Publications by authors named "Wei-ling Liang"
Background: The endoscopic nasojejunal (NJ) placement plays a pivotal role in the nutritional support of critically ill patients. However, the conventional endoscopy-guided tube insertion method presents issues of excessive procedural duration. We have enhanced the traditional endoscopy-guided catheter placement method, enabling a faster and more convenient catheter insertion.
View Article and Find Full Text PDFCorrelation between High Incidence of Colorectal Neoplastic Polyps and High-risk Adenomas in Patients with Diabetes Mellitus: A Retrospective Study.
Endocr Metab Immune Disord Drug Targets
June 2024
Background: Early detection and resection of colorectal polyps by routine colonoscopy screening can be effective in reducing the risk of colorectal cancer (CRC).
Objective: This study aimed to determine the association between diabetes mellitus (DM) and different types of colorectal polyps in the Chinese population.
Methods: A retrospective analysis was performed on inpatients admitted to the Gastroenterology Department of our hospital from January to December 2019.
[Clinical efficacy of combined therapy in children with stage 4 neuroblastoma].
Zhongguo Dang Dai Er Ke Za Zhi
July 2022
Objectives: To study the early clinical efficacy of combined therapy of stage 4 neuroblastoma.
Methods: A retrospective analysis was performed on the medical data and follow-up data of 14 children with stage 4 neuroblastoma who were diagnosed in Hong Kong University-Shenzhen Hospital from January 2016 to June 2021.
Results: The median age of onset was 3 years and 7.
Phytochemical investigation of led to the isolation of two new halimane diterpenoids ( and ), a new -clerodane diterpenoid (), along with three known analogues (-). Their structures including absolute configurations were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and CD analysis. All isolates were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.
View Article and Find Full Text PDFBackground: To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway.
Methods: Thirty-seven paired colon cancer and its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed. Chip Analysis Methylation Pipeline (ChAMP) analysis was employed for differential methylated points (DMPs) and the differential methylation regions (DMRs) screening.
[Relationship between genotypes and clinical phenotypes in patients from 7 hemophilia A families].
Zhongguo Dang Dai Er Ke Za Zhi
September 2015
Article Synopsis
- * Researchers measured blood coagulation factors and performed genetic analyses, finding a significant mutation presence in exon 14 and noting a previously unreported mutation, p.His1202LeufsX16, in one patient.
- * The findings highlight exon 14 as a key mutation area and introduce a novel mutation variant, contributing to a better understanding of hemophilia A genetic factors.
[Molecular analysis of two pedigrees with inherited coagulation factor VII deficiency].
Zhonghua Er Ke Za Zhi
November 2012
Article Synopsis
- The study aims to explore gene mutations related to inherited coagulation factor VII (FVII) deficiency across two families, focusing on the connection between genetic changes (genotype) and observable traits (phenotype).
- Using techniques like PCR and direct sequencing, researchers identified specific mutations in the FVII gene, noting that proband 1 had a homozygous mutation leading to significant FVII deficiency, while proband 2 had a compound heterozygous condition with multiple mutations affecting his FVII levels.
- The findings suggest that mutations in the FVII gene's catalytic domain can disrupt FVII function and stability, leading to bleeding tendencies in individuals with homozygous or compound heterozygous
[Application of STR genetic marker system in the detection of hemophilia A carriers in Guangxi, China].
Zhongguo Dang Dai Er Ke Za Zhi
December 2012
Article Synopsis
- The study aims to create a quick and straightforward genetic diagnosis method to detect hemophilia A carriers using specific genetic markers in Guangxi, China.
- Researchers employed fluorescent PCR and capillary electrophoresis to analyze three genetic loci associated with the FVIII gene in individuals from 10 hemophilia A families.
- They found that genetic analysis at these loci reliably identified carriers, enabling faster and more accurate prenatal diagnosis of hemophilia A.