Impact of hepatitis C virus genotype 3 on liver disease progression in a Chinese national cohort.

Background: Hepatitis C virus (HCV) genotype 3, particularly subtype 3b, is increasing in prevalence and distribution in China. This study evaluated the prevalence, regional distribution, clinical characteristics, host factors, treatment outcomes, and disease progression of patients with HCV genotype 3 in China.

Methods: A 5-year follow-up was preceded by a cross-sectional study.

[Pathological grading analysis of liver biopsies in chronic hepatitis B virus carriers of different age ranges].

Objective: To study the best time of taking liver biopsy for chronic HBV carriers of age ranges and then guiding antiretroviral treatment.

Method: The liver biopsy pathologic results of 292 cases of chronic HBV carriers were collected from the First Affiliated Hospital of Kunming Medical College. The patients were divided into three groups according to ages.

[Effects of exogenous NO on ascorbate-glutathione cycle in loquat leaves under low temperature stress].

Three-year-old 'Zaozhong No. 6' loquat (Eriobotrya japonica Lindl.) seedlings were foliar-sprayed with 0.

Detection of HBV, PCNA and GST-pi in hepatocellular carcinoma and chronic liver diseases.

Aim: To investigate the change of HBV DNA, PCNA and GST-pi in chronic liver disease and hepatocellular carcinoma (HCC).

Methods: Hepatitis B surface antigen (HBsAg), proliferating cell nuclear antigen (PCNA) and glutathione S-transferases (GST-pi) were detected by immunohistochemical staining and HBV DNA was detected by in situ hybridization (ISH) in formalin-fixed and paraffin-embedded sections with a total of 111 specimens of chronic hepatitis, liver cirrhosis, paratumorous tissue, HCC and normal liver tissue.

Results: The positive rates of HBsAg and HBVDNA were 62.

[Expression of GST-pi and HBV infection in hepatocellular carcinoma].

Background & Objective: The expression of glutathione S-transferases(GST-pi) might abnormally increase in many carcinogenesis, and the alteration of GST-pi preceded than that alteration of cell morphology. This study was designed to investigate the expression of glutathione S-transferases (GST-pi) and its relationship with hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC).

Methods: Hepatitis B surface antigen (HBsAg), Hepatitis B core antigen (HBcAg), and GST-pi were detected by immunohistochemical staining and HBV DNA was detected by in situ hybridization (ISH) in total 86 samples of chronic hepatitis, liver cirrhosis, paratumor cirrhosis, HCC, and normal liver tissue.