Publications by authors named "Wei-dong Wang"
Article Synopsis
- The study investigates the impact of vascular invasion (VI) on the prognosis of hepatocellular carcinoma (HCC) and seeks to identify specific biomarkers for patients with VI.
- Researchers analyzed transcriptome data from HCC tissues using functional enrichment analysis and combined it with clinical data to evaluate the correlation between differentially expressed genes (DEGs) and patient outcomes.
- A prognostic model was created using seven key genes, which successfully differentiated between low-risk and high-risk HCC patients, indicating that those in the high-risk category had worse prognoses; this model showed strong predictive ability over various time frames.
Article Synopsis
- - The rapid adsorption of biosurfactants, like surfactin, onto oil-water interfaces is crucial for effective emulsification, outperforming traditional chemically synthesized surfactants in reducing interfacial tension quickly.
- - In a study comparing surfactin (C-SFT) to sodium cetyl benzene sulfonate (8-SCBS), surfactin demonstrated superior stability in micro-droplet emulsions of hexadecane, significantly reducing coalescence and extending coalescence time at lower concentrations and short aging times.
- - Results showed that micro-droplets stabilized with surfactin remained intact and less prone to coalescence even after 600 ms, whereas those with 8-SCBS frequently combined into larger droplets
Background And Aims: The objective of this study was to investigate the effect of neutrophil-to-lymphocyte ratio (NLR) on the survival of cirrhotic patients with esophagogastric variceal bleeding (EGVB) treated with transjugular intrahepatic portosystemic shunt (TIPS).
Methods: A total of 293 patients treated with TIPS were included. The receiver operator characteristic curve (ROC) was used to calculate the optimal cut-off values of parameters such as NLR.
Background: Blackberry seeds, as a by-product of processing, have potential bioactive substances and activities. A response surface method was used to determine the optimal conditions of blackberry seed extracts (BSEs) with high 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity by ultrasound-assisted extraction (UAE). The composition and antioxidant capacity of BSEs were further analyzed.
View Article and Find Full Text PDFBackground: This study evaluated the prevalence and quantity of lymph nodes at particular stations of the mediastinum in patients with lung cancer. These data are important to radiologists, pathologists, and thoracic surgeons because they can serve as a benchmark when assessing the completeness of lymph node dissection. However, relevant data in the literature are scarce.
View Article and Find Full Text PDFOur previous study showed that levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) has potential diagnostic value for early-stage upper gastrointestinal cancers. This study aimed to assess whether serum IGFBP-1 is a potential diagnostic and prognostic biomarker for CRC patients. IGFBP-1 mRNA expression profile data of peripheral blood in colorectal cancer (CRC) patients were downloaded and analyzed from Gene Expression Omnibus database.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to evaluate the effectiveness and safety of combining hepatic arterial infusion chemotherapy (HAIC) with PD-(L)1 inhibitors and molecular targeted therapies (MTT) in patients with intermediate and advanced hepatocellular carcinoma (HCC) who cannot undergo TACE.
- - A total of 55 patients were analyzed, revealing a median overall survival of 15 months and a progression-free survival of 10 months, with notable response rates: 43.6% achieved an objective response and 61.8% had disease control.
- - The treatment was generally safe, with 58.2% of patients experiencing adverse events, but no treatment-related deaths occurred. Factors such as high NLR, ECOG status
Article Synopsis
- A significant percentage of colorectal cancer patients experience liver metastases, contributing to high mortality rates; studies suggest that the intestinal bacteria Fusobacterium nucleatum may play a role in this progression.
- A prospective, double-blind study will involve 300 patients to test if long-term use of the antibiotic metronidazole can reduce the occurrence of liver metastases after surgery.
- The study has received ethics approval and will share its findings through conferences and articles in peer-reviewed journals.
The urealytically active microorganism Sporosarcina luteola induces the precipitation of metals, which has attracted attention in biomineralization, bioremediation, and industrial waste recycling. Herein, we report a novel biosurfactant-producing strain of S. luteola ME44 isolated from Chinese Oilfield.
View Article and Find Full Text PDFBackground And Objectives: This study aimed to evaluate the efficacy and safety of transarterial chemoembolization (TACE) in patients with unresectable early or intermediate hepatocellular carcinoma (HCC) and Child-Pugh (CP)-B liver dysfunction.
Methods: This multicenter retrospective study enrolled patients with treatment-naïve HCC treated with TACE monotherapy between January 2012 and December 2020 at six Chinese hospitals. The primary outcome was overall survival (OS), and the secondary outcomes included the objective response rate (ORR) according to the modified RECIST and adverse events (AEs).
Background And Aims: To validate prognostic performance of the China liver cancer (CNLC) staging system as well as to compare these parameters with those of the Barcelona Clinic Liver Cancer (BCLC) staging system for Chinese hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE).
Methods: This multicenter retrospective study included 1,124 patients with HCC between January 2012 and December 2020 from six Chinese hospitals. Based on overall survival (OS), the prognostic performance outcomes for the CNLC and BCLC staging systems were compared by model discrimination [C statistic and Akaike information criterion (AIC)], monotonicity of the gradient (linear trend chi-square test), homogeneity (likelihood ratio chi-square test), and calibration (calibration plots).
The genus contains twelve species significant in the synthesis of cellulose-degrading enzymes and phenylalanine dehydrogenase, isolated mainly from marine sedimentary environments. Here, we report a new biosurfactant-producing strain, ME46, isolated from Daqing oil field in China. The biosurfactant extracted from Strain ME46 was determined as surfactin, one of the representative families of lipopeptide biosurfactants.
View Article and Find Full Text PDFBackground: Patients with proteinase 3-antineutrophil cytoplasmic antibody associated vasculitis (AAV) experience different manifestations at the initial onset and relapse. However, such cases of different initial and relapse manifestations have not been reported in myeloperoxidase (MPO)-AAV patients.
Case Summary: A 52-year-old woman was admitted to our hospital because of headache.
Purpose: Due to the poor and unpredictable prognosis of breast cancer (BC) patients with bone metastasis, it is necessary to find convenient and available prognostic predictors. This study aimed to recognize the clinical and prognostic factors related to clinical laboratory examination and to construct a prognostic nomogram for BC bone metastasis.
Methods: We retrospectively analyzed 32 candidate indicators from clinical features and laboratory examination data of 276 BC patients with bone metastasis.
The genus is active in degradation of hydrocarbons in thermophilic and facultative environments since it was first reported in 1920. Here, we report a new strain, ME63, isolated from an oilfield with the ability of producing the biosurfactant. The composition, chemical structure, and surface activity of the biosurfactant produced by ME63 were investigated by using a combination of the high-performance liquid chromatography, time-of-flight ion mass spectrometry, and surface tensiometer.
View Article and Find Full Text PDFBackground And Aim: Treatment strategy for hepatocellular carcinoma (HCC) and Vp4 [main trunk] portal vein tumor thrombosis (PVTT) remains limited due to posttreatment liver failure. We aimed to assess the efficacy of irradiation stent placement with 125 I plus transcatheter arterial chemoembolization (TACE) (ISP-TACE) compared to sorafenib plus TACE (Sora-TACE) in these patients.
Methods: In this multicenter randomized controlled trial, participants with HCC and Vp4 PVTT without extrahepatic metastases were enrolled from November 2018 to July 2021 at 16 medical centers.
Article Synopsis
- This study evaluates the combined effectiveness of transarterial chemoembolization (TACE) with PD-(L)1 inhibitors and molecular targeted treatments (MTT) compared to TACE alone in treating hepatocellular carcinoma (HCC).
- It involved 826 patients, with 376 receiving the combination treatment and 450 undergoing TACE monotherapy, and measured outcomes like progression-free survival (PFS) and overall survival (OS).
- Findings indicated that the combination treatment significantly improved PFS (9.5 months vs. 8.0 months) and OS (19.2 months vs. 15.7 months) while maintaining a manageable safety profile, especially in patients with advanced HCC.
Article Synopsis
- The study compared continuous hand-sewn esophagojejunostomy using barbed suture with mechanical anastomosis during total laparoscopic gastrectomy for treating esophagogastric junction cancer.
- Data from 60 patients (30 in each group) showed that the hand-sewn technique had a significantly shorter anastomosis time and lower operation costs while achieving a longer tumor margin.
- The results suggest that the hand-sewn anastomosis is a practical, safe, and cost-effective method, serving as an effective supplement to mechanical anastomosis without increasing the risk of postoperative complications.
Background: This study aimed to evaluate whether a large paraumbilical vein (L-PUV) was independently associated with the occurrence of overt hepatic encephalopathy (OHE) after the implantation of a transjugular intrahepatic portosystemic shunt (TIPS). Methods: This bi-center retrospective study included patients with cirrhotic variceal bleeding treated with a TIPS between December 2015 and June 2021. An L-PUV was defined in line with the following criteria: cross-sectional areas > 83 square millimeters, diameter ≥ 8 mm, or greater than half of the diameter of the main portal vein.
View Article and Find Full Text PDFThe avian immunosuppressive and neoplastic diseases caused by Marek's disease virus (MDV), avian leucosis virus (ALV), and reticuloendotheliosis virus (REV) are seriously harmful to the global poultry industry. In recent years, particularly in 2020-2022, outbreaks of such diseases in chicken flocks frequently occurred in China. Herein, we collected live diseased birds from 30 poultry farms, out of 42 farms with tumour-bearing chicken flocks distributed in central China, to investigate the current epidemiology and co-infections of these viruses.
View Article and Find Full Text PDFArticle Synopsis
- Proximal gastrectomy is becoming popular because it helps preserve stomach function, but it can lead to complications that impact quality of life, prompting the need for better surgical techniques.
- A new study will compare the left-open single-flap technique with the double-flap technique in a multicenter randomized trial involving 250 patients to see which method reduces surgical difficulties and complications.
- The goal is to provide evidence for improving surgical reconstruction methods after proximal gastrectomy, contributing to better clinical practices and guidelines.
Objectives: To analyze the case, scene and forensic pathological characteristics of sudden unexpected death in epilepsy (SUDEP), to provide a practical basis for forensic identification.
Methods: A total of 9 autopsy cases of SUDEP were collected. The basic information of the cases, the scene characteristics, the forensic pathological changes, the common drugs and antiepileptic drug test results, and pericardial fluid biochemical test results were analyzed.
Background: α-1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study, we explored the association of serum FUT8 activity with renal tubulointerstitial injury in IgAN patients.
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- - The study investigates deep vein thrombosis (DVT) in 1,750 patients with gastric and colorectal cancers, identifying how often it occurs and the associated risk factors, particularly before surgery.
- - Out of the patients reviewed, 73 were found to have DVT, resulting in a prevalence rate of 4.17%, with significant risk factors including being female, stage IV cancer, and higher ASA class.
- - The findings suggest that preoperative venous ultrasonography can effectively detect DVT, helping to prevent postoperative complications like pulmonary thromboembolism (PTE), making it a vital tool in surgical planning for these cancer patients.