Assessment of the antimicrobial and immunomodulatory activity of QS-CATH, a promising therapeutic agent isolated from the Chinese spiny frogs (Quasipaa spinosa).

Cathelicidins are important antimicrobial peptides in various vertebrate species where they are crucial parts of the innate immune system. The current understanding of amphibian cathelicidins is limited, particularly with regard to their immunomodulatory effects. To address this knowledge gap, we produced the cDNA sequence of the cathelicidin gene from a skin transcriptome of the Chinese spiny frog Quasipaa spinosa.

Effects of Early-Stage Blood Pressure Variability on the Functional Outcome in Acute Ischemic Stroke Patients With Symptomatic Intracranial Artery Stenosis or Occlusion Receiving Intravenous Thrombolysis.

Background: Studies exploring the relationship between blood pressure (BP) fluctuations and outcome in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) are limited. We aimed to investigate the influence of blood pressure variability (BPV) during the first 24 h after IVT on early neurological deterioration (END) and 3-month outcome after IVT in terms of different stroke subtypes.

Methods: Clinical data from consecutive AIS patients who received IVT were retrospectively analyzed.

The complete mitochondrial genome of (Anura: Ranidae) and its phylogenetic analysis.

We reported the complete mitochondrial genome (mitogenome) of broad-folded frog (). This mitogenome is 17,007 bp in size and consists of 13 protein-coding genes, 22 transfer RNAs, two ribosomal RNAs, and one non-coding sequence (D-loop). The total composition was 58.

Characterization of the complete mitochondrial genome of the Chong'an Moustache Toad, (Pope, 1947) with a phylogenetic analysis of Megophryidae.

The Chong'an Mustache Toad, (Pope, 1947) is a Chinese endemic species, inhabiting the mountain streams with rich vegetation in southeastern China. The first complete mitochondrial genome (mitogenome) of was assembled using the data of whole-genome sequencing. The size of the complete mitogenome for was 17,190 bp, which included 13 , 23 with two concatenated genes, 2 , a non-coding region, and a .

Next-generation sequencing yields the complete mitochondrial genome of (Anura: Microhylidae).

The complete mitochondrial genome (mtDNA) of (Anura: Microhylidae) was sequenced and annotated. The length of mtDNA sequences of was 16,721 bp, and encoded 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes, and a control region. The overall nucleotide composition of this genome was 29.

The advertisement call of the moustache toad Leptobrachium liui Pope, 1947 (Anura: Megophryidae) from eastern China.

The Leptobrachium genus is currently composed of 36 species distributed in Southern China, India, islands of the Sunda Shelf, and the Philippines (Frost 2019). In China, 11 species of the genus Leptobrachium are currently known (AmphibiaChina 2019), of which, the following nine are Chinese endemic: L. bompu (Sondhi Ohler 2011), L.

Adult-onset mitochondrial encephalopathy in association with the T10158C mutation exhibits unique characteristics: A case report.

Background: Mitochondrial diseases are a heterogenous group of multisystemic disorders caused by genetic mutations affecting mitochondrial oxidation function. Brain involvement is commonly found in most cases but rarely as the unique clinical manifestation. Since the knowledge of its clinical manifestation combined with genetic testing is important for preventing misdiagnosis and delay in treatment, we report here how we diagnosed and managed a very unusual case of mitochondrial encephalopathy.

[Value of lower-limb short latency somatosensory evoked potentials in predicting early death in patients with massive cerebral infarction].

Objective: To explore the value of lower-limb short latency somatosensory evoked potentials (SLSEP) in predicting early death in patients with massive cerebral infarction.

Methods: Forty-eight patients of massive cerebral infarction were admitted in the Neurological Intensive Care Unit (NICU) between March 2008 and March 2009, and Glasgow-Pittsburgh coma scale (GPCS) and SLSEP were recorded and graded within 24 h after admission. The patients were divided into survival and death groups (including brain death) according to their short-term prognosis.