Publications by authors named "Wei-Zhe Pan"
Objective: Arsenic (As) and fluoride (F) are two of the most common elements contaminating groundwater resources. A growing number of studies have found that As and F can cause neurotoxicity in infants and children, leading to cognitive, learning, and memory impairments. However, early biomarkers of learning and memory impairment induced by As and/or F remain unclear.
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- Vinyl chloride (VC) is an environmental pollutant that worsens liver fat accumulation (hepatic steatosis) when combined with a high-fat diet, particularly in recent dietary shifts among Chinese populations.
- Research shows that exposure to VC exacerbates oxidative stress and endoplasmic reticulum stress in the liver, leading to increased levels of proteins associated with fat production.
- Antioxidants and inhibitors targeting stress responses can help reduce liver fat buildup caused by VC and its metabolite, indicating potential pathways for managing liver disease risks linked to dietary changes.
Hypertension is a common chronic disease in middle-aged and elderly people and is an important risk factor for many cardiovascular diseases. Its pathogenesis remains unclear. Epidemiological studies have found that the loss of telomere length in peripheral blood cells can increase the risk of coronary heart disease, myocardial infarction, and other diseases.
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