The acyl-CoA-binding protein VdAcb1 is essential for carbon starvation response and contributes to virulence in .

Unlabelled: In the face of carbon, nitrogen, and phosphorus starvation, microorganisms have evolved adaptive mechanisms to maintain growth. In a previous study, we identified a protein predicted to contain acyl-CoA-binding domains in the plant pathogenic fungus . The predicted protein, designated VdAcb1, possesses an atypical signal peptide.

Roles of 12-Lipoxygenase and Its Interaction with Angiotensin II on p21 and p27 Expression in Diabetic Nephropathy.

Background: 12-Lipoxygenase (12-LO) and angiotensin II (Ang II) are involved in the development of diabetic renal hypertrophy, in which cyclin-kinase inhibitors, p21 and p27 play pivotal roles. Here, we study the effects of 12-LO and its interaction with Ang II on glomerular p21 and p27 expression in diabetic conditions.

Methods: Models used in the current study include glomerular mesangial cells (MCs); and glomeruli from (1) type 2 diabetic db/db mice; (2) type 2 diabetic rats induced by high-fat diet feeding followed by streptozotocin injection; (3) 12-LO knockout (12-LOKO) mice; and (4) normal rats infused with Ang II or 12(S)-hydroxyeicosatetraenoic acid (12[S]-HETE, arachidonic acid metabolite of 12-LO).

Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury.

The current lack of complete understanding of the pathogenesis of acute kidney injury (AKI) is a significant barrier to its early diagnosis and treatment. Cell cycle arrest plays an important role in the protection of renal tubular epithelial cells and maladaptive repair following AKI. G1 phase cell arrest serves as a protective mechanism following AKI, avoiding replication of damaged DNA.

Renal protective effect of sirtuin 1.

Silent information regulator 2 (Sir2) is a nicotinamide adenine dinucleotide- (NAD(+)-) dependent deacetylase. The homology of SIRT1 and Sir2 has been extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD(+) and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways.

[Quantitative prediction of soil salinity content with visible-near infrared hyper-spectra in northeast China].

Studying the spectral property of salinized soil is an important work, for it is the base of monitoring soil salinization by remote sense. To investigate the spectral property of salinized soil and the relationship between the soil salinity and the hyperspectral data, the field soil samples were collected in the region of Northeast China and then reflectance spectra were measured. The partial least squares regression (PLSR) model was established based on the statistical analysis of the soil salinity content and the reflectance of hyperspectra.

[Effect of cisplatin on apoptosis of spiral ganglion cell and expression of caspase-3 in mouse cochlea].

Objective: To establish a mice model of cisplatin-induced ototoxicity, and to investigate the effect of cisplatin on apoptosis of spiral ganglion cell and expression of caspase-3 in mouse cochlea.

Methods: Terminal deoxynucleotidyl transferase-mediated nick end labeling method (TUNEL) was used to monitor the apoptosis of spiral ganglion cell. Envision method of immunohistochemistry was applied to detect the expression of caspase-3 in cochlea.

[Estimates and affecting factors of soil organic carbon storages in Yunnan-Guizhou-Guangxi Region of China].

Soil organic carbon (SOC) plays a key role in the terrestrial eco-systems. However, there is a large variation in SOC estimates at regional and global scales. In order to improve the accuracy of SOC estimates, the SOC storage in Yunnan-Guizhou-Guangxi Region of China (include Yunnan Province, Guizhou Province and Guangxi Zhuang Municipality) was estimated using 798 soil profiles and 1:500 000 digitized soil map, and the dominant affecting factors on SOC density were also discussed employing stepwise regression and path analysis.

[Multiple central clinical studies on the needling method for regulating wei and strengthening brain for treatment of insomnia].

Objective: To observe the clinical therapeutic effect of the needling method for regulating wei and strengthening brain on insomnia.

Methods: Two hundred cases of insomnia were randomly divided into a test group and a control group, 100 cases in each group. The test group were treated with the needling method for regulating wei and strengthening brain with Baihui (GV 20), Dazhui (GV 14), Shenmai (BL 62), Zhaohai (KI 6) and ear points Yuanzhong, Shenmen selected; and in the control group, Sishencong (EX-HN 1), Shenmen (HT 7) and Sanyinjiao (SP 6) were selected.