[Clinical characteristics of rheumatoid arthritis with cold pattern knee pain].

Objective: To investigate the clinical characteristic of rheumatoid arthritis associated with cold pattern knee joint pain.

Methods: The study enrolled 60 patients of RA with the complaint of knee pain, 30 cases with cold pattern and 30 cases without cold pattern. The clinical symptoms, DAS28 score, cold knee score were collected, and serum hypoxia inducible factor-1alpha (HIF-1alpha) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and thermal texture maps (TTM) of knee temperature were measured.