor nucleus of the vagus signals to the gastrointestinal system. Ghrelin is elevated in patients with inflammatory bowel disease and has been implicated as an inflammatory mediator.

Effect of intestinal inflammation on neuronal survival and function in the dorsal motor nucleus of the vagus.

Background: The effects of intestinal inflammation on the central nervous system are unknown. The dorsal motor nucleus of the vagus (DMNV) integrates peripheral and central signals and sends efferent signals to the gastrointestinal system. The purpose of this study was to determine the effects of intestinal inflammation on the DMNV in an animal model and in vitro.

[Determination of trace elements in hair of mice infected with Trichinella spiralis].

Mice were divided into 3 groups: heavy infection group with 80 mice each was fed with 400 muscle larvae of Trichinella spiralis, light infection group with 60 mice each was fed by 200 larvae, and uninfected control (60 mice) . The content of Cu, Zn and Fe in the dorsal hair samples was measured in the week of 1, 3, 5, 7, 9, 11, 13 and 15 after infection. Results indicated that the content of Zn, Cu and Fe in the two experimental groups reduced considerably in comparison to the control (P < 0.

[Role of Slingshot-1L in peripheral eosinophils of asthmatic patients].

Objective: To investigate the expression of Slingshot-1L (SSH-1L) in peripheral blood eosinophils of asthmatic patients.

Methods: Peripheral vein blood sample of 30 ml was collected from 15 healthy volunteers, 15 asthmatic patients with glucocorticoid treatment and 15 asthmatic patients without the treatment. The eosinophils were isolated, purified and counted for each sample, and SSH-1L/beta-actin gene fragments were amplified simultaneously by RT-PCR for the total RNA.

[The experimental study of garlicin in treating Pneumocystis carinii pneumonia in rats].

Objective: To assess the therapeutic effect of garlicin on Pneumocystis carinii pneumonia (PCP) of immunosuppressed rats.

Methods: The Wistar rats were injected intramuscularly continually with dexamethasone for eight weeks to establish the rat model of PCP. The rats were treated with garlicin, meanwhile control groups without treatment and with SMZ-TMP treatment were established respectively in PCP model.

[Induction of monocyte chemoattractant protein-1 expression in human mesangial cells by angiotensin II: role of c-Jun N-terminal kinase-c-Jun/activator protein-1 signal pathway].

Objective: To investigate the role of c-Jun N-terminal kinase (JNK)-c-Jun/activator protein-1 (AP-1) signal pathway in expression of monocyte chemoattractant protein-1 (MCP-1) in experimental rat glomerulonephritis.

Methods: Nephrotoxic sera nephritis (NTN) was induced by injection of anti-GBM antibody into the tail veins of rats. Electrophoretic mobility shift assay (EMSA) and non-radioactive kinase assay were used to detect the activity of AP-1 and JNK in kidneys and angiotensin II-stimulated human mesangial cells.