Antitumor effects of new glycoconjugated Pt agents dual-targeting GLUT1 and Pgp proteins.

A novel and highly efficient dual-targeting Pt system was designed to improve the drug delivery capacity and selectivity in cancer treatment. The dual-targeting monofunctional Pt complexes (1-8) having glycosylated pendants as tridentated ligand were achieved by introducing glycosylation modification in the thioaminocarbazone compounds with potential lysosomal targeting ability. The structures and stability of 1-8 were further established by various techniques.

High-resolution Sonographic Measurements of Lower Extremity Bursae in Chinese Healthy Young Men.

Background: Lower extremity bursae are very vulnerable to injury during strenuous physical exercises. Understanding the imaging characteristics of normal bursae is essential for early diagnosis of morphological abnormalities. Therefore, we evaluated the normal range of lower extremity bursae in healthy young men using high-resolution ultrasound (HR-US) imaging.

Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population.

Polymorphism rs7214723 was reported to be associated with lung cancer risk in UK Caucasians and caused the E375G substitution of CAMKK1 which plays important role in the calcium/calmodulin-dependent kinase cascade. To analyze rs7214723 in CAMKK1 and lung cancer risk in a Chinese population, SNPscan(TM) was used to genotype polymorphism rs7214723 in 961 lung cancer cases and 999 control subjects. The frequencies of the TT, TC, and CC genotypes of CAMKK1 rs7214723 were 43.

[Extraction of Cd by ramie from soils as affected by applications of chelators and peat].

Pot experiments were performed to study the effectiveness of chelators (EDTA, citric acid) and peat in enhancing phyremediation of heavy metal Cd by ramie. The results showed that peat increased the ramie's biomass by improving soil's physical and chemical properties, and the relative yields of peat alone, chelators(EDTA, citric acid) combined with peat were 1.23, 1.