Publications by authors named "Wei-ming Hu"

Laryngeal squamous cell carcinoma (LSCC) is a common cancer with high mortality and tumor mutation burden (TMB), and high TMB is associated with favorable survival. The expression, mutation, and survival data were obtained from The Cancer Genome Atlas database. The mutation and differentially expressed genes were analyzed using limma R package.

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Tao-Hong-Si-Wu-Tang (THSWT), a traditional Chinese herbal remedy, is commonly utilized for the treatment of female perimenopausal depression through regulating menstruation, but the mechanism remains unknown. In this study, ICR mice were randomly divided into six groups: low, medium, and high dose of THSWT (0.5, 1.

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  • Hepatogenous diabetes (HD) is a disorder related to glycogen metabolism, commonly seen in patients with cirrhosis due to chronic liver disease.* -
  • Patients with HD face a poor prognosis and are at increased risk for serious complications like gastrointestinal bleeding and hepatic encephalopathy, as their condition often worsens along with cirrhosis.* -
  • Despite the severity of HD, there is currently no established treatment strategy, prompting this paper to review recent advancements in treatment options to enhance patient outcomes.*
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Background: The severity of acute pancreatitis in pregnancy (APIP) is correlated with higher risks of maternal and fetal death.

Aim: To develop a nomogram that could predict moderately severe and severe acute pancreatitis in pregnancy (MSIP).

Methods: Patients with APIP admitted to West China Hospital between January 2012 and December 2018 were included in this study.

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  • The study compared the effectiveness of two internal fixation methods (unilateral vs. bilateral) for treating congenital scoliosis through hemivertebra resection using a posterior approach in 29 children aged 0.9 to 15 years.
  • Results showed that bilateral internal fixation had a shorter surgical time and less blood loss compared to unilateral fixation, with both methods leading to significant improvements in spinal curvature post-surgery.
  • While bilateral fixation showed a better initial correction rate for scoliosis angles, both methods had similar outcomes at the final follow-up, suggesting that unilateral fixation can also be an effective treatment option.
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Background: Deep vein thrombosis (DVT) may cause pulmonary embolus, leading to late deaths. The systemic inflammatory and hypercoagulable state of moderate and severe acute pancreatitis (non-mild acute pancreatitis, NMAP) patients may contribute to the development of venous thromboembolism. Accurate prediction of DVT is conducive to clinical decisions.

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  • Microbiota profiles in saliva differ significantly between pancreatic cancer patients and healthy individuals, suggesting potential for early detection of the disease.
  • A study involving 41 pancreatic cancer patients and 69 healthy controls identified specific bacterial taxa associated with higher and lower risks of pancreatic cancer.
  • Results indicated that certain bacteria in saliva could act as risk markers for pancreatic cancer, with correlations found between microbiome profiles and symptoms reported by patients.
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  • The study investigated the prevalence of depression among Chinese psychiatric medical staff, revealing a rate of 17.74%, which is higher than the general population but lower than other medical staff.
  • Cognitive performance, measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), showed significant deficits in those with depressive symptoms compared to those without.
  • Age and cognitive scores were found to be significant correlates of depression symptoms, indicating that interventions should focus on cognitive deficits and age-related factors in this population.
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To assess whether total pancreatectomy (TP) is as feasible, safe, and efficacious as pancreaticoduodenectomy (PD). Major databases, including PubMed, EMBASE, Science Citation Index Expanded, Scopus and the Cochrane Library, were searched for studies comparing TP and PD between January 1943 and June 2018. The meta-analysis only included studies that were conducted after 2000.

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The safety of minimally invasive distal pancreatectomy (MIDP) and open distal pancreatectomy (ODP) regarding oncological outcomes of pancreatic ductal adenocarcinoma (PDAC) remains inconclusive. Therefore, the aim of this study was to examine the oncological safety of MIDP and ODP for PDAC. Major databases including PubMed, Embase, Science Citation Index Expanded, and the Cochrane Library were searched for studies comparing outcomes in patients undergoing MIDP and ODP for PDAC from January 1994 to August 2018.

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Aim: To compare the safety of cholecystectomy in early laparoscopic cholecystectomy (ELC) and delayed laparoscopic cholecystectomy (DLC).

Methods: We systematically searched PubMed, EMBASE, and Cochrane Library for studies that were published from January 1992 to March 2017. We included studies on patients with mild biliary pancreatitis and that reported the timing of cholecystectomy and the number of complications, readmissions, and conversion to open cholecystectomy.

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Objectives: To investigate the effect of receptor for advanced glycation end products (RAGE) on cell proliferation and tumor growth in nude mice with pancreatic cancer.

Methods: PANC-1 cells were transfected with shRNA -1, -2, -3 to down-regulate the expression of RAGE. Cholecystokinin octopeptide-8 (CCK-8), real-time PCR and Western blot were performed to test the impact of shRNA on the expressions of mRNAs and proteins of RAGE, matrix metalloproteinase-2 (MMP-2), MMP-9, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and vascular endothelial growth factor (VEGF).

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A palladium-catalyzed three-component reaction between N-tosylhydrazones, 2-iodoanilines and atmospheric pressure CO was developed whereby a tandem carbene migration insertion/lactamization strategy afforded 4-aryl-2-quinolinones in moderate to good yields. Notably, a wide range of functional groups were tolerated in this procedure. This protocol features the simultaneous formation of four novel bonds; two C-C, one C=C and one C-N (amide), representing an efficient methodology for incorporation of CO into heterocycles.

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Aim: To identify the possible predictors of early complications after the initial intervention in acute necrotizing pancreatitis.

Methods: We collected the medical records of 334 patients with acute necrotizing pancreatitis who received initial intervention in our center. Complications associated with predictors were analyzed.

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Objective: By establishing C57-BABL/c mice allogeneic skin transplantation model, to analyze the immune system function with the administration of thymosin al (Tal) in mouse after skin transplantation; and to explore the mechanism of specific immune tolerance induced by Tal in vivo.

Methods: 80 C57 mice and 80 BABL/c mice were used as donor and acceptor respectively to establish C57-BABL/c mice allogeneic skin transplantation model and divided into four groups: Group A, control group (without any treatment, n=20); Group B, CsA treatment group (CsA 10 mg/kg, n=20); Group C, Tal treatment group (Tal 400 microg/kg, n=20) and Group D, combination therapy group (CsA 10 mg/kg & Talphal 400 microg/kg, n=20). In the three experimental group, the drug of each group were respectively administrated by intraperitoneal injection daily, for 21 d.

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Background: Cognitive deficits have been identified as an important core feature of schizophrenia. Single nucleotide polymorphisms in the transcription factor 4 (TCF4) gene have been reported to be involved in the susceptibility to schizophrenia and be significantly related to cognitive deficits of schizophrenia and controls. This study examines whether the TCF4 rs2958182 polymorphism influences cognitive functions in chronic schizophrenia and controls.

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This article aims to elucidate the classification of and optimal treatment for pancreatic pseudocysts. Various approaches, including endoscopic drainage, percutaneous drainage, and open surgery, have been employed for the management of pancreatic pseudocysts. However, no scientific classification of pancreatic pseudocysts has been devised, which could assist in the selection of optimal therapy.

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  • Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show clinical diversity, but there is limited data on Chinese patients, prompting a study analyzing 294 cases from 2007 to 2012.
  • The most common tumor site was the rectum, with abdominal pain being the primary symptom; the study found varying grades of tumors (G1-G3) and emphasized that endoscopy was the most effective detection method.
  • Results indicated that factors like tumor size, location, grade, and presence of metastasis negatively impacted patient outcomes, with a 5-year survival rate of 69.6%, while some findings were consistent with previous studies, others showcased notable differences.
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Objective: To analysis the effects of Talpha1 on the immune effector molecules in mouse immune system.

Methods: Sixty five BABL/c mice were divided into four groups: CsA group (n=20), Talpha1 group (n= 20), CsA+Talpha1 group (n=20) and control group (n=5). In the 3 experimental groups, 10 mg/kg CsA, 400 microg/ kg Talpha1, 10 mg/kg CsA+400 microg/kg Talpha1 were respectively administrated by intraperitoneal injection daily.

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Three patients with severe acute pancreatitis (SAP) developed into overt abdominal compartment syndrome (ACS) and confirmed or suspected infection of necrotic tissue. We successfully treated these patients by minimally invasive decompression with the assist of laparoscope after the failures of intensive care treatments. This technique we report here may be another safe and effective management for ACS in SAP.

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Objective: To analyze the clinical characteristic and management of patients with pancreatic injuries from the Wen-Chuan and Lu-Shan earthquakes.

Methods: We retrospectively reviewed 39,784 patients from the Wen-Chuan earthquake and 1489 from the Lu-Shan earthquake. The demographics, clinical data, treatment strategies, and outcomes of patients with pancreatic injuries were recorded and compared between survivors of the two earthquakes.

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Background: The early diagnosis of pancreas allograft dysfunction is crucial for the management and long-term survival of transplanted pancreases. We investigated whether intercellular adhesion molecular-1 (ICAM-1), Fas, and Fas ligand (FasL) can be used as novel biomarkers of acute pancreaticoduodenal allograft dysfunction in pigs.

Methods: Forty outbred landraces were randomly divided into three groups.

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